Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Tursun, Serkan; Alpcan, Ayşegül; Özsoy, Metin; Badem, Nermin Dindar; Kandur, Yaşar; Acar, Banu

doi:10.1055/s-0041-1724024

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…It was previously demonstrated that in pediatric patients diagnosed with acute febrile UTIs, plasma sTREM-1 levels were higher compared to healthy controls. Additionally, it was reported that sTREM-1 exhibited diagnostic performance with a sensitivity of 57% and a specificity of 50% [25]. In a study conducted by Sierra-Diaz et al, differences in TREM-1 expression in children with and without UTIs were investigated through flow cytometry.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

Özsoy,

Ataman,

Şahin

et al. 2024

Diagnostics

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Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a new biomarker that can be used for the diagnosis and monitoring of urinary system infections. This study aimed to evaluate the diagnostic performance of serum sTREM-1 in patients with a diagnosis of acute stone pyelonephritis (ASP). This prospective study included 46 patients with a diagnosis of ASP and a control group of 23 individuals without urinary system infection. Blood samples were taken from participants upon hospital admission, and basal serum sTREM-1 levels were analyzed using the ELISA method. Serum sTREM-1 concentrations were measured after treatment of ASP patients. Basal leukocyte counts, C-reactive protein (CRP) levels, procalcitonin (PCT), and sTREM-1 (98.6 vs. 68.4 pg/mL, p < 0.001) levels were higher in the ASP group compared to the control group. After treatment, the median leukocyte counts, PCT, and sTREM-1 levels decreased and were similar to those of the control group. The median CRP level also decreased after treatment, but it remained higher than that of the control group. In predicting patients with ASP, the baseline sTREM-1 exhibited a sensitivity of 74.6% and a specificity of 78.2%, while its diagnostic performance was lower than that of leukocyte counts, CRP, and PCT. Despite the findings that levels of sTREM-1 were higher upon hospital admission in patients with ASP and significantly decreased after treatment, the utility of sTREM-1 as a biomarker for predicting patients with ASP remains constrained when compared to established inflammatory markers.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

Özsoy,

Ataman,

Şahin

et al. 2024

Diagnostics

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“…44 In a recent comparative study, 30 children with culture-positive febrile UTI and 30 healthy controls were investigated for the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a novel biomarker for childhood UTI. 45 sTREM-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI. TREM-1 is a protein surface receptor that amplifies toll-like receptorinduced inflammation by increased production of proinflammatory cytokines.…”

Section: More Recent Novel Biomarkers In Urinary Tract Infection Diag...mentioning

confidence: 97%

Are Positive Urine Cultures Directly Correlated with Elevated Levels of Novel Biomarkers for Childhood Urinary Tract Infection?

Uwaezuoke

Odimegwu

Chikani

et al. 2022

EMJ Microbiol Infect Dis

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Urinary tract infection (UTI) in children is one of the most common bacterial infections that propels inappropriate antibiotic use. Long-term, potentially fatal complications can occur if not properly treated. Prompt investigation and appropriate treatment would prevent these complications. Although urine culture remains the gold standard investigation for UTI, its process is cumbersome and requires time (24–72 hours). Hence, there has been growing interest in the use of urinary biomarkers. However, some conventional urinary biomarkers detected on urinalysis have poor sensitivity values when used singly as a screening tool. Thus, the searchlight has shifted to the role of novel biomarkers in UTI diagnosis. This narrative review aimed to determine if elevated levels of these biomarkers directly correlate with positive urine cultures. A positive correlation may imply that these biomarkers could serve as novel UTI diagnostics and thus augment urine culture requests. Established and recent serum and urinary biomarkers show disparate predictive abilities for UTI and its related complications. Some have elevated differential levels in upper and lower UTI or febrile and non-febrile UTI. All studies that investigated these biomarkers established culture-positive UTI, highlighting a direct correlation between positive urine cultures and increased concentrations of the biomarkers in body fluids. Because certain uropathogens were less likely to be associated with pyuria, the sensitivities of some neutrophil-related novel biomarkers (such as urine neutrophil gelatinase-associated lipocalin and human neutrophil peptides 1–3) were reduced in cases of UTI caused by these bacteria. While levels of these novel biomarkers directly correlate with positive urine cultures, it appears that there is yet no standalone biomarker with the optimal sensitivity and specificity for UTI. Although these novel biomarkers are promising, translating their measurements into clinical practice with specific clinical utilities will take time. Novel methods interrogating high-throughput serum (and urine) metabolome data with positive urine cultures in a platform-agnostic manner (metabolome-wide approach) will help confirm and identify novel biomarkers that might capture specific aetiologic agents or shared pathways of related agents. The authors recommend that future research on UTI diagnostics should specifically focus on identifying highly sensitive and specific standalone novel biomarkers that can be easily applied as a point-of-care investigation.

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“…At present, many reports have shown that amoxicillin and clavulanate potassium can reduce the clinical symptoms of UTI children, and especially oral administration of this drug can reduce the incidence of complications such as phlebitis, with definite efficacy [ 6 , 7 ]. However, UTI can recur in children due to factors such as immunocompromise, and recurrence is an important reason for the development of UTI into chronic renal failure [ 8 , 9 ]. However, amoxicillin and clavulanate potassium cannot improve the immune function of children, so it is extremely important to combine it with other therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Effect of Amoxicillin and Clavulanate Potassium Combined with Bazhengsan on Pediatric Urinary Tract Infection

Zhang

Wang

Xu³

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the therapeutic effect of amoxicillin and clavulanate potassium combined with Bazhengsan on pediatric urinary tract infection (UTI). Methods. The data of 120 UTI children treated in Wuhan Xinzhou District People’s Hospital from February 2019 to February 2020 were retrospectively analyzed. They were equally split into experimental group (EG) and control group (CG) according to the order of admission. All children were treated with amoxicillin and clavulanate potassium for suspension (twice a day), and EG was additionally treated with one dose of Bazhengsan daily. Both groups were treated for 10 days. After treatment, the immune function indexes, inflammatory factor levels, and clinical efficacy were compared before and after treatment. Results. No remarkable differences in the general data such as blood routine and urine routine results were observed between the two groups before treatment ( P > 0.05 ). After treatment, EG achieved obviously better immune function indexes ( P < 0.001 ) and lower levels of inflammatory factors ( P < 0.05 ) compared with CG. Besides, the treatment effective rate in EG (96.7%) was higher than that in CG ( P < 0.05 ). Conclusion. Amoxicillin and clavulanate potassium combined with Bazhengsan can improve the immune function of UTI children and reduce the levels of inflammatory factors, with remarkable effects, which should be popularized in practice.

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Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Cited by 3 publications

References 23 publications

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

Are Positive Urine Cultures Directly Correlated with Elevated Levels of Novel Biomarkers for Childhood Urinary Tract Infection?

Effect of Amoxicillin and Clavulanate Potassium Combined with Bazhengsan on Pediatric Urinary Tract Infection

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