Diagnostic value of recombinant heparin-binding hemagglutinin adhesin protein in spinal tuberculosis

Pu, Feifei; Feng, Jing; Niu, Fei; Xia, Ping

doi:10.1515/med-2020-0017

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Gonzalez‐Carrillo et al, 2016). Several studies indicated that both Ag85 complex encoded by fbpA/B/C and hbhA‐ encoding heparin‐binding haemagglutinin A (HBHA) are important adhesions of Mycobacteria (Pu et al, 2020; Viljoen et al, 2020), Lap protein encoded by lap is an adhesion molecule on the surface of Listeria (Jaradat & Bhunia, 2002), and the ibeA‐ encoding IbeA protein is an invasion of meningitic Escherichia coli (Damodara et al, 2008). However, except for gapA and mec gene family, the pathogenic effect of the predicted genes encoding adhesion and invasion in N. seriolae infection still need to be further verified.…”

Section: Discussionmentioning

confidence: 99%

Potential virulence factors of Nocardia seriolae AHLQ20‐01 based on whole‐genome analysis and its pathogenicity to largemouth bass (Micropterus salmoides)

Cao

Chang

Yue

et al. 2022

Journal of Fish Diseases

View full text Add to dashboard Cite

Nocardia spp., are Gram-positive, non-motile and aerobic actinomycetes, belonging to the family Nocardiaceae (Wang et al., 2017). In aquatic environments, four species of Nocardia have been isolated from diseased fish and shellfish, namely Nocardia asteroides, N. seriolae, N. salmonicida and N. crassostreae (Maekawa et al., 2018).Nocardia seriolae infection was initially reported from diseased yellowtail Seriola quinqueradiata and amberjack S. dumerili in Japan

show abstract

Section: Discussionmentioning

confidence: 99%

Potential virulence factors of Nocardia seriolae AHLQ20‐01 based on whole‐genome analysis and its pathogenicity to largemouth bass (Micropterus salmoides)

Cao

Chang

Yue

et al. 2022

Journal of Fish Diseases

View full text Add to dashboard Cite

show abstract

“…Heparin-binding haemagglutinin adhesin (HBHA), a surface-exposed TB protein, is one of the adhesins of M. tb, whose expression can be used as an indicator for PTB [146]. More so, HBHA has been reported to induce overproduction of IFN-γ in latent TB patients [147,148].…”

Section: Blood-associated Tb Biomarkersmentioning

confidence: 99%

Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

et al. 2021

View full text Add to dashboard Cite

The transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB diagnostic approaches, such as the culture, sputum smear, skin tuberculin, and molecular tests are time-consuming, and some are unaffordable for low-income countries. Rapid tests for disease biomarker detection are mostly based on immunological assays that use antibodies which are costly to produce, have low sensitivity and stability. Aptamers can replace antibodies in these diagnostic tests for the development of new rapid tests that are more cost effective; more stable at high temperatures and therefore have a better shelf life; do not have batch-to-batch variations, and thus more consistently bind to a specific target with similar or higher specificity and selectivity and are therefore more reliable. Advancements in TB research, in particular the application of proteomics to identify TB specific biomarkers, led to the identification of a number of biomarker proteins, that can be used to develop aptamer-based diagnostic assays able to screen individuals at the point-of-care (POC) more efficiently in resource-limited settings.

show abstract

Combined clinical significance of MRI and serum mannose-binding lectin in the prediction of spinal tuberculosis

Qi,

Luo,

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

Background Spinal tuberculosis (STB) is a local manifestation of systemic infection caused by Mycobacterium tuberculosis, accounting for a significant proportion of joint tuberculosis cases. This study aimed to explore the diagnostic value of MRI combined with mannose-binding lectin (MBL) for STB. Methods 124 patients suspected of having STB were collected and divided into STB and non-STB groups according to their pathological diagnosis. Serum MBL levels were measured using ELISA and a Pearson analysis was constructed to determine the correlation between MBL and STB. ROC was plotted to analyze their diagnostic value for STB. All the subjects included in the study underwent an MRI. Results The sensitivity of MRI for the diagnosis of STB was 84.38% and specificity was 86.67%. The serum MBL levels of the patients in the STB group were significantly lower than the levels in the non-STB group. ROC analysis results indicated that serum MBL’s area under the curve (AUC) for diagnosis of STB was 0.836, with a sensitivity of 82.3% and a specificity was 77.4%. The sensitivity of MRI combined with MBL diagnosis was 96.61%, and the specificity was 92.31%, indicating that combining the two diagnostic methods was more effective than using either one alone. Conclusions Both MRI and MBL had certain diagnostic values for STB, but their combined use resulted in a diagnostic accuracy than either one alone.

show abstract

Diagnostic value of recombinant heparin-binding hemagglutinin adhesin protein in spinal tuberculosis

Abstract: AbstractBackground and aimTo explore the diagnostic value of recombinant heparin-binding hemagglutinin adhesin (HBHA) protein antigen in spinal tuberculosis.Materials and methodsForty patients with spinal tuberculosis were included in the experimental group and 40 healt… Show more

Cited by 3 publications

References 16 publications

Potential virulence factors of Nocardia seriolae AHLQ20‐01 based on whole‐genome analysis and its pathogenicity to largemouth bass (Micropterus salmoides)

Potential virulence factors of Nocardia seriolae AHLQ20‐01 based on whole‐genome analysis and its pathogenicity to largemouth bass (Micropterus salmoides)

Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

Combined clinical significance of MRI and serum mannose-binding lectin in the prediction of spinal tuberculosis

Contact Info

Product

Resources

About