Diagnostic value of MRI in comparison to scintigraphy, PET, MS-CT and PET/CT for the detection of metastases of bone

Ghanem, Nadir; Uhl, Markus; Brink, Ingo; Schäfer, Oliver; Kelly, Thomas M.; Moser, E.; Langer, Mathias

doi:10.1016/j.ejrad.2005.01.016

Cited by 173 publications

(106 citation statements)

References 57 publications

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“…A study by Nemeth et al reported 100% specificity for DW MRI in detecting skull metastasis [4] . It was found that DW MRI was comparable to or more sensitive than FDG-PET/ CT [5,6] . Moreover, Mosavi et al found that whole body DWI MRI has higher specificity than NaF 18 PET/CT for detection of bone metastases caused by prostate cancer [7] .…”

Section: Discussionmentioning

confidence: 99%

Characterization of a parietal lesion detected by diffusion weighted MRI, NaF18-PET/CT and CT

Win

Aparici

2013

JBGC

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It is very important to accurately characterize skull lesions so that appropriate treatment decisions can be made. False positive readings may lead to unnecessary surgical intervention or radiation. We present a case of a parietal lesion seen on Diffusion weighted (DW) MRI, and further characterized with NaF18-PET/CT and CT in a 69 year old male. This is the first case to report the use of DW MRI, NaF18-PET/CT bone scan and CT in the diagnosis of a skull lesion. DW MRI is known to have high specificity to detect malignant lesions in the skull. If a similar case such as ours in encountered in everyday clinical practice, a differential diagnosis of a benign etiology should be considered.

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Section: Discussionmentioning

confidence: 99%

Characterization of a parietal lesion detected by diffusion weighted MRI, NaF18-PET/CT and CT

Win

Aparici

2013

JBGC

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“…PET-CT appears to be slightly less sensitive than whole body MRI in the detection of osteal metastases (Ghanem et al, 2005). Already a trial of whole-body simultaneous hybrid PET/MRI was performed for neoplastic lesions, and simultaneous PET/MRI is a promising technology for the detection of neoplastic disease (Rakheja et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Recurrence and Metastasis of Lung Cancer Demonstrate Decreased Diffusion on Diffusion-Weighted Magnetic Resonance Imaging

Usuda¹,

Sagawa²,

Motomo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or metastasis of lung cancer. Methods: A total of 36 lung cancer patients with recurrence or metastasis were enrolled in this study. While 16 patients underwent magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography-computed tomography (PET-CT), 17 underwent MRI and CT, and 3 underwent MRI and PET-CT. Results: Each recurrence or metastasis showed decreased diffusion, which was easily recognized in DWI. The detection rate for recurrence or metastasis was 100% (36/36) in DWI, 89% (17/19) in PET-CT and 82% (27/33) in CT. Detection rate of DWI was significantly higher than that of CT (p=0.0244) but not significantly higher than that of PET-CT (p=0.22). When the optimal cutoff value of the apparent diffusion coefficient value was set as 1.70×10 -3 mm 2 /sec, the sensitivity of DWI for diagnosing recurrence or metastasis of lung cancer was 95.6%. Conclusions: DWI is useful for detection of recurrence and metastasis of lung cancer.

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“…Moreover, bone scintigraphy is associated with radiation exposure. A study by Ghanem et al [9] showed that the effective dose which is absorbed by patients undergoing a scintigraphy of the skeleton is estimated at 4 millisieverts. High costs, a considerable effort, and a burdensome procedure for the patient are the other important disadvantages of bone scintigraphy [7] (Figures 1 and 2).…”

Section: Introductionmentioning

confidence: 99%

“…In regards to the diagnostics of bone metastases of RCC, bone scintigraphy is the gold standard [2,7]. Despite good sensitivity, bone scintigraphy lacks specificity [8,9]. Moreover, bone scintigraphy is associated with radiation exposure.…”

Section: Introductionmentioning

confidence: 99%

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2014

Integr Cancer Sci Therap

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The objective of this study was to assess the diagnostic value of the bone resorption marker tartrate-resistant acid phosphatase isoform5b (TRACP 5b) in detecting bone metastases in patients with renal cell carcinoma (RCC). Serum samples of 64 patients with histologically proven RCC were analyzed. Using bone scintigraphy, these patients were divided into 2 groups: 30 patients with RCC without bone metastases and 34 patients with RCC with bone metastases. TRACP 5b concentrations were analyzed in the serum using the Bone TRAP Assay. TRACP 5b concentrations were significantly elevated (p=0.014) in patients with bone metastases (median: 31.9 U/L) compared with patients without bone metastases (median: 8.7 U/L). Elevated TRACP 5b concentrations detected bone metastases with sensitivity of 76.5% and specificity of 36.7%. TRACP 5b appears to be an effective biomarker of bone metastases in patients with RCC.

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Diagnostic value of MRI in comparison to scintigraphy, PET, MS-CT and PET/CT for the detection of metastases of bone

Cited by 173 publications

References 57 publications

Characterization of a parietal lesion detected by diffusion weighted MRI, NaF18-PET/CT and CT

Characterization of a parietal lesion detected by diffusion weighted MRI, NaF18-PET/CT and CT

Recurrence and Metastasis of Lung Cancer Demonstrate Decreased Diffusion on Diffusion-Weighted Magnetic Resonance Imaging

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