Diagnostic Value of MicroRNA-18a for Gastric Cancer: a Meta-Analysis

Liang, Qindong; Zhang, Guangjie; Wang, Jing; Sheng, Shangchun

doi:10.7754/clin.lab.2017.170827

Cited by 4 publications

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“…Increased circulating miR-18a may also be a prognostic factor for lung cancer (18). A meta-analysis revealed that miR-18a may be a promising biomarker for the diagnosis of patients with gastric carcinoma (19). The results obtained in the current study are in accordance with the aforementioned studies.…”

Section: Discussionsupporting

confidence: 90%

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

Zhuo

Zhou

et al. 2019

Oncol Lett

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Increasing evidence has revealed the importance of microRNA (miRNA/miR) in cancer genesis and progression. The aim of the current study was to identify the key miRNAs involved in the onset and development of nasopharyngeal carcinoma (NPC) and to further evaluate their diagnostic and prognostic values. Microarray data were obtained and analyzed to screen differentially expressed miRNAs (DEMs) between patients with NPC and healthy controls. The target genes of the DEMs were predicted and their possible functions were evaluated. The diagnostic and prognostic values of the DEMs were subsequently investigated. A total of 4 DEMs, including miR-18a, miR-135b, miR-204 and miR-497, were identified. Gene Ontology (GO) and pathway enrichment analysis revealed that the target genes were enriched in a number of GO terms and signaling pathways. The results demonstrated that the selected DEMs may present potential diagnostic factors for NPC. In addition, miR-18a [Hazard ratio (HR), 3.405; 95% confidence interval (CI), 1.334-8.693] and miR-135b (HR, 2.482; 95% CI, 1.014-6.076) may serve prognostic roles for patients with NPC. In summary, the present study identified 4 miRNAs that may be involved in the genesis and development of NPC. In addition, miR-18a and miR-135b may present useful prognostic markers for patients with NPC. Future in vitro and in vivo investigations are warranted to substantiate the results obtained in the current study.

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Section: Discussionsupporting

confidence: 90%

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

Zhuo

Zhou

et al. 2019

Oncol Lett

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MicroRNA a small magic bullet for gastric cancer

Verma

Bhaskar

2020

Gene

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MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10

Wang¹,

Lu²,

Cao³

et al. 2018

OTT

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BackgroundHepatocellular carcinoma (HCC) is known to feature several microRNA dysregulations. This study aimed to determine and investigate the prognostic value of microRNA (miRNA/miR)-18a and its role in regulating the progression of HCC.MethodsmiR-18a expressions in human HCC tissues, pair-matched adjacent normal liver tissues as well as in HCC cell lines were determined by quantitative real-time PCR. The prognostic value of miR-18a was determined using Kaplan–Meier survival analysis and multivariable Cox regression assay. The ability of miR-18a in promoting HCC progression was verified in vitro.ResultsmiR-18a expressions in HCC tissues and cells were more than twice those of the normal control group (P<0.05). miR-18a expression was associated with the alpha-fetoprotein (AFP) level, TNM stage, tumor size, and intrahepatic vascular invasion (P<0.05). Kaplan– Meier survival analysis revealed that HCC patients with high expression of miR-18a possessed a more unfavorable prognosis (log-rank P<0.001). Overexpression of miR-18a promoted cell apoptosis and proliferation, induced S phase transition, as well as enhanced the migration and invasion ability of HCC cells. miR-18a was found to directly target the downstream molecule Bcl2L10. Furthermore, overexpressing Bcl2L10 was able to partly reverse the promoting effects of miR-18a on HCC cell progression.ConclusionmiR-18a may serve as a prognostic biomarker of HCC as it is demonstrated to carry out a decisive role in HCC progression by promoting HCC cell invasion, migration, and proliferation through targeting Bcl2L10.

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Diagnostic Value of MicroRNA-18a for Gastric Cancer: a Meta-Analysis

Abstract: miR-18a could be a promising noninvasive biomarker in gastric carcinoma diagnosis. Further prospective studies should be conducted to highlight the theoretical strengths before its use in clinic.

Cited by 4 publications

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Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

MicroRNA a small magic bullet for gastric cancer

MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10

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