Diagnostic value of hematological parameters platelet to lymphocyte ratio and hemoglobin to platelet ratio in patients with colon cancer

Hu, Zuojian; Tan, Shaolin; Chen, Siyuan; Qin, Simeng; Huang, Zhili; Zhou, Fengyuan; Qin, Xue

doi:10.1016/j.cca.2019.11.036

Cited by 33 publications

(25 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, increasing studies reported that routine blood examination could provide rich and effective information to assist risk stratification of disease [10,11].The promising index neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) conveyed a systematic inflammatory response in our body and has been evidenced as predictive and prognostic factors for DM and the related complications [12][13][14][15]. Moreover, Hemoglobin (Hb) was also a well-established biomarker for DR [16,17].…”

Section: Introductionmentioning

confidence: 99%

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Wang

Chen

Yang

et al. 2020

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background: Diabetic retinopathy (DR) is a specific neurovascular complication of diabetes mellitus (DM). Clinically, family history is a widely recognized risk factor for DR, assisting diagnosis and risk strata. However, among a great amount of DR patients without hereditary history like hypertension and diabetes, direct and simple risk factors to assist clinical decisions are still required. Herein, we intend to investigate the associated risk factors for these DR patients based on systemic inflammatory response indexes, neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR). Methods: We consecutively enrolled 1030 patients with a definite diagnosis of type 2 diabetes mellitus (T2DM) from the endocrinology department of the Second hospital of People in Yun Nan. Based on funduscopy and family history checking, we excluded patients with a family history of hypertension and diabetes and finally enrolled 264 patients with DR and 206 patients with non-diabetic retinopathy (NDR). Through correlation analysis, univariate and multivariate regression, we further explore the association between NLR, PLR, and DR. On top of that, we investigate the effect of NLR and PLR on risk reclassification of DR. Results: Compared with NDR patients, NLR and PLR levels are significantly higher among DR patients (NLR: 2.36 ± 1.16 in DR group versus 1.97 ± 1.06 in NDR group, p < 0.001; PLR: 11.62 ± 4.55 in DR group versus10.56 ± 4.45 in NDR group, p = 0.012). According to univariate analysis, NLR and PLR add risks to DR. After fully adjusting co-founders, NLR, as both continuous and categorical variate, remains an independent risk factor for DR (OR (95%CI): 1.37 (1.06, 1.78) P = 0.018). And though PLR was not independently associated with DR as a continuous variable (OR (95%CI) 1.05 (0.99, 1.11) p = 0.135), the highest quantile of PLR add twofold increased risk (OR (95%CI) 2.20 (1.05, 4.59) p = 0.037) in the fully adjusted model for DR. In addition, addition of PLR and NLR to the established factor hemoglobin (Hb) improved the discriminability of the model and assisted the reclassification of DR. After combining PLR and NLR the

show abstract

Section: Introductionmentioning

confidence: 99%

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Wang

Chen

Yang

et al. 2020

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Recently, increasing studies reported that routine blood examination could provide rich and effective information to assist risk stratification of disease [10][11].The promising index neutrophil-tolymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (PLR) conveyed a systematic inflammatory response in our body and has been evidenced as predictive and prognostic factors for DM and the related complications [12][13][14][15]. Moreover, Hemoglobin(Hb) was also a well-established biomarker for DR [16][17].…”

Section: Introductionmentioning

confidence: 99%

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Wang

Chen

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Diabetic retinopathy (DR) is a specific neurovascular complication of diabetes mellitus (DM). Clinically, family history is a widely recognized risk factor for DR,assisting diagnosis and risk strata. However, among a great amount of DR patients without hereditary history like hypertension and diabetes, direct and simple risk factors to assist clinical decisions are still required. Herein, we intend to investigate the associated risk factors for these DR patients based on systemic inflammatory response indexes, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Methods: We consecutively enrolled 1030 patients with a definite diagnosis of type 2 diabetes mellitus(T2DM) from the endocrinology department of the Second hospital of People in Yun Nan. Based on funduscopy and family history checking, we excluded patients with a family history of hypertension and diabetes and finally enrolled 264 patients with DR and 206 patients with non diabetic retinopathy(NDR).Through correlation analysis, univariate and multivariate regression, we further explore the association between NLR, PLR, and DR. On top of that we investigate the effect of NLR and PLR on risk reclassification of DR. Results: Compared with NDR patients, NLR and PLR levels are significantly higher among DR patients (NLR:2.36±1.16 in DR group versus 1.97±1.06 in NDR group, p<0.001; PLR: 11.62±4.55 in DR group versus10.56±4.45 in NDR group, p=0.012). According to univariate analysis, NLR and PLR add risks to DR. After fully adjusting co-founders, NLR, as both continuous and categorical variate, remains an independent risk factor for DR(OR(95%CI):1.37 (1.06,1.78) P= 0.018). And though PLR not independently associated with DR as a continuous variable (OR (95%CI)1.05 (0.99, 1.11) p=0.135 ), the highest quantile of PLR add two-fold increased risk (OR(95％CI) 2.20 (1.05, 4.59) p=0.037) in the fully adjusted model for DR. In addition, addition of PLR and NLR to the established factor hemoglobin (Hb) improved the discriminability of the model and assisted the reclassification of DR. After combining PLR and NLR the Area under curve (AUC) of Hb based model raised from 0.76 to 0.78, with a category-free net reclassiﬁcation improvement (NRI) of 0.532 (p < 0.001) and Integrated discrimination improvement (IDI) of 0.029(p < 0.001). Conclusions: Systemic inflammatory response indexes NLR and PLR were associated with the presence of DR among patients without associated family history and contributed to improvements in re-classification in addition to Hb.

show abstract

“…Mekanisme yang mendasari hal ini adalah adanya kondisi anemia dan trombositosis yang didapatkan pada pasien dengan keganasan, sehingga nilai RHP yang rendah berhubungan dengan prognostik yang lebih buruk. [27][28][29] Adapun prognostik nilai RHP belum pernah diteliti apakah memiliki terhadap penyakit kardiovaskular, khususnya SKA. Pada sebagian besar pasien dengan penyakit jantung, anemia akibat penyakit kronik seringkali ditemukan.…”

Section: Diskusiunclassified

Korelasi Rasio Hemoglobin Platelet dan Rasio Leukosit Platelet terhadap Skor SYNTAX-2 pada Pasien Infark Miokard Akut dengan ST-Elevasi

Ikhsan¹,

Nasution

Rachman

et al. 2021

JPDI

View full text Add to dashboard Cite

Pendahuluan. Berbagai penelitian telah melakukan analisis hubungan dan nilai prediksi antara berbagai penanda inflamasi dengan luaran klinis pasien infark miokard akut dengan ST elevasi (IMA-STE). Namun, pemeriksaan yang cukup mahal maupun ketersediaan di fasilitas kesehatan menjadi kendala untuk dilakukan pemeriksaan penanda inflamasi tersebut. Oleh karena itu, penelitian ini bertujuan melihat apakah parameter hematologi sederhana dalam hal ini rasio hemoglobin platelet (RHP) dan rasio leukosit platelet (RLP) yang juga terlibat dalam patofisiologi SKA berkorelasi dengan skor synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX-2) sebagai prediktor luaran klinis dan mortalitas pada pasien IMA-STE.Metode. Penelitian potong lintang pada pasien IMA-STE yang dirawat di ICCU RSCM kurun waktu Januari 2016 -Oktober 2020. Data dianalisis dengan uji korelasi antara RHP maupun RLP dengan skor SYNTAX-2.Hasil. Terdapat 114 subjek dalam penelitian ini, dengan rerata usia 53,87 tahun dan sebagian besar adalah pria (86,8%). Tidak didapatkan korelasi yang bermakna antara RHP maupun RLP dengan skor SYNTAX-2. Dari analisis sub-grup, didapatkan korelasi positif sedang antara RHP dengan skor SYNTAX-2 (r = 0,587; p= 0,005) dan korelasi positif kuat antara RLP dengan skor SYNTAX-2 (r = 0,606; p = 0,004) pada subjek dengan indeks massa tubuh (IMT) normal. Adapun hasil tambahan didapatkan korelasi negatif kuat antara rasio neutrofil limfosit (RNL) dengan skor SYNTAX-2 (r = -0,738; p= 0,0037) dan korelasi negatif sangat kuat antara rasio platelet limfosit (RPL) dengan skor SYNTAX-2 (r= -0,857; p= 0,007) pada IMT underweight.Simpulan. Tidak didapatkan korelasi antara RHP maupun RLP dengan skor SYNTAX-2.

show abstract

Diagnostic value of hematological parameters platelet to lymphocyte ratio and hemoglobin to platelet ratio in patients with colon cancer

Cited by 33 publications

References 23 publications

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Korelasi Rasio Hemoglobin Platelet dan Rasio Leukosit Platelet terhadap Skor SYNTAX-2 pada Pasien Infark Miokard Akut dengan ST-Elevasi

Contact Info

Product

Resources

About