Diagnostic Value of IgA Antibody Measurement in Tick-Borne Spotted Fever (Astrakhan Rickettsial Fever)

Smirnova, Nina S; Kostarnoy, Alexey V; Kondratev, Alexey V; Gancheva, Petya G.; Grumov, Daniil A; Gintsburg, Alexander L.

doi:10.1128/spectrum.01687-21

Cited by 1 publication

(2 citation statements)

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“…B cells produce different isotypes of immunoglobulins, but the main subclasses of diagnostic importance have been IgM (early phase) and IgG (later phase). However, IgA has recently shown considerable diagnostic value for tick-borne spotted fever rickettsial in the early phase [16,60].…”

Section: Humoral Immunitymentioning

confidence: 99%

“…Developing and emerging countries are expected to have higher densities of ticks, which predisposes to a more significant occurrence of tick-associated diseases. This association is evident not only in some regions of Brazil but also in other countries such as China [14], India [15], and Russia [16], but it is not the predominant factor since several developed countries also present an increase of incidence [1]. Instead, this may be explained by social reasons (modifications in human behavior, duration and type of leisure activities, increased tourism in high-risk areas) and ecological factors (e.g., effects of climate change on the tick population and reservoir animals).…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in the Immunologic Method Applied to Tick-Borne Diseases in Brazil

De-Simone

Chino

2022

Pathogens

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Zoonotic-origin infectious diseases are one of the major concerns of human and veterinary health systems. Ticks, as vectors of several zoonotic diseases, are ranked second only to mosquitoes as vectors. Many ticks’ transmitted infections are still endemic in the Americas, Europe, and Africa and represent approximately 17% of their infectious diseases population. Although our scientific capacity to identify and diagnose diseases is increasing, it remains a challenge in the case of tick-borne conditions. For example, in 2017, 160 cases of the Brazilian Spotted Fever (BSF, a tick-borne illness) were confirmed, alarming the notifiable diseases information system. Conversely, Brazilian borreliosis and ehrlichiosis do not require notification. Still, an increasing number of cases in humans and dogs have been reported in southeast and northeastern Brazil. Immunological methods applied to human and dog tick-borne diseases (TBD) show low sensitivity and specificity, cross-reactions, and false IgM positivity. Thus, the diagnosis and management of TBD are hampered by the personal tools and indirect markers used. Therefore, specific and rapid methods urgently need to be developed to diagnose the various types of tick-borne bacterial diseases. This review presents a brief historical perspective on the evolution of serological assays and recent advances in diagnostic tests for TBD (ehrlichiosis, BSF, and borreliosis) in humans and dogs, mainly applied in Brazil. Additionally, this review covers the emerging technologies available in diagnosing TBD, including biosensors, and discusses their potential for future use as gold standards in diagnosing these diseases.

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Section: Humoral Immunitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Immunologic Method Applied to Tick-Borne Diseases in Brazil

De-Simone

Chino

2022

Pathogens

View full text Add to dashboard Cite

show abstract

Diagnostic Value of IgA Antibody Measurement in Tick-Borne Spotted Fever (Astrakhan Rickettsial Fever)

Abstract: Tick-borne spotted fevers caused by Rickettsia occur worldwide. The symptoms of this bacterial infection are similar to the symptoms of viral infection, and thus, diagnostic accuracy has special clinical importance.

Cited by 1 publication

References 39 publications

Recent Advances in the Immunologic Method Applied to Tick-Borne Diseases in Brazil

Recent Advances in the Immunologic Method Applied to Tick-Borne Diseases in Brazil

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