Diagnostic value of STAF score in combination with D-dimer in cardioembolism

Liu, Libin; Guo, Yadong; Xu, Anding; Zhong, Jie-Xi; Zhuo, Wen-Yan

doi:10.1371/journal.pone.0204838

Cited by 3 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 Some studies reported elevated D-dimer values were more predictive of cardiogenic stroke when combining with B-type natriuretic peptide and a clinical predictive score for occult AF in stroke patients. 8,32 Prediction of recurrent stroke D-dimer measurement may be useful for evaluating the risk of recurrent stroke in cryptogenic stroke. Previous studies showed that D-dimer levels in full cohorts including all etiologies with acute ischemic stroke were not predictive of long-term recurrent stroke.…”

Section: Cryptogenic Stroke/embolic Stroke Of Undetermined Source Etimentioning

confidence: 99%

The emerging value of serum D-dimer measurement in the work-up and management of ischemic stroke

Ohara

Farhoudi

Bang

et al. 2019

International Journal of Stroke

View full text Add to dashboard Cite

Background Elevated D-dimer levels are a marker of both thrombin formation and fibrinolysis. Currently D-dimer measurement is routinely used for ruling out venous thromboembolism and diagnosis/monitoring of disseminated intravascular coagulation. Recent emerging data suggest that D-dimer may become an important biomarker in ischemic stroke as well as in cardiovascular diseases. Aims To outline the clinical utility of D-dimer in work-up and management of ischemic stroke. Summary D-dimer measurement is most useful in stroke with active cancer as it can confirm etiologic diagnosis, predict recurrent stroke risk, and aid treatment decision in cancer-associated stroke. In cryptogenic stroke, high D-dimer levels can also provide clues for the cause of stroke as occult cancer and undetected cardiac embolic source as occult atrial fibrillation and may be helpful in treatment decision making of secondary stroke prevention. Serial D-dimer measurements should be further studied to monitor antithrombotic therapy effectiveness in both cardiogenic and cryptogenic etiologies. Conclusion Accumulating data suggests the utility of D-dimer test in the management of ischemic stroke, although the evidence is still limited. Future studies would clarify the role of D-dimer measurement in ischemic stroke.

show abstract

Section: Cryptogenic Stroke/embolic Stroke Of Undetermined Source Etimentioning

confidence: 99%

The emerging value of serum D-dimer measurement in the work-up and management of ischemic stroke

Ohara

Farhoudi

Bang

et al. 2019

International Journal of Stroke

View full text Add to dashboard Cite

show abstract

“…It has been confirmed [7] that STAF can be used to effectively diagnose atrial fibrillation in cerebral infarction cases and aid in tracking patients' condition progression following cerebral infarction, and a separate study demonstrated that STAF scores were notably higher in CE patients compared to NCE patients. Furthermore, STAF's diagnostic utility for CE patients surpassed that of cardiac troponin I, underscoring its value as a reliable reference for predicting CE diagnoses [17]. In this study, STAF was higher in patients from the CE group compared to those in the NCE group, demonstrating a clear association between STAF and the occurrence of CE in patients.…”

Section: F I G U R E 2 Roc Curves Of Right Heart Contrast Echocardiog...mentioning

confidence: 57%

Predictive value of right heart contrast echocardiography combined with STAF in cardioembolism

2024

View full text Add to dashboard Cite

Cardioembolism (CE) is a prevalent cerebrovascular disease in clinical practice. This study aims to assess the predictive efficacy of right heart contrast echocardiography combined with the Score for Targeting Atrial Fibrillation (STAF) for diagnosing CE. A total of 149 patients with CE and 93 patients with non-CE (NCE) were classified into the study group and control group, respectively, and their data were retrospectively analyzed. All patients underwent right heart contrast echocardiography and STAF assessment, and comparative analyses between the groups were performed. In addition, the predictive potential of combining right heart contrast echocardiography with STAF for CE was evaluated, and the CE patients underwent a one-year follow-up to assess survival and prognostic factors. The results of this study showed that patients in the CE group had higher incidences of grade 1 + 2 + 3 right-to-left shunt, patent foramen ovale (PFO) positivity, greater foramen ovale length, larger shunt inner diameter, and higher STAF score compared to the NCE group (p < 0.05). Receiver operating characteristic curve analysis revealed that the predictive values for CE, in terms of right-to-left shunt grade, PFO positivity, foramen ovale length, shunt inner diameter, and area under the curve (AUC) for STAF, were 0.582, 0.570, 0.679, 0.808 and 0.750, respectively. The combined AUC value for all these parameters was 0.905. Univariate and multiple logistic regression analysis indicated that atrial fibrillation, total cholesterol and fibrinogen were not prognostic factors in CE patients (p > 0.05), whereas National Institute of Health stroke scale (NIHSS) score, PFO positivity, foramen ovale length and STAF at admission were prognostic factors (p < 0.05). Therefore, combining right heart contrast echocardiography with STAF may enhance the predictive efficacy for CE.

show abstract

Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study

Ratajczak-Tretel¹,

Lambert²,

Al-Ani³

et al. 2023

J Neurol

View full text Add to dashboard Cite

Background Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study. Method The NOR-FIB study was an international prospective observational multicenter study designed to detect and quantify AF in CS and cryptogenic transient ischaemic attack (TIA) patients monitored by the insertable cardiac monitor (ICM), and to identify AF-predicting biomarkers. The utility of the following AF-predicting scores was tested: AS5F, Brown ESUS-AF, CHA2DS2-VASc, CHASE-LESS, HATCH, HAVOC, STAF and SURF. Results In univariate analyses increasing age, hypertension, left ventricle hypertrophy, dyslipidaemia, antiarrhythmic drugs usage, valvular heart disease, and neuroimaging findings of stroke due to intracranial vessel occlusions and previous ischemic lesions were associated with a higher likelihood of detected AF. In multivariate analysis, age was the only independent predictor of AF. All the AF-predicting scores showed significantly higher score levels for AF than non-AF patients. The STAF and the SURF scores provided the highest sensitivity and negative predictive values, while the AS5F and SURF reached an area under the receiver operating curve (AUC) > 0.7. Conclusion Clinical risk scores may guide a personalized evaluation approach in CS patients. Increasing awareness of the usage of available AF-predicting scores may optimize the arrhythmia detection pathway in stroke units.

show abstract

Diagnostic value of STAF score in combination with D-dimer in cardioembolism

Cited by 3 publications

References 33 publications

The emerging value of serum D-dimer measurement in the work-up and management of ischemic stroke

The emerging value of serum D-dimer measurement in the work-up and management of ischemic stroke

Predictive value of right heart contrast echocardiography combined with STAF in cardioembolism

Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study

Contact Info

Product

Resources

About