2007
DOI: 10.1016/j.diagmicrobio.2007.04.009
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Diagnostic value of DNA, (1-3)-β-d-glucan, and galactomannan detection in serum and bronchoalveolar lavage of mice experimentally infected with Aspergillus terreus

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Cited by 26 publications
(19 citation statements)
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“…qPCR was also shown to be highly sensitive in early detection in a guinea pig model of IA, with levels rapidly reaching a plateau before becoming undetectable on day 6 12. These are in contrast to a previous study that demonstrated that galactomannan (80%) was more sensitive than qPCR (63%) in the serum of untreated infected rats 13. However, in this study both the clinical specimen and the DNA extraction method were inferior to our methodology, which may account for their reduced sensitivity of qPCR.…”
Section: Discussioncontrasting
confidence: 73%
“…qPCR was also shown to be highly sensitive in early detection in a guinea pig model of IA, with levels rapidly reaching a plateau before becoming undetectable on day 6 12. These are in contrast to a previous study that demonstrated that galactomannan (80%) was more sensitive than qPCR (63%) in the serum of untreated infected rats 13. However, in this study both the clinical specimen and the DNA extraction method were inferior to our methodology, which may account for their reduced sensitivity of qPCR.…”
Section: Discussioncontrasting
confidence: 73%
“…Direct comparisons between molecular methods and the GM assay for the detection of aspergillosis do not yield consistent results as to which test is best [8,23]. However, Suarez et al report that in comparison to GM test, the PCR assay was found to be highly sensitive and specific for the early diagnosis of IA in high-risk patients with hematological disorders [24].…”
Section: Discussionmentioning
confidence: 99%
“…In other words, the combination seems to be useful to identify false-positive reactions for each test. Several studies of animal models seem to confirm this observation (1,88), but further clinical studies are needed to evaluate the cost-effectiveness of this approach. Finally, it is important that neither the BG nor GM assay detects zygomycetes, a rare but emerging cause of invasive fungal mycosis (24).…”
Section: Vol 23 2010 Non-culture-based Diagnosis Of Sepsis 243mentioning
confidence: 95%