Diagnostic Value of Troponin T in Neonates of Mild Pre-Eclamptic Mothers

Narın, Nazmi; Çetin, Neşide; Kılıç, Harun; Başbuğ, Mustafa; Narin, Figen; Kafali, M.; Üzüm, Kazım; Genç, Ercan; Üstünbaş, Hasan Basri

doi:10.1159/000014089

Cited by 35 publications

(28 citation statements)

References 10 publications

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“…Such cTnT values were also obtained by Narin et al [28] who tested cTnT in 17 healthy full-term neonates selected as a control group to be compared with 15 neonates of preeclamptic mothers. cTnT was signifi cantly higher in the preeclamptic group (0.70 ng/ml) than in the control group.…”

Section: Discussionmentioning

confidence: 55%

Usefulness of Cardiac Troponin T and Echocardiography in the Diagnosis of Hypoxic Myocardial Injury of Full-Term Neonates

Szymankiewicz

Matuszczak-Wleklak²,

Hodgman³

et al. 2005

Neonatology

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Background: Perinatal asphyxia constitutes a significant problem influencing neonatal mortality and morbidity. Objectives: The aim of the present work was to provide evidence of the usefulness of cardiac troponin T (cTnT) and echocardiographic investigations in the diagnosis of heart damage in full-term infants after intrauterine hypoxia. Material and Methods: The subjects were 39 asphyxiated and 44 term infants without fetal anoxia. Quantitative determinations of cTnT were performed between 12 and 24 h of life. Two-dimensional Doppler and color Doppler studies were performed at the bedside. We evaluated fractional shortening (FS), cardiac output (CO), cardiac index (CI), tricuspid (TI) and mitral (MI) insufficiency. Results: Asphyxiated infants presented increased cTnT (mean 0.141 ± 0.226 vs. 0.087 ± 0.111ng/ml; p < 0.01) and TI (38.5 vs. 11.4% of population; p < 0.05) compared to healthy infants. CO, CI and FS remained in the same range. Conclusions: We found cTnT to be the most useful among accessible diagnostic tools used in post-hypoxic heart damage in neonates. The data from our relatively small population study suggest a cTnT value of >0.1 ng/ml as a reliable marker of myocardial injury in neonates. Further study should be performed to generate a receiver-operator characteristic curve to discover what the cut-off level should be.

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Section: Discussionmentioning

confidence: 55%

Usefulness of Cardiac Troponin T and Echocardiography in the Diagnosis of Hypoxic Myocardial Injury of Full-Term Neonates

Szymankiewicz

Matuszczak-Wleklak²,

Hodgman³

et al. 2005

Neonatology

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“…The serum TnT concentration in neonates of preeclamptic mothers (0.70 g/l) was significantly higher than controls (0.10 g/l) in a study of 32 infants [43] . Adamcova et al [44] showed a higher cTnT levels in infants following tocolysis (0.24 8 0.05 vs. 0.05 8 0.01 g/l).…”

Section: Influence Of Other Factors On Troponinmentioning

confidence: 70%

Serum Troponin in Neonatal Intensive Care

El-Khuffash

Molloy

2007

Neonatology

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Cardiac troponins have a major role in screening and diagnosis of myocardial ischaemia in adults and children. Their introduction has redefined the diagnosis of myocardial infarction in adults and provided valuable prognostic information. In the paediatric population, troponins show a good correlation with the extent of myocardial damage following cardiac surgery and cardiotoxic medication, and can be used as predictors of subsequent cardiac recovery and mortality. This review discusses the current established reference values in term and preterm infants and demonstrates their potential use in neonatology. They may serve as a useful adjunct in the assessment of the magnitude of myocardial injury in respiratory distress syndrome and asphyxia. They may also benefit centres without on-site echocardiography with some evidence showing good correlation with echo-derived markers of myocardial function. The use of troponins in the neonatal unit remains a research tool. More work is needed to explore their prognostic role and monitoring response to treatment following cardioprotective strategies. In preterm infants the effect of inotropes on myocardial function needs further study and troponin may form an integral part of this research.

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“…Neonates demonstrate higher cTnT following a preeclamptic pregnancy compared to a normal pregnancy [15] . There is evidence of cardiac dysfunction with a lower fetal atrial contraction and signifi cantly higher mean mitral peak velocity of early diastole to peak velocity of the atrial contraction (E/A) ratio.…”

Section: Cardiac Troponin Measurements In Neonatesmentioning

confidence: 88%