Diagnostic Value of Peripheral Fractional Flow Reserve in Isolated Iliac Artery Stenosis: A Comparison With the Post-Exercise Ankle-Brachial Index

Hioki, Hirofumi; Miyashita, Yusuke; Miura, Takashi; Ebisawa, Souichirou; Motoki, Hirohiko; Izawa, Atsushi; Tomita, Takeshi; Koyama, Jun; Ikeda, Uichi

doi:10.1583/14-4734mr.1

Cited by 19 publications

(19 citation statements)

References 22 publications

(19 reference statements)

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“…The cut-off of mean resting gradient to determine whether or not the stenosis is significant is discussed ranging from 5 ( 34 ) to 10 mm Hg ( 35 ). The peripheral fractional flow reserve (p-FFR), which is defined as the ratio of the mean pressure distal to the stenosis to the mean aortic pressure at hyperemia, could also be a valuable test ( 36 – 38 ).…”

Section: Strategies and Evidencesmentioning

confidence: 99%

Internal Iliac Artery Stenosis: Diagnosis and How to Manage it in 2015

Kaladji

Faucheur

Jaquinandi³

2015

Front. Cardiovasc. Med.

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Lower extremity arterial disease (LEAD) is a highly prevalent disease affecting 202 million people worldwide. Internal iliac artery stenosis (IIAS) is one of the localization of LEAD. This diagnosis is often neglected when a patient has a proximal walking pain since most physicians evoke a pseudoclaudication. Surprisingly, IIAS management is reported neither in the Trans-Atlantic Inter-Society Consensus II nor in the report of the American College Foundation/American Heart Association guidelines. The aims of this review are to present the current knowledge about the disease, how should it be managed in 2015 and what are the future research trends.

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Section: Strategies and Evidencesmentioning

confidence: 99%

Internal Iliac Artery Stenosis: Diagnosis and How to Manage it in 2015

Kaladji

Faucheur

Jaquinandi³

2015

Front. Cardiovasc. Med.

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“…Subsequently, Hioki et al conducted a prospective study to evaluate the clinical utility of PFFR in patients with isolated iliac artery stenosis and correlated this finding with the post-exercise ABI [9]. A total of 16 patients were included in this study.…”

Section: Reviewmentioning

confidence: 99%

The Use of Fractional Flow Reserve for Physiological Assessment of Indeterminate Lesions in Peripheral Artery Disease

Mangi

Kahloon

Elzanaty

et al. 2019

Cureus

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Peripheral artery disease (PAD) is a prevalent disorder in the United States, associated with significant morbidity and mortality. Fractional Flow Reserve (FFR) is a physiological test used to assess the hemodynamic significance of intermediate lesions on conventional angiography. It is well studied in coronary artery disease and is as an important tool to guide decisions regarding revascularization in a significant percentage of patients with intermediate lesions. As compared to coronary FFR, the use of FFR in peripheral artery disease (PFFR) is much less prevalent. Overall data regarding the use of the PFFR is sparse. There are limited studies that have shown the correlation of PFFR with non-invasive testing including ankle-brachial index (ABI) and Doppler Imaging. Unlike coronary FFR, the optimal pharmaceutical agents and doses to induce maximal hyperemia in the peripheral vascular bed are also not well established. Moreover, there are no established standardized procedural protocols for measuring PFFR. Various studies have employed varying techniques, hyperemic agents and doses. The aim of this literature review is to summarize the current evidence on PFFR, the correlation with noninvasive studies used in PAD and to increase awareness of the potential role of the PFFR in peripheral interventions.

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“…Another potential solution of problem is the use of peripheral FFR in intermediate stenosis. Hioki et al [ 82 ] found a good correlation of significant strength ( r = 0.857, p < 0.001) between intravascular peripheral FFR with papaverine and postexercise ABI. The correlation between the peak-to-peak pressure gradient in hyperemia and postexercise ABI was also significant, but of relatively milder strength ( r = −0.626, p = 0.013).…”

Section: Functional Assessment Of Intermediate Peripheral Vascularmentioning

confidence: 99%

Functional Assessment of Intermediate Vascular Disease

Yaneva-Sirakova

Serbezova

Vassilev

2018

BioMed Research International

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Interventional treatment in various vascular beds has advanced tremendously. However, there are several problems to be considered. We searched the literature and tried to analyze major parts of it. One is safety and applicability of coronary proven methods in other vascular beds. An unresolved problem is the functional assessment of intermediate lesions, as far as various target organs have quite different circulation from the coronary one and the functional tests should be modified in order to be applicable and meaningful. In the majority of the acute vascular syndromes, the culprit lesion is of intermediate size on visual assessment. On the other hand, a procedurally successfully managed high-degree stenosis is not always followed by clinical and prognostic benefit. In vascular beds, where collateral network naturally exists, the readings from the functional assessment are complicated and thus the decision for interventional treatment is even more difficult. Here come into help the functional assessment and imaging with IVUS, OCT, high-resolution MRI, and contrast enhanced CT or SPECT. The focus of the current review is on the functional assessment of intermediate stenosis in other vascular beds, unlike the coronary arteries.

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Diagnostic Value of Peripheral Fractional Flow Reserve in Isolated Iliac Artery Stenosis: A Comparison With the Post-Exercise Ankle-Brachial Index

Cited by 19 publications

References 22 publications

Internal Iliac Artery Stenosis: Diagnosis and How to Manage it in 2015

Internal Iliac Artery Stenosis: Diagnosis and How to Manage it in 2015

The Use of Fractional Flow Reserve for Physiological Assessment of Indeterminate Lesions in Peripheral Artery Disease

Functional Assessment of Intermediate Vascular Disease

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