Diagnostic value of optical coherence tomography for oral leukoplakia assessment

Semkin, V A; Rabinovich, O F; Agapitova, L P; Bezrukov, A A; Бабиченко, И. И.

doi:10.17116/stomat201897137-39

Stomat.

2018

DOI: 10.17116/stomat201897137-39

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Diagnostic value of optical coherence tomography for oral leukoplakia assessment

V A Semkin

O F Rabinovich

L P Agapitova

et al.

Abstract: The article presents a comparative analysis of the results of in vivo scanning of oral mucosa leukoplakia with optical coherence tomography (OCT) method and pathological studies in 15 patients (9 females and 6 males aged 27-82). The study revealed specific OCT signs of leukoplakia: even disorder of tissue layering and less clear visualization of lamina propria. OCT is an important stage in the differential diagnosis of leukoplakia of the oral mucosa and significantly complements the clinical and pathomorpholog… Show more

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2024

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Compression optical coherence elastography as a new tool for non-invasive identification of precancerous lesions of the oral mucosa

Plekhanov,

Gazhva,

Ibragimova

et al. 2024

Laser Phys. Lett.

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We demonstrate the possibilities and prospects of a new application of compression optical coherence elastography (C-OCE) for diagnosing precancerous lesions of the oral mucosa. C-OCE allows the study of nonlinear elasticity of bio-tissues and mapping of various elasticity parameters to differentiate individual morphological structures and pathologies in human tissues. This work demonstrates the first utilization of C-OCE to identify oral leukoplakia lesions in the palate and buccal mucosa using changes in epithelial stiffness caused by the development of hyperkeratosis, which leads to the appearance of a pronounced keratin layer on the surface of the lesions. C-OCE-based quantification of characteristic stiffness values makes it possible to differentiate various types of hyperkeratosis in proliferative verrucous leukoplakia lesions, such as orthohyperkeratosis and corrugated keratosis. Quantification of the dimensionless nonlinear elastic parameter β additionally enables differentiation of the keratin layer from the epithelial layer in proliferative verrucous leukoplakia lesions with corrugated keratosis. The first reported results obtained for excised tissue samples substantiate the prospects of C-OCE for the realization of new clinical tools for non-invasive diagnosis of oral pathologies.

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Compression optical coherence elastography as a new tool for non-invasive identification of precancerous lesions of the oral mucosa

Plekhanov,

Gazhva,

Ibragimova

et al. 2024

Laser Phys. Lett.

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Enhancing Oral Cancer Detection: A Systematic Review of the Diagnostic Accuracy and Future Integration of Optical Coherence Tomography with Artificial Intelligence

Jerjes,

Stevenson,

Ramsay

et al. 2024

JCM

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Introduction: Optical Coherence Tomography (OCT) has emerged as an important imaging modality in non-invasive diagnosis for oral cancer and can provide real-time visualisation of tissue morphology with the required high resolution. This systematic review aims to assess the diagnostic accuracy of OCT in the detection of oral cancers, and to explore the potential integration of OCT with artificial intelligence (AI) and other imaging techniques to enhance diagnostic precision and clinical outcomes in oral healthcare. Methods: A systematic literature search was conducted across PubMed, Embase, Scopus, Google Scholar, Cochrane Central Register, and Web of Science from inception until August 2024. Studies were included if they employed OCT for oral cancer detection, reported diagnostic outcomes, such as sensitivity and specificity, and were conducted on human subjects. Data extraction and quality assessment were performed independently by two reviewers. The synthesis highlights advancements in OCT technology, including AI-enhanced interpretations. Results: A total of 9 studies met the inclusion criteria, encompassing a total of 860 events (cancer detections). The studies spanned from 2008 to 2022 and utilised various OCT techniques, including clinician-based, algorithm-based, and AI-driven interpretations. The findings indicate OCT’s high diagnostic accuracy, with sensitivity ranging from 75% to 100% and specificity from 71% to 100%. AI-augmented OCT interpretations demonstrated the highest accuracy, emphasising OCT’s potential in early cancer detection and precision in guiding surgical interventions. Conclusions: OCT could play a very prominent role as a new diagnostic tool for oral cancer, with very high sensitivity and specificity. Future research pointed towards integrating OCT with other imaging methods and AI systems in providing better accuracy of diagnoses, plus more clinical usability. Further development and validation with large-scale multicentre trials is imperative for the realisation of this potential in changing the way we practice oral healthcare.

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Diagnostic value of optical coherence tomography for oral leukoplakia assessment

Cited by 2 publications

References 3 publications

Compression optical coherence elastography as a new tool for non-invasive identification of precancerous lesions of the oral mucosa

Compression optical coherence elastography as a new tool for non-invasive identification of precancerous lesions of the oral mucosa

Enhancing Oral Cancer Detection: A Systematic Review of the Diagnostic Accuracy and Future Integration of Optical Coherence Tomography with Artificial Intelligence

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