Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant tumor

Dong, Li; Li, Kuo; Peng, Taisong

doi:10.1097/md.0000000000024251

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…On the other hand, the productive manpower is lost. 16 The present study found sensitivity of DW-MRI to be 92.68% and specificity of 73 17 However, it is evident the diagnostic potential of DW-MRI is better than simple MRI. 18 The false positive cases of DW-MRI were found to be teratoma or adenomyosis on histopathology.…”

Section: Discussionmentioning

confidence: 44%

Diagnostic accuracy of diffusion weighted imaging on MRI in suspected cases of ovarian cancer, keeping histopathology as gold standard.

Maryam Latif,

Salahuddin Balooch,

Zeeshan Ali

et al. 2024

TPMJ

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Objective: To assess the diagnostic accuracy of diffusion weighted imaging on MRI in patients of ovarian cancer with histopathology considered as gold standard. Study Design: Cross-sectional study. Setting: Department of Radiology, Tertiary Care Hospital Kharian. Period: February 2022 to August 2022. Material & Methods: Non-probability, consecutive sampling was performed from 60 patients. After receiving informed consents, the suspected female patients with age 15 to 65 years went under MRI. The results were compared with histopathological findings and diagnostic potential of MRI was calculated by 2x2 table. The findings of both the modalities were compared by correlation analysis with p<0.05 considered as significant. Results: The sensitivity and specificity of MRI were estimated to be 92.68% and 73.68%. The positive predictive value and negative predictive value were estimated to be 88.37% and 82.35%. The diagnostic accuracy was found to be 86.66%. The findings of MRI and histopathology were significantly (p<0.05) correlated with a value of 0.685. Conclusion: The use of MRI is highly recommended in diagnosis of ovarian cancer.

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Section: Discussionmentioning

confidence: 44%

Diagnostic accuracy of diffusion weighted imaging on MRI in suspected cases of ovarian cancer, keeping histopathology as gold standard.

Maryam Latif,

Salahuddin Balooch,

Zeeshan Ali

et al. 2024

TPMJ

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“…In a recent meta-analysis, 10 studies with a total of 353 patients were included to elucidate the diagnostic accuracy of DWI for peritoneal carcinomatosis [ 19 ]. The pooled sensitivity of DWI for peritoneal tumours was 89% (95%CI: 83–93%), and the pooled specificity was 86% (95% CI: 79–91%) [ 19 ]. Notably, the study pooled results for all available primary tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the patient cohort is relatively small. However, similar studies investigating the diagnostic abilities of DWI had comparable sample sizes [ 19 ]. Second, the reading was performed with the knowledge that peritoneal carcinomatosis was present, which could have an influence on the results.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging of Peritoneal Carcinomatosis: Evaluation of High b-Value Computed Diffusion-Weighted Imaging

et al. 2022

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Over the last few years, diffusion-weighted imaging (DWI) has become increasingly relevant in the diagnostic assessment of peritoneal carcinomatosis. The aim of this study was to investigate the benefits of high-b DWI (c-DWI) compared to standard DWI in patients with peritoneal carcinomatosis. A cohort of 40 patients with peritoneal carcinomatosis were included in this retrospective study. DWI was performed with b-values of 50, 400, and 800 or 1000 s/mm² on a 1.5-T magnetic resonance imaging (MRI) scanner. C-DWI was calculated using a mono-exponential model with high b-values of 1000, 2000, 3000, 4000, and 5000 s/mm². All c-DWI images with high b-values were compared in terms of volume, detectability of peritoneal lesions, and image quality with the DWI sequence acquired with a b-value of 800 or 1000 s/mm² by two readers. In the group with a b-value of 800 s/mm², there was no statistically significant difference in terms of lesion volume. In the second group with a b-value of 1000 s/mm², peritoneal carcinomatosis lesions were statistically significantly larger than in the c-DWI with a- high b-value of 2000 s/mm² (median 7 cm³, range 1–26 cm³ vs. median 6 cm³, range 1–83 cm³, p < 0.05). In both groups, there was a marked decrease in the detectability of peritoneal lesions starting at b = 2000 s/mm². In addition, image quality decreased noticeably from c-DWI at b = 3000 s/mm². In both groups, all images with high b-values at b = 4000 s/mm² and 5000 s/mm² were not diagnostically valuable due to poor image quality. The c-DWI technique offers good diagnostic performance without additional scanning time. High c-DWI b-values up to b = 1000 s/mm² provide comparable detectability of peritoneal carcinomatosis compared to standard DWI. Higher b-values over 1500 s/mm² result in lower image quality, which might lead to misdiagnosis.

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“…Several studies have proven that adding DWI to conventional MR increases the detection of peritoneal deposits [ 10 , 12 , 13 ], even of small size [ 14 ]. Tumoral deposits, due to their high cellular content, restrict the diffusion of water and are displayed as high signal intensity lesions [ 15 ], which increases their conspicuity.…”

Section: Diagnostic Modalitiesmentioning

confidence: 99%

Unravelling Peritoneal Carcinomatosis Using Cross-Sectional Imaging Modalities

Veron Sanchez,

Bennouna,

Coquelet

et al. 2023

Diagnostics

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Peritoneal carcinomatosis (PC) refers to malignant epithelial cells that spread to the peritoneum, principally from abdominal malignancies. Until recently, PC prognosis has been considered ill-fated, with palliative therapies serving as the only treatment option. New locoregional treatments are changing the outcome of PC, and imaging modalities have a critical role in early diagnosis and disease staging, determining treatment decision making strategies. The aim of this review is to provide a practical approach for detecting and characterizing peritoneal deposits in cross-sectional imaging modalities, taking into account their appearances, including the secondary complications, the anatomical characteristics of the peritoneal cavity, together with the differential diagnosis with other benign and malignant peritoneal conditions. Among the cross-sectional imaging modalities, computed tomography (CT) is widely available and fast; however, magnetic resonance (MR) performs better in terms of sensitivity (92% vs. 68%), due to its higher contrast resolution. The appearance of peritoneal deposits on CT and MR mainly depends on the primary tumour histology; in case of unknown primary tumour (3–5% of cases), their behaviour at imaging may provide insights into the tumour origin. The timepoint of tumour evolution, previous or ongoing treatments, and the peritoneal spaces in which they occur also play an important role in determining the appearance of peritoneal deposits. Thus, knowledge of peritoneal anatomy and fluid circulation is essential in the detection and characterisation of peritoneal deposits. Several benign and malignant conditions show similar imaging features that overlap those of PC, making differential diagnosis challenging. Knowledge of peritoneal anatomy and primary tumour histology is crucial, but one must also consider clinical history, laboratory findings, and previous imaging examinations to achieve a correct diagnosis. In conclusion, to correctly diagnose PC in cross-sectional imaging modalities, knowledge of peritoneal anatomy and peritoneal fluid flow characteristics are mandatory. Peritoneal deposit features reflect the primary tumour characteristics, and this specificity may be helpful in its identification when it is unknown. Moreover, several benign and malignant peritoneal conditions may mimic PC, which need to be considered even in oncologic patients.

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Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant tumor

Cited by 11 publications

References 29 publications

Diagnostic accuracy of diffusion weighted imaging on MRI in suspected cases of ovarian cancer, keeping histopathology as gold standard.

Diagnostic accuracy of diffusion weighted imaging on MRI in suspected cases of ovarian cancer, keeping histopathology as gold standard.

Magnetic Resonance Imaging of Peritoneal Carcinomatosis: Evaluation of High b-Value Computed Diffusion-Weighted Imaging

Unravelling Peritoneal Carcinomatosis Using Cross-Sectional Imaging Modalities

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