Diagnostic Value of Common Inflammatory Markers on Fever of Unknown Origin

Liu, Cuiping; Liu, Junping; Yi, Kang; Mao, Chongshan; Shang, Jia

doi:10.7883/yoken.jjid.2015.470

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…In another pediatric study, there was no difference in the frequencies of CTD in patients with fever 14–30 days and in patients with fever over 30 days1). In one study of adults, there were no significant relationship between fever duration and the etiology of FUO26). In another study of adults, Yu et al27) reported that the infection group had a relatively shorter average duration of fever than the other groups.…”

Section: Discussionmentioning

confidence: 93%

Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Kim

Kang

et al. 2017

Korean J Pediatr

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PurposeFever is one of the most common symptoms in children. In previous studies, infectious disease was the most common cause of pediatric fever of unknown origin (FUO). The aim of this study is to investigate the etiology, clinical characteristics and prognosis of pediatric FUO in 21 century with more diagnostics available and to analyze the factors for certain disease categories.MethodsAmong the children under 18 years old who were hospitalized at Samsung Medical Center from January 2000 to December 2014, the patients who met the criteria including fever of ≥38.0℃ for longer than ≥14 days and failure to reach a diagnosis after one week of investigations were included.ResultsTotal 100 patients were identified. Confirmed diagnosis was achieved in 57 patients (57%). Among them, infectious diseases (n=19, 19%) were most common, followed by connective tissue diseases (n=15, 15%), necrotizing lymphadenitis (n=8, 8%), and malignancies (n=7, 7%). Children with fever duration over 28 days had a trend for higher frequency of connective tissue diseases (28.3%) except undiagnosed etiology. The symptoms such as arthritis, lymph node enlargement and only fever without other symptoms were significantly related with connective tissue diseases, necrotizing lymphadenitis and undiagnosed respectively (P<0.001). Ninety-two patients have become afebrile at discharge and 1 patient died (1%).ConclusionAlmost half of our patients were left without diagnosis. Although it has been known that infectious disease was most common cause of pediatric FUO in the past, undiagnosed portion of FUO have now increased due to development of diagnostic techniques for infectious diseases.

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Section: Discussionmentioning

confidence: 93%

Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Kim

Kang

et al. 2017

Korean J Pediatr

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“…This model was sustained by the fact that, in group I, the serum iron was lower than in group 0, the same as for the hemoglobin and ferritin values. In addition, the normal clinical examination and level of leucocytes, along with low ferritin in the anemic group and not higher than expected in the intervention group, were markers of infection absence [25].…”

Section: Discussionmentioning

confidence: 66%

The Ideal Time for Iron Administration in Anemia Secondary to Blood Loss—An Experimental Animal Model

Ţigliş

Peride

Petcu

et al. 2021

Life

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Background: Anemia and iron deficiency are two of the main public health problems worldwide, associated with negative outcomes in surgical patients. This experimental study aimed to create a model of acute iron deficiency with anemia through blood loss and extensive surgery. Afterwards, intravenous iron was administered to correct the iron deficiency and to improve the hematological parameters in distinct moments regarding the surgical time. To assess the optimum time for therapeutic intervention, experimental subjects were compared, performing clinical, paraclinical, and histological examinations, as well. Methods: Male rats (n = 35), aged 11–13 months, were randomly designated into six groups. Anemia and iron deficiency were obtained through a 15% blood volume loss, followed by major surgical intervention (femur fracture and osteosynthesis using Kirschner wire). Therapeutic intervention was obtained with an intravenous ferric carboxymaltose infusion, as follows: group II: intraoperative (n = 7), group III: 48 h after surgery (n = 7), group IV: 48 h before surgery (n = 5), and group V: seven days before surgery (n = 6). Group I (n = 5) was left anemic, while group 0 (n = 5) was nonanemic without therapeutic intervention. Results and Discussion: In group I, serum iron lower than in group 0 (27.04 ± 6.92 μg/dL versus 60.5 ± 2.34 μg/dL), as well as hemoglobin (10.4 ± 0.54 g/dL versus 14.32 ± 2.01 g/dL) and ferritin values (22.52 ± 0.53 ng/mL versus 29.86 ± 3.97 ng/mL), validated the experimental model. Regarding wound healing after surgical trauma, we observed that neovascularization was more significant in group III, followed by group V, with fewer neutrophils, a well-represented and rich in lymphomonocytes inflammatory infiltrate associated with the biggest collagen fiber dimensions. The periosteal reaction and callus area presented thicker trabeculae in groups II and III compared to the anemic group. Conclusions: This original experimental study assessed the effect of perioperative intravenous iron administration at a specific time by comparing the weight, hematological, and iron status-defining parameters, as well as histological characteristics of the included subjects. The present findings highlight that correcting the iron deficiency in emergency settings through intravenous iron administration intraoperatively or 48 h postoperatively could determine the improved bioumoral parameters, as well as a better evolution of the postoperative wound and bone healing compared to the anemic group or subjects that received therapeutic intervention 48 h before surgery.

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“…They added that clinical and epidemiological criteria showed that the infectious diseases were the commonest (63.4%), followed by autoimmune diseases (30.3%) and malignancies (0.9%), while the undiagnosed (3.2%). But, Liu et al (2016) in Japan reported that the FUO infectious diseases were 33.9% cases, followed by the collagen diseases (25.1%), lastly neoplasms (21.1%), and that adultmost common collagen cause of FUO, but unidentified causes were 19.8%.…”

Section: Discussionmentioning

confidence: 98%

Epidemiology of Fever of Unknown Origin (Fuo) at Imbaba Fever Hospital, Giza Governorate, Egypt

AlBalakosy

HUSSEIN

KHALIL³

et al. 2022

Journal of the Egyptian Society of Parasitology

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Fever of unknown origin (FUO) is caused by various diseases, and infections were the most frequent causes of FUO. The progress of the diagnostic techniques may have changed the breakdown of diseases causing FUO. This prospective study aimed to explore the clinical spectrum of fevers of undetermined origin (FUO) among adult patients treated at the Imbaba Fever Hospital from June 2018 to May 2019.All Egyptian patients who met the FUO criteria and were hospitalized during this period were followed up until they were diagnosed. They were 350 of whom186 females (53.1%) and 164 males (46.9%), with ages ranged from 18 to 82 years (32.77±14.4). The commonest FUO cause was infections (72%), followed by autoimmune diseases (20%), malignancies accounted (2%) of the total with the diagnosis unknown in 4.6%. Brucellosis and pneumonia were considered major causes of infections.

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Diagnostic Value of Common Inflammatory Markers on Fever of Unknown Origin

Cited by 9 publications

References 33 publications

Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center

The Ideal Time for Iron Administration in Anemia Secondary to Blood Loss—An Experimental Animal Model

Epidemiology of Fever of Unknown Origin (Fuo) at Imbaba Fever Hospital, Giza Governorate, Egypt

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