Diagnostic value of methylation status of T-UCRs for colorectal cancer

Κοττόρου, Αναστασία; Antonacopoulou, Anna G.; Dimitrakopoulos, Foteinos-Ioannis; Διαμαντοπούλου, Γεωργία; Theodorakopoulos, Theodoros; Oikonomou, Chrysa; Koukourikou, I.; Dalla, D.; Karatasou, P.; Katsakoulis, Evangelos; Koutras, A.; Makatsoris, Thomas; Stavropoulos, M.; Thomopoulos, K.; Kalofonos, Haralabos

doi:10.1093/annonc/mdw370.118

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“…Additionally, lncRNAs showing aberrant DNA methylation may serve as potential epigenetically-based diagnostic factors. Silencing from CpG-island methylation of promoter-induced transcribed ultraconserved regions (T-UCRs) is common in many tumors and linked to colorectal cancer diagnosis (Kottorou et al, 2016;Honma et al, 2017). Therefore, elucidating the relationship between DNA methylation and lncRNA expression is essential for understanding GC development and potentially identifying new prognostic or diagnostic markers.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification and Characterization of DNA Methylation and Long Non-Coding RNA Expression in Gastric Cancer

Song

Guan

2020

Front. Genet.

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Abnormal DNA methylation, an epigenetic modification, has increasingly been linked to the pathogenesis of many human cancers. However, there has been little focus on the DNA methylation patterns of genes encoding long noncoding RNAs (lncRNAs) in gastric cancer (GC). This study comprehensively determined DNA methylation and lncRNA expression profiles in GC through genome-wide analysis. Differentially methylated loci and lncRNAs were identified by integrating multi-omics data. In total, 548 differentially methylated CpG sites in lncRNA promoters and 2,399 differentially expressed lncRNAs were screened that were capable of distinguishing GC from normal tissues. Among them, 22 differentially methylation sites in 17 lncRNAs were inversely related to expression levels. Further analysis of DNA methylation status and gene expression level in GC revealed that three CpG sites (cg01550148, cg22497867, and cg20001829) and two lncRNAs (RP11-366F6.2 and RP5-881L22.5) were significantly associated with GC patient overall survival. Molecular function analysis showed that these abnormally methylated lncRNAs were mainly involved in transcriptional activator activity. Our study identified several lncRNAs regulated by aberrant DNA methylation that have clinical utility as novel prognostic biomarkers in GC. These findings help improve the understanding of methylated patterns of lncRNAs and further our knowledge of the role of epigenetics in cancer development.

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Section: Introductionmentioning

confidence: 99%