Diagnostic Value of Nineteen Different Imaging Methods for Patients with Breast Cancer: a Network Meta-Analysis

Abstract

Background/Aims: We performed a network meta-analysis (NMA) to investigate and compare the diagnostic value of 19 different imaging methods used for breast cancer (BC). Methods: Cochrane Library, PubMed and EMBASE were searched to collect the relevant literature from the inception of the study until November 2016. A combination of direct and indirect comparisons was performed using an NMA to evaluate the combined odd ratios (OR) and draw the surface under the cumulative ranking curves (SUCRA) of the diagnostic value of different imaging methods for BC. Results: A total of 39 eligible diagnostic tests regarding 19 imaging methods (mammography [MG], breast-specific gamma imaging [BSGI], color Doppler sonography [CD], contrast-enhanced magnetic resonance imaging [CE-MRI], digital breast tomosynthesis [DBT], fluorodeoxyglucose positron-emission tomography/computed tomography [FDG PET/CT], fluorodeoxyglucose positron-emission tomography [FDG-PET], full field digital mammography [FFDM], handheld breast ultrasound [HHUS], magnetic resonance imaging [MRI], automated breast volume scanner [ABUS], magnetic resonance mammography [MRM], scintimammography [SMM], single photon emission computed tomography scintimammography [SPECT SMM], ultrasound elastography [UE], ultrasonography [US], mammography + ultrasonography [MG + US], mammography + scintimammography [MG + SMM], and ultrasound elastography + ultrasonography [UE + US]) were included in the study. According to this network meta-analysis, in comparison to the MG method, the CE-MRI, MRI, MRM, MG + SMM and UE + US methods exhibited relatively higher sensitivity, and the specificity of the FDG PET/CT method was higher, while the BSGI and MRI methods exhibited higher accuracy. Conclusion: The results from this NMA indicate that the diagnostic value of the BSGI, MG + SMM, MRI and CE-MRI methods for BC were relatively higher in terms of sensitivity, specificity and accuracy.

The effect comparisons of different exercise interventions on blood glucose and insulin resistance relative indicators for prediabetes: a network meta-analysis

“…I 2 statistics was calculated to assess the heterogeneity within studies. If there was statistical difference in heterogeneity test statistics (I 2 >50%), a random effects model was applied to calculate the pooled value, otherwise, a fixed effects model was used [17].…”

Breast cancer

“…• Рекомендуется выполнить всем пациентам ультразвуковое исследование (УЗИ) молочных желез и регионарных лимфатических узлов для оценки местного распространения РМЖ [5,21]. УУР В (УДД 1).…”

“…• Рекомендуется при наличии показаний выполнить магнитно-резонансную томографию (МРТ) молочных желез для оценки местного распространения РМЖ [21]. УУР В (УДД 1).…”

Evidence-Based PET for Breast Cancer

“…A recent network meta-analysis comparing 19 different imaging methods demonstrated the relatively higher specificity of 18 F-FDG PET/CT compared to other imaging methods for the detection of BC lesions [1].…”