Diagnostic Value of CT Density in Patients With Diffusely Increased FDG Uptake in the Thyroid Gland on PET/CT Images

Han, You Mie; Kim, Young Chul; Park, Eun Kyung; Choe, Jae Gol

doi:10.2214/ajr.09.3319

Cited by 20 publications

(22 citation statements)

References 21 publications

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“…Because colloid volume is about 3 times greater than the epithelial cell volume, 18 the high electron density of the iodine colloid leads the high attenuation of the thyroid on MDCT. [19][20][21] Our results are confirmed in a report by Han et al, 22 who studied the appearance of the thyroid gland using PET/CT. They found that thyroid density is proportional to colloid volume and inversely proportional to the cellular component of the thyroid and FDG avidity.…”

Section: Discussionsupporting

confidence: 88%

Distinguishing Recurrent Thyroid Cancer from Residual Nonmalignant Thyroid Tissue Using Multiphasic Multidetector CT

Debnam¹,

Guha-Thakurta²,

Sun³

et al. 2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: During thyroidectomy incomplete resection of the thyroid gland may occur. This complicates the imaging surveillance of these patients as residual thyroid needs to be distinguished from local recurrence. Therefore, the purpose of this study was to determine if multiphasic multi-detector computed tomography (4D-MDCT) can differentiate residual nonmalignant thyroid tissue and recurrent thyroid carcinoma after thyroidectomy. MATERIALS AND METHODS: In this retrospective study, Hounsfield unit values on multiphasic multidetector CT in precontrast, arterial (25 seconds), venous (55 seconds), and delayed (85 seconds) phases were compared in 29 lesions of recurrent thyroid cancer, 29 with normal thyroid, and 29 with diseased thyroid (thyroiditis/multinodular thyroid). The comparison of Hounsfield unit values among lesion types by phase was performed using ANOVA. The performance of Hounsfield unit values to predict recurrence was evaluated by logistic regression and receiver operating characteristic analysis. RESULTS: All 3 tissue types had near-parallel enhancement characteristics, with a wash-in-washout pattern. Statistically different Hounsfield unit density was noted between the recurrence (lowest Hounsfield unit), diseased (intermediate Hounsfield unit), and normal (highest Hounsfield unit) thyroid groups throughout all 4 phases (P , .001 for each group and in each phase). Dichotomized recurrenceversus-diseased/normal thyroid tissue with univariate logistic regression analysis demonstrated that the area under the receiver operating characteristic curve for differentiating benign from malignant thyroid for the various phases of enhancement was greatest in the precontrast phase at 0.983 (95% CI, 0.954-1), with a cutoff value of #62 (sensitivity/specificity, 0.966/0.983) followed by the arterial phase. CONCLUSIONS: Recurrent thyroid carcinoma can be distinguished from residual nonmalignant thyroid tissue using multiphasic multidetector CT with high accuracy. The maximum information for discrimination is in the precontrast images, then the arterial phase. An optimal clinical protocol could be built from any number of phases but should include a precontrast phase.

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Section: Discussionsupporting

confidence: 88%

Distinguishing Recurrent Thyroid Cancer from Residual Nonmalignant Thyroid Tissue Using Multiphasic Multidetector CT

Debnam¹,

Guha-Thakurta²,

Sun³

et al. 2020

AJNR Am J Neuroradiol

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“…This may be explained by the fact that the measurement of thyroid tissue by the CT value can only partly reflect the iodine content of the thyroid, and it may also be affected by the density of thyroid tissue. Studies have shown that different thyroid disease tissues have different CT values, and in most cases, the CT values of thyroid disease tissues are lower than those of normal thyroid tissues [15,16]. Therefore, compared with the CT value, the measurement of the iodine concentration and iodine content has more advantages in determining the pathological changes of thyroid tissue and iodine ion content in the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients: a cross-sectional study in China

Li¹,

Zhai²,

Li³

et al. 2020

BMC Med Imaging

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Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: Forty-three patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion: The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

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“…This may be explained by the fact that the measurement of thyroid tissue by the CT value can only partly reflect the iodine content of the 8 thyroid, and it may also be affected by the density of thyroid tissue. Studies have shown that different thyroid disease tissues have different CT values, and in most cases, the CT values of thyroid disease tissues are lower than those of normal thyroid tissues [15,16] . Therefore, compared with the CT value, the measurement of the iodine concentration and iodine content has more advantages in determining the pathological changes of thyroid tissue and iodine ion content in the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

Zhai

Liu

et al. 2019

Preprint

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Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion: The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

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Diagnostic Value of CT Density in Patients With Diffusely Increased FDG Uptake in the Thyroid Gland on PET/CT Images

Abstract: CT density is closely related to FDG uptake, and low CT density coupled with high FDG uptake suggests a change in thyroid tissue composition and is probably helpful for assessing the disease process and thyroid function of patients whose thyroid show diffuse FDG uptake on FDG PET/CT.

Cited by 20 publications

References 21 publications

Distinguishing Recurrent Thyroid Cancer from Residual Nonmalignant Thyroid Tissue Using Multiphasic Multidetector CT

Distinguishing Recurrent Thyroid Cancer from Residual Nonmalignant Thyroid Tissue Using Multiphasic Multidetector CT

Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients: a cross-sectional study in China

Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

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