Diagnostic Value of Immature Myeloid Information in Early-onset Bacterial Infection in Term and Preterm Neonates

Neunhoeffer, Felix; Dabek, M. T.; Renk, Hanna; Rimmele, P.; Poets, Christian F.; Goelz, Rangmar; Orlikowsky, Thorsten

doi:10.1055/s-0034-1395552

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…The results of this paper showed that preterm birth, unexplained asphyxia, fecal contamination of amniotic fluid, maternal infection during pregnancy, and premature rupture of membranes ≥18 h were significantly associated with EONBI. Preterm delivery has been reported as a high risk factor significantly associated with EONBI and 64% of fecal contamination of amniotic fluid is associated with chorioamnionitis ( 11 ). The present study confirmed this finding, analyzing the reasons for this, premature infants have immature immune systems and all systems, and are more likely to acquire infections via the above-mentioned routes or through the skin and respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Obstetric Risk Factors and Serological Characteristics of Early-Onset Neonates Bacterial Infections

Wang

Chen²,

Xu³

et al. 2022

Front. Surg.

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PurposeTo analyze the obstetric high-risk factors and serological characteristics of early-onset neonatal bacterial infections (EONBI).Methods119 neonates with early-onset bacterial infection who were admitted to the neonatal ward of our hospital from October 2020 to December 2021 were recorded as the study group, and 100 neonates without bacterial infection who were admitted during the same period were used as the reference group. Comparative analysis of obstetric high-risk factors and serological characteristics of EONBI.ResultsThere was no statistical difference between the two groups in terms of gender and age at admission (P > 0.05). The gestational age and birth weight of newborns in the study group were lower than those in the reference group (P < 0.001). Comparing the maternal factors of EONBI between the two groups, there was no statistical difference in age, number of obstetric inspections, whether to use antibiotics, and mode of delivery (P > 0.05). Univariate analysis showed that preterm birth, unexplained asphyxia, fecal contamination of amniotic fluid, maternal infection during pregnancy, and premature rupture of membranes ≥18 h were significantly associated with EONBI (P < 0.05); while there was no significant difference between the two groups in the comparison between diabetic mother and child and maternal fever at delivery (P > 0.05). Multifactorial analysis showed that preterm birth, fecal contamination of amniotic fluid, maternal infection during pregnancy, and premature rupture of membranes ≥18 h had a good multivariate dependence on EONBI (P < 0.05), while there was no significant association with unexplained asphyxia, diabetic mother and child, and maternal fever at delivery (P > 0.05). The incidence of neonatal temperature >37.9°C was higher in the study group than in the reference group (P < 0.05), and there were no statistical differences in the comparison of other clinical manifestations (P > 0.05). The CRP level of neonates in the study group (47.33 ± 4.14) mg/L was higher than that of the reference group (4.84 ± 1.03) mg/L (P < 0.001). The WBC level of neonates in the study group (5.64 ± 1.18) 109/L was higher than that of the reference group (0.28 ± 0.04) 109/L (P < 0.001). The PCT level of neonates in the study group (5.41 ± 0.85) µg/L was higher than that of the reference group (0.24 ± 0.07) µg/L (P < 0.001).ConclusionEONBI is closely associated with several obstetric high-risk factors, including preterm birth, fecal contamination of amniotic fluid, maternal infection during pregnancy, and premature rupture of membranes ≥18 h; EONBI has no specific symptoms and signs, but serum CRP, WBC, and PCT levels are significantly higher than those of newborns without co-infection with bacteria.

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Section: Discussionmentioning

confidence: 99%

Obstetric Risk Factors and Serological Characteristics of Early-Onset Neonates Bacterial Infections

Wang

Chen²,

Xu³

et al. 2022

Front. Surg.

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“…Der IMI-Kanal bestimmt die absolute Zahl und/oder den Anteil an unreifen Neutrophilen anhand des geringeren Phospholipidgehaltes in der Membran. In den wenigen bisher dazu veröffentlichten Studien bei Neugeborenen wurde eine Sensitivität von 33 -84 % und eine Spezifität von 54 -88 % angegeben [9].…”

Section: Neutrophilenneubildungunclassified

Rationelle Diagnostik und Antibiotika-Therapie der Neugeborenensepsis

Gille¹,

Orlikowsky²

2018

Neonatologie Scan

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Diagnostic Value of Immature Myeloid Information in Early-onset Bacterial Infection in Term and Preterm Neonates

Abstract: The diagnostic value of IMI in diagnosing EOBI in preterm and term neonates is not comparable to IL-6, IL-8 and CRP. Combination of IMI-Channel with IL-6, IL-8 or CRP improves their sensitivity, specificity and predictive value.

Cited by 2 publications

References 30 publications

Obstetric Risk Factors and Serological Characteristics of Early-Onset Neonates Bacterial Infections

Obstetric Risk Factors and Serological Characteristics of Early-Onset Neonates Bacterial Infections

Rationelle Diagnostik und Antibiotika-Therapie der Neugeborenensepsis

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