Diagnostic value of serum signal peptide-CUB-EGF-like domain-containing protein 1 levels in patients with acute appendicitis

Abstract

SUMMARY OBJECTIVE: Acute appendicitis is one of the most common surgical causes of an acute abdomen among patients admitted to the emergency room due to abdominal pain. The clinical diagnosis of acute appendicitis is usually difficult and is made by evaluating the clinical, laboratory, and radiological findings together. The aim of this study was to investigate the diagnostic potential of signal peptide-CUB-EGF-like domain-containing protein 1 as a biomarker for acute appendicitis. METHODS: A total of 67 adult patients without any comorbidities who presented to the emergency department with abdominal pain and were clinically diagnosed with acute appendicitis were included in the case group. The patients included in the study were classified into the negative appendectomy group and the acute appendicitis group according to their histopathological final diagnosis. In addition, 48 healthy volunteers without comorbidities were included in the control group. Signal peptide-CUB-EGF-like domain-containing protein 1 levels of patients and the control group were measured. RESULTS: According to postoperative histopathological examinations of the patients, 7 (10.4%) patients were diagnosed with negative appendectomy, and 60 (89.6%) patients were diagnosed with acute appendicitis. Signal peptide-CUB-EGF-like domain-containing protein 1 levels were higher in the patients with acute appendicitis than in negative appendectomy patients (p=0.012). Signal peptide-CUB-EGF-like domain-containing protein 1 levels were also higher in the case group compared to the control group (p=0.001). CONCLUSION: The admission signal peptide-CUB-EGF-like domain-containing protein 1 level was significantly higher in adults with acute appendicitis. The SCUBE1 level is a novel but promising biomarker that aids in the diagnosis of acute appendicitis.

The effect of inflammatory cytokines on the risk of hypertrophic scar: A Mendelian Randomization Study

“…CDCP1, a substrate of Src family kinases, plays a role in regulating resistance to cell death when detached from the extracellular matrix (anoikis), cell migration, and breakdown of the extracellular matrix during the invasion and spread of tumors, speci cally through tyrosine phosphorylation(Uekita & Sakai, 2011). Elevated levels of signal peptide-CUB-EGF-like domain-containing protein 1 (SCUBE1) were observed in adults diagnosed with acute appendicitis, indicating its potential as a novel and promising biomarker for predicting in ammation (Altuntas et al, 2023). In another study (Tokime et al, 2008), neurotrophic factors such as nerve growth factor and GDNF were suggested to be involved in the mechanism underlying the overgrowth and hypersensitivity of sensory nerves in atopic dermatitis (Huang et al, 2020).…”