Diagnostic Value of Diffusion-Weighted Magnetic Resonance Imaging in Pediatric Cerebral Diseases

Oksuzler, Yasemin Fatma; Çakmakçı, Handan; Kurul, Semra Hız; Öksüzler, Mahmut; Dırık, Eray

doi:10.1016/j.pediatrneurol.2004.12.007

Cited by 17 publications

(22 citation statements)

References 39 publications

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“…DW-MRI is increasingly being used in other situations [24,25]. The main utility of DW-MRI appears to be increased diagnostic accuracy when used in conjunction with standard MRI, due to independent lesion characterization and apparent diffusion coefficient calculations [24,25].…”

Section: Discussionmentioning

confidence: 99%

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema

Pakzad-Vaezi¹,

Cochrane²,

Sargent

et al. 2009

Pediatr Neurosurg

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We present a case report of a 21-month-old female patient to highlight magnetic resonance (MR) imaging findings associated with papilledema in a pediatric patient with an intracranial tumor. The MR findings included optic disc elevation, dilated perioptic subarachnoid spaces, optic nerve tortuosity and restricted diffusion in the optic nerve heads, all of which resolved upon resolution of raised intracranial pressure (ICP) and papilledema. The case demonstrates that both conventional and diffusion-weighted MR imaging findings can detect the presence, and follow posttreatment resolution, of increased ICP and papilledema in a pediatric tumor patient. The postoperative resolution of optic disc elevation clearly indicates the intracranial tumor etiology.

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Section: Discussionmentioning

confidence: 99%

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema

Pakzad-Vaezi¹,

Cochrane²,

Sargent

et al. 2009

Pediatr Neurosurg

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“…This sequence has usually been used to evaluate acute ischemia, differentiate cytotoxic and vasogenic edema and assess myelination in pediatric brain 4 . According to previous studies brain water diffusion reflects the maturation and structural integrity of white and grey matter, and after two years of age ADC values are nearly identical to adult values 4 .…”

Section: Discussionmentioning

confidence: 99%

Apparent Diffusion Coefficient is Increased in Children with Tuberous Sclerosis Complex Personal Experience and Review of the Literature

Jurkiewicz

Jóźwiak

Bekiesińska‐Figatowska³

et al. 2007

Neuroradiol J

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Diffusion-weighted imaging (DWI) provides information on tissue integrity and shows increased sensivity in detecting brain white matter disease compared to traditional T2-weighted MRI. We compared apparent diffusion coefficient (ADC) values in brain lesions and normal appearing white matter (NAWM) in patients with tuberous sclerosis complex (TSC) to normal brain tissue in the control group. MRI and DWI were performed in 14 patients with TSC (age range 7-16 years) and in 18 age-matched normal control subjects. ADC values measured from 44 supratentorial cortical tubers, 37 white matter lesions, 80 NAWM were compared to those in control subjects. Statistical analysis was performed using Kruskal-Wallis and Mann-Whitney U tests. The highest ADCs were measured in cortical tubers (mean ADC, 1.24×10-3 mm(2)/s), followed in descending order by WM lesions (mean ADC, 1.07×10-3 mm(2)/s), NAWM (mean ADC, 0.83×10-3 mm(2)/s). We found a significant difference in ADC values of gray, WM lesions and NAWM in TSC patients compared to the control group (p<0,0001). Elevated ADC values in NAWM in TSC patients may be caused by subtle depletion of myelin sheaths and looseness of structures within the brain parenchyma due to underlying migration disorders.

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“…Diffusion MRI, a functional imaging technique, allows examination of tissue microstructure and provides complementary structural visualization. Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI), has been utilized as a biomarker in various neuro-pathological diseases [1]. A sensitization of DTI to subtle disturbances in white-matter tracts has revealed the neural tracts and tumor infiltration and invasion on healthy tissue [2].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Texture Analysis: Optimal Feature Selection in Classifying Child Brain Tumors

et al. 2014

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Abstract-Textural feature based classification has shown that magnetic resonance images can characterize histological brain tumor types. Feature selection is an important process to acquire a robust textural feature subset and enhance classification rate. This work investigates two different feature selection techniques; principal component analysis (PCA), and the combination of max-relevance and min-redundancy (mRMR) and feedforward selection. We validated these techniques based on a multi-center dataset of pediatric brain tumor types; medulloblastoma, pilocytic astrocytoma and ependymoma, and investigated the accuracy of tumor classification, based on textural features of diffusion and conventional MR images.

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Diagnostic Value of Diffusion-Weighted Magnetic Resonance Imaging in Pediatric Cerebral Diseases

Cited by 17 publications

References 39 publications

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema

Apparent Diffusion Coefficient is Increased in Children with Tuberous Sclerosis Complex Personal Experience and Review of the Literature

Magnetic Resonance Texture Analysis: Optimal Feature Selection in Classifying Child Brain Tumors

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