Diagnostic value of interferon-<i>γ</i> release assay in HIV-infected individuals complicated with active tuberculosis: a systematic review and meta-analysis

Ma, Yiyun; Xu, Yuni; Cao, Xiaoqiang; Chen, Xiaojuan; Zhong, Yeteng

doi:10.1017/s0950268821001953

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…A challenging issue in HIV-TB coinfection is the atypical presentation of TB [ 40 ]. While the conventional sputum-based detection of TB is of limited scope in these patients and often leads to false negativity [ 41 ], interferon gamma (IFN-γ)-based assays, though specific [ 42 ], are more expensive. Thus, several studies have applied transcriptomics, particularly the altered or differentially expressed protein-coding genes between HIV and HIV-TB patients, to identify biological markers for TB in HIV patients [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of lncRNAs in HIV Patients with TB and HIV-TB with Anti-Retroviral Treatment

Reid,

Ramos,

Veerapandian

et al. 2024

ncRNA

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Tuberculosis (TB) is the leading cause of death among people with HIV-1 infection. To improve the diagnosis and treatment of HIV-TB patients, it is important to understand the mechanisms underlying these conditions. Here, we used an integrated genomics approach to analyze and determine the lncRNAs that are dysregulated in HIV-TB patients and HIV-TB patients undergoing anti-retroviral therapy (ART) using a dataset available in the public domain. The analyses focused on the portion of the genome transcribed into non-coding transcripts, which historically have been poorly studied and received less focus. This revealed that Mtb infection in HIV prominently up-regulates the expression of long non-coding RNA (lncRNA) genes DAAM2-AS1, COL4A2-AS1, LINC00599, AC008592.1, and CLRN1-AS1 and down-regulates the expression of lncRNAs AC111000.4, AC100803.3, AC016168.2, AC245100.7, and LINC02073. It also revealed that ART down-regulates the expression of some lncRNA genes (COL4A2-AS1, AC079210.1, MFA-AS1, and LINC01993) that are highly up-regulated in HIV-TB patients. Furthermore, the interrogation of the genomic regions that are associated with regulated lncRNAs showed enrichment for biological processes linked to immune pathways in TB-infected conditions. However, intriguingly, TB patients treated with ART showed completely opposite and non-overlapping pathways. Our findings suggest that lncRNAs could be used to identify critical diagnostic, prognostic, and treatment targets for HIV-TB patients.

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Section: Discussionmentioning

confidence: 99%

Differential Expression of lncRNAs in HIV Patients with TB and HIV-TB with Anti-Retroviral Treatment

Reid,

Ramos,

Veerapandian

et al. 2024

ncRNA

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“…показали эффективность лабораторного метода Т-СПОТ.ТБ в выявлении ЛТИ у взрослых пациентов в Самарской области [26]. Высокая эффективность IGRA-тестов у ВИЧ-инфицированных лиц отмечена по результатам метаанализа, проведенного Y. Ma et al [27]. В работе A.C. Pettit et al [28] показано, что методика ELISPOT (тест Т-СПОТ.ТБ) имеет более высокую положительную прогностическую значимость для этой категории пациентов.…”

Section: туберкулезunclassified

Latent tuberculosis infection in risk groups of the adult population of the Saratov Region

Morozova

Doktorova²

2023

Medicinskij sovet

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Introduction. The priority of anti-tuberculosis work in the Saratov Region is the early detection of the disease and the prevention of new cases of pathology. The presence of medical and social risk factors for developing tuberculosis significantly increases the risk of developing local forms of tuberculosis, especially if patients have latent tuberculosis infection (LTBI).Aim. To assess the prevalence of LTBI in the adult population with an increased risk of developing tuberculosis in the adult population.Materials and methods. The design of the study is a retrospective non-comparative. The data of patients from high-risk groups for the development of the disease for the period of 2015–2019, examined using a skin test with a recombinant tuberculosis allergen (Diaskintest, Generium JSC, Russia) in the Saratov Region, were analyzed.Results. 153,120 people from medical outpatient risk groups and 3,099 people from social risk groups were examined. Among adults with medical risk factors for developing tuberculosis, the largest number of positive and doubtful results of Diaskintest were recorded in patients with chronic bronchopulmonary pathology – 15.88%; among the group of those surveyed with social risk factors for developing tuberculosis – in persons released from penitentiary institutions (25.88%).Conclusions. The decrease in incidence rates in the Saratov Region confirms the correctness of the chosen tactics regarding the use of the Diaskintest test to identify individuals with LTBI among the adult population and the implementation of measures to reduce the reservoir of tuberculosis infection. Given the effectiveness of the measures taken, it is advisable to work with risk groups for Diaskintest and further examination in a general medical network. To do this, it is necessary to make additions to the current Order of the Ministry of Health of the Russian Federation dated March 21, 2017 No. 124n “On approval of the procedure and terms for conducting preventive medical examinations of citizens in order to detect tuberculosis” regarding the use of recombinant tuberculosis allergen samples in the adult population.

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“…However, this hypothesis was ruled out because of positive STN-PCR results for M. tuberculosis. Based on a meta-analysis study conducted by Ma, et al, (2021), IGRA is more sensitive in detecting TB in HIV-positive patients compared to TST, which can cause falsenegative results. However, in this patient, the TST result was positive and the IGRA result was negative.…”

Section: The Role Of Using Tst and Igra For The Diagnosis Of Tubercul...mentioning

confidence: 99%

TUBERCULIN SKIN TEST AND INTERFERON-γ RELEASE ASSAY ON THE DIAGNOSIS OF TUBERCULOUS SPONDYLITIS

Hadid,

Faris,

Betty Agustina Tambunan

2023

MBIOMJ

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Highlights TST and IGRA have a significant correlation with the diagnosis of patients with Tuberculous Spondylitis. Various factors may affect the results of TST and IGRA. Thus, the use of TST and IGRA can be adjusted according to the condition of the hospital, the availability of diagnostic tools, the health worker’s physical examination results, and the patient's medical history. Abstract Background: Tuberculous spondylitis or Pott’s disease is extrapulmonary tuberculosis that is still a concern to health workers because of the broad spectrum of its clinical symptoms. Delay in diagnosis is very common in this disease. Therefore, its diagnostic tool needs to be thoroughly reviewed to determine its effectiveness. The diagnostic tools studied in this study were Tuberculin Skin Test (TST) and Interferon-γ Release Assay (IGRA). Objective: To analyze the role of TST and IGRA as diagnostic tools for the diagnosis of tuberculous spondylitis. Material and Method: This study used a systematic review method to analyze topic-related kinds of literature written in English and Indonesian found on PubMed, Scopus, ProQuest, and Web of Science databases. The literature screening process was carried out based on the PRISMA 2020 Guidelines. Result: Sixteen types of literature were included for a total of 116 patients. TST was detected positive in 45 (63%) and negative in 21 (30%) of a total of 66 patients with Pott’s disease. IGRA was detected positive in 51 (77%), negative in 8 (12%), and indeterminate in 2 (3%) of a total of 61 patients with Pott’s disease. Conclusion: TST and IGRA results significantly correlate with the diagnosis of tuberculous spondylitis. Both tests are still relevant for use in the diagnosis of the disease. IGRA and TST are used according to the needs of health workers and patients’ health backgrounds.

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Diagnostic value of interferon-γ release assay in HIV-infected individuals complicated with active tuberculosis: a systematic review and meta-analysis

Cited by 5 publications

References 32 publications

Differential Expression of lncRNAs in HIV Patients with TB and HIV-TB with Anti-Retroviral Treatment

Differential Expression of lncRNAs in HIV Patients with TB and HIV-TB with Anti-Retroviral Treatment

Latent tuberculosis infection in risk groups of the adult population of the Saratov Region

TUBERCULIN SKIN TEST AND INTERFERON-γ RELEASE ASSAY ON THE DIAGNOSIS OF TUBERCULOUS SPONDYLITIS

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