Diagnostic value of six MRI features for central neurocytoma

Abstract

• This study is the largest magnetic resonance imaging (MRI) cohort on central neurocytoma (CN). • Three new features helpful for the diagnosis of CN were reported. • Diagnostic value of six MRI features of CN was preliminarily determined.

Central neurocytoma—positive and differential diagnosis: An example through a case report

“…The “scalloping sign,” considered as a combination of ventricular wall undulations and spicules of peripheral cysts, was the most specific sign and is better depicted on sagittal views. 14 , 15 The “broad-based attachment” is another imaging feature with the highest sensitivity. It is related to the origin of this intraventricular tumor, which is explained by its derivation from the small gray nuclei of the septum pellucidum or the bipotential progenitor cells on the periventricular matrix.…”

“…In CN, this rule is broken, and peripheral cysts are of excellent specificity to raise the diagnosis with no pathological basis to date to explain this sign. 14 The other particularity of CN’s cysts is a “fluid–fluid level” appearance which is the consequence of bleeding, an infrequent event in CN, thus, less sensitive.…”

A rare case of intraventricular gangliocytoma

“…Histopathologic ( Figure 2 ) and immunohistochemical ( Figure 3 ) analysis revealed the diagnosis of gangliocytoma. Gangliocytomas are rare low-grade central nervous system tumors composed of dysplastic ganglion cells, usually presenting in children or young adults and located in the cerebral hemispheres 1 , 2 . Until now, there are no case reports of intraventricular gangliocytoma.…”

Noninvasive Assessment of O(6)‐Methylguanine‐DNA Methyltransferase Promoter Methylation Status in World Health Organization Grade II–IV Glioma Using Histogram Analysis of Inflow‐Based Vascular‐Space‐Occupancy Combined with Structural Magnetic Resonance Imaging

“…[6][7][8][9] However, the determination of structural imaging features is prone to subjective bias. 10 Using advanced, quantitative MRI techniques such as diffusion weighted imaging (DWI), diffusion tensor imaging, and amide proton transfer (APT) imaging, some studies demonstrated that MGMT methylated gliomas were likely to show higher apparent diffusion coefficient (ADC) values, lower fractional anisotropy values, and lower APT-weighted signal. 9,11,12 However, these results were not replicated in other studies with larger sample size.…”

“…Some structural MRI features, such as the lobes involved, location of contrast‐enhancing lesion, and enhancement patterns, have been reported to correlate with glioma MGMT methylation status 6–9 . However, the determination of structural imaging features is prone to subjective bias 10 …”