Diagnostic Value of Simultaneous Determination of Pleural Adenosine Deaminase and Pleural Lysozyme/Serum Lysozyme Ratio in Pleural Effusions

Bueso, J. Fontan; Hernando, H. Verea; García-Buela, Jesús; Juncal, L. Dominguez; Egaña, Miguel; Martínez, Manuela

doi:10.1378/chest.93.2.303

Cited by 75 publications

(25 citation statements)

References 19 publications

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“…ADA [16, 17]is an enzyme needed for conversion of adenosine into inosine, which is fundamental in lymphocyte differentiation. ADA values [18, 19, 20]represent local activity of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Relevance of Adenosine Deaminase and Lysozyme Measurements in the Diagnosis of Tuberculous Pericarditis

et al. 2000

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Objective: To assess the value of pericardial fluid adenosine deaminase (ADA) and pericardial lysozyme (Lys) as tools in diagnosing tuberculous pericarditis. Methods: Forty-one patients (age range 17–77 years) with significant pericardial effusion were included in the study. Diagnostic pericardiocentesis and pericardial biopsy were performed while serum and pericardial fluid ADA and Lys were measured in all patients. Grouping of patients resulted as follows: group I = 7 patients with tuberculous pericarditis; group II = patients with neoplastic pericarditis; group III = 30 patients with idiopathic pericarditis. Results: Pairwise multiple comparison procedures revealed a significant difference of ADA in group I versus group III (p < 0.05) but not versus group II. Furthermore, pericardial Lys in group I was higher than in groups II and III (p < 0.05). A strong correlation between pericardial ADA and Lys was found (r = 0.733, p = 0.01) for all the patients. Receiver operating curves showed a value of 72 U/l as cutoff point of pericardium ADA, with a sensitivity of 100% and a specificity of 94% in the diagnosis of tuberculous pericarditis. Similarly for pericardial Lys, a value of 6.5 µg/dl had a sensitivity and specificity of 100 and 91.17%, respectively. Conclusions: Both measurements of pericardial ADA and Lys need to be taken into account when attempting the early diagnosis of tuberculous pericarditis.

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Section: Discussionmentioning

confidence: 99%

Relevance of Adenosine Deaminase and Lysozyme Measurements in the Diagnosis of Tuberculous Pericarditis

et al. 2000

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“…Some determinations from pleural fluid (mycobacterial DNA detected by PCR [6][7][8][9][10][11][12], interferon (IFN)-c [12][13][14][15][16][17], lysozyme [15,18,19] and adenosine deaminase (ADA) [2,12,15,[19][20][21][22][23][24]) can be useful in these diagnostic processes.…”

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Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions

Valdés

José²,

Dobaño³

et al. 2008

Eur Respir J

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“…In recent years, several biological parameters have been found to be diagnostic markers of tuberculous pleurisy [7][8][9][10][11][12]. Interferon-γ (IFN-γ) is a lymphokine produced by T-lymphocytes in response to antigen stimulation [13].…”

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Interferon-gamma in 388 immunocompromised and immunocompetent patients for diagnosing pleural tuberculosis

et al. 1996

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The level of interferon-gamma (IFN-gamma) in pleural fluid has been reported to be increased in pleural tuberculosis. Nevertheless, its diagnostic value has not yet been well-established, and immunocompromised patients have not previously been evaluated. The aim of this study was to determine the value of the IFN-gamma level in pleural fluid for diagnosing tuberculous pleurisy in immunocompetent and immunocompromised patients. Three hundred and eighty eight consecutive patients were studied prospectively (73 with tuberculous pleural effusions, including nine with concurrent human immunodeficiency virus (HIV) infection and one after liver transplantation, and 315 with nontuberculous effusions). IFN-gamma was measured by radioimmunoassay. The sensitivity of the test, using a 3.7 U.mL-1 cut-off point, was 0.99 (95% confidence interval (95% CI) 0.93-1.00) and the specificity was 0.98 (95% CI 0.96-1.00). The sensitivity of the test did not differ in HIV-positive and HIV-negative patients. Patients with lymphoma, vasculitis or vascular connective tissue disease did not have abnormal IFN-gamma values. In conclusion, the level of interferon-gamma in pleural fluid is a very good diagnostic marker of tuberculous pleural effusion, even in immunocompromised patients.

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Diagnostic Value of Simultaneous Determination of Pleural Adenosine Deaminase and Pleural Lysozyme/Serum Lysozyme Ratio in Pleural Effusions

Cited by 75 publications

References 19 publications

Relevance of Adenosine Deaminase and Lysozyme Measurements in the Diagnosis of Tuberculous Pericarditis

Relevance of Adenosine Deaminase and Lysozyme Measurements in the Diagnosis of Tuberculous Pericarditis

Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions

Interferon-gamma in 388 immunocompromised and immunocompetent patients for diagnosing pleural tuberculosis

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