Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in malignant pleural effusion in patients with lung cancer

Xu, Chunhua; Hao, Ke-Ke; Yu, Li; Zhang, Xiuwei

doi:10.1111/ajco.12195

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…In addition, Xu et al . demonstrated that from the 60 malignant PE patients studied, 54 had CEA >5.5 ng/mL . The same team showed that combined detection of IL‐17 and CEA has sensitivity and specificity values of 96.4% and 92.3% in distinguishing malignant from benign PEs .…”

Section: Discussionmentioning

confidence: 91%

“…The tumor group of our study population comprised patients with lung cancer as the largest subgroup of patients. Interestingly, several studies have recently indicated the value of CEA in the diagnosis and prognosis of lung cancer with PEs, among other biomarkers . Indeed, high serum CRP and CEA levels were identified as independent prognostic indicators for the survival of patients with stage III–IV non‐small cell lung cancer (NSCLC) .…”

Section: Discussionmentioning

confidence: 99%

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Pleural fluid carcinoembryonic antigen as a biomarker for the discrimination of tumor‐related pleural effusion

Huang

Tang

et al. 2016

Clinical Respiratory J

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We read with interest the article by Li et al. (accepted article in Clin Respir J) on pleural fluid carcinoembry-onic antigen (CEA) as a biomarker for the discrimination of tumor-related pleural effusion (1). We would like to ask three points. First, the authors described that a diagnosis of probable tumor pleural effusion was made in patients with a known primary malignancy showing negative pleural fluid cytology results, after ruling out benign causes of pleural fluid. We agree with the method, but what is the number of the lung cancer patients with negative malignant cells in pleural fluid in this study. Second, recommended CEA level in pleural fluid would be changed if the ratio of patients with adenocarcinoma and those with non-adenocarcinoma are changed. We do wonder whether the authors determine the CEA cutoff level in pleural fluid taking the ratio into the consideration. How the authors evaluate the relationship between the ratio of types of lung cancer (adenocarcinoma and non-adeno-carcinoma) and the cutoff CEA level. Third, the authors showed that they used Roche's CEA kit in this study. This may be CEA kit for serum/plasma CEA measurement. We would like to ask how much cutoff serum/plasma CEA level was. Was the cutoff level of CEA different from that the authors recommend cutoff CEA level in pleural fluid? We do appreciate hearing from the authors why cutoff CEA level in pleural fluid are different from cutoff CEA level in serum/plasma.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Pleural fluid carcinoembryonic antigen as a biomarker for the discrimination of tumor‐related pleural effusion

Huang

Tang

et al. 2016

Clinical Respiratory J

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“…These studies showed that lung cancers expressing RCAS1 may be progressive and invasive, indicating that tissue RCAS1 expression can be considered as an informative biomarker in the management of lung cancer. However, the clinical application of circulating RCAS1 concentrations in pleural fluid and serum as a marker in the diagnosis and management of malignancies needs to be further explored, since the data so far are still limited [15,[21][22][23]. Aoe et al found that the RCAS1 concentrations in MPE were significantly higher than those in non-malignant pleural fluid [15,22].…”

Section: Discussionmentioning

confidence: 99%

“…Xu et al reported that RCAS1 had a sensitivity of 83.3 % and a specificity of 91.4 % for the diagnosis of MPE at the cutoff point of 9.7 U/mL, suggesting that RCAS1 should be an informative tumor marker for the differential diagnosis of MPE and benign pleural effusion [21]. However, there was a significant correlation between the concentrations of RCAS1 and CEA, limiting the utility of combination detection of the two indices.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in differentiating malignant from benign pleural effusion

2015

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Diagnosis of malignant pleural effusion (MPE) remains a major clinical challenge. The aim of this study was to evaluate the diagnostic value of combined detection of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and carcinoembryonic antigen (CEA) in patients with MPE and benign pleural effusion (BPE). The serum and pleural fluid samples were collected from 53 patients diagnosed with MPE and 49 patients with BPE. Enzyme-linked immunosorbent assay was used to detect the concentration of RCAS1 in serum and pleural effusion. The clinical data and laboratory information, including CEA levels, were gathered from these cases. The concentration of RCAS1 in MPE was significantly higher than that of BPE (P < 0.001). There was no significant difference between the two serum groups. The diagnostic sensitivity and specificity of pleural fluid RCAS1 were 67.92 and 81.63 %, respectively, at the optimized cutoff value of 7.326 U/mL; meanwhile, the sensitivity and specificity of pleural fluid CEA were 83.02 and 91.84 % at the cutoff value of 3.93 ng/mL. The specificity could be elevated to 98.50 % in serial detection, while the sensitivity may be improved to 94.55 % in parallel detection. Serum RCAS1 concentration was only detected in 53 serum samples out of the 102 samples, indicating that serum RCAS1 may not be a better option in differential diagnosis of malignancies compared with serum CEA, of which the diagnostic sensitivity and specificity were 64.15 and 83.67 % at the cutoff value of 3.90 ng/mL. No significant differences were found in pleural fluid RCAS1 concentration in MPE patients with different ages, gender, and pathological types of lung cancers. The detection of RCAS1 concentration in pleural fluid is informative for the diagnosis of MPE. Joint detection of RCAS1 and CEA can improve the diagnostic sensitivity and specificity. However, the diagnostic value of RCAS1 is not higher than that of CEA.

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“…They found that a level of Ca-125 above 1000 U/ml in combination with fragments of cytokeratin 19 -CYFRA 21-1 of >100 ng/ml was significantly associated with lower survival (Bielsa et al, 2009). Xu et al (2015) determined the level of CEA in 60 malignant and 58 benign pleural fluids and established that in 54 patients with malignant pleural effusion the level of CEA was >5.5 ng/ml and at this cut-off value the combination of CEA with tumour marker Type II membran protein RCAS yielded sensitivity of 98.3 and specificity of 91.4% (Xu et al, 2015); according to our data, at a cut-off value of 6.58 ng/ml the sensitivity of CEA was 58.2% and specificity 92.4%. Son et al (2015) analysed 47 benign and 52 malignant pleural effusions and compared the diagnostic values of tumour markers CD66c, CEA, Ca 19-9, and CYFRA 21-1 in pleural puncture fluid.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

Žentiņa

Stukena

Grīnberga

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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The significance of carbohydrate (cancer) antigen 125 and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ³ 1452 U/mL and 76.9% at cut-off value ³ 6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions.

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Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in malignant pleural effusion in patients with lung cancer

Abstract: The combined detection of sRCAS1 and CEA may be more valuable in the differential diagnosis between MPE and BPE.

Cited by 5 publications

References 25 publications

Pleural fluid carcinoembryonic antigen as a biomarker for the discrimination of tumor‐related pleural effusion

Pleural fluid carcinoembryonic antigen as a biomarker for the discrimination of tumor‐related pleural effusion

Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in differentiating malignant from benign pleural effusion

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

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