Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma

Fujima, Noriyuki; Kameda, Hiroyuki; Tsukahara, Akiko; Yoshida, Daisuke; Sakashita, Tetsuya; Homma, Akihiro; Tha, Khin Khin; Kudo, Kohsuke; Shirato, Hiroki

doi:10.1016/j.ejrad.2015.07.026

Cited by 21 publications

(11 citation statements)

References 20 publications

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“…Previous studies on NPC [16,18] applied ASL with PLD of 1025 ms, 1525 ms, and 2025 ms. The optimal selection of PLD is 1025 ms due to its best performance on evaluating perfusion and delineating the volume of NPC, which was also similar to previous studies on malignant tumors of nasal cavity and neck with PLD of 1280 ms [20,36].…”

Section: Discussionsupporting

confidence: 80%

“…Moreover, other studies showed BF could help delineating the tumor extent by the fusion image of the BF map with T2WI [18] and evaluating clinical stages with moderate positive correlations to T stage and AJCC stage [19]. For head and neck tumors, studies suggested that ASL could assist the diagnosis and differentiation of pathological types of tumors [20,21], monitor the effect of head and neck tumor before and after non-surgical treatment, and evaluate the potential existence of residual tumors [22].…”

Section: Discussionmentioning

confidence: 99%

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Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

et al. 2020

Cancer Imaging

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Background: To investigate the diagnostic value of arterial spin labeling (ASL) and intravoxel incoherent motion (IVIM) imaging in distinguishing nasopharyngeal carcinoma (NPC) in T1 stage from healthy controls (HC). Methods: Forty-five newly diagnosed NPC patients in the T1 stage and thirty-one healthy volunteers who underwent MR examinations for both 3D pseudo-continuous ASL (pCASL) and IVIM were enrolled in this study. The Mann-Whitney test was used to compare the mean values of blood flow (BF) derived from pCASL and IVIM derived parameters, including apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f) between NPC tumor and benign nasopharyngeal mucosa of HC. Receiver Operating Characteristic (ROC) was performed to determine diagnostic cutoff and efficiency. The correlation coefficients among parameters were investigated using Spearman's test. Results: The NPC in the T1 stage showed higher mean BF, lower ADC, D, and f compared to benign nasopharyngeal mucosa (P < 0.001) with the area under curve of ROC of 0.742-0.996 (highest by BF). BF cutoff was set at > 36 mL/100 g/min; the corresponding sensitivity, specificity, and accuracy in differentiating NPC stage T1 from benign nasopharyngeal mucosa were 95.56% (43/45), 100% (31/31) and 97.37% (74/76), respectively. BF demonstrated moderate negative correlation with D* on HC (ρ [Spearman correlation coefficients] = − 0.426, P = 0.017). Conclusions: ASL and IVIM could reflect the difference in perfusion and diffusion between tumor and benign nasopharyngeal mucosa, indicating a potential for accessing early diagnosis of NPC. Notably, BF, with a specificity of 100%, demonstrated better performance compared to IVIM in distinguishing malignant lesions from healthy tissue.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

et al. 2020

Cancer Imaging

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“…Magnetic resonance imaging (MRI) has been proven to play crucial roles in the differential diagnosis of sinonasal tumors [10,11], especially for classification of the lymphoma and squamous cell carcinoma [12][13][14]. Previous studies reported that the homogenous signal intensity, facial soft tissue involvement, and low ADC values on MR findings suggested the diagnosis of the lymphomas [12][13][14]. However, whether these features can help in differential diagnosis of lymphoma subtypes is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Differential diagnosis of sinonasal extranodal NK/T cell lymphoma and diffuse large B cell lymphoma on MRI

Chen

Wang

et al. 2020

Neuroradiology

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Purpose To evaluate whether imaging features on conventional magnetic resonance imaging (MRI) can differentiate sinonasal extranodal natural killer/T cell lymphomas (ENKTL) from diffuse large B cell lymphoma (DLBCL). Methods Consecutively, pathology-proven 59 patients with ENKTL and 27 patients with DLBCL in the sinonasal region were included in this study. Imaging features included tumor side, location, margin, pre-contrast T1 and T2 signal intensity and homogeneity, post-contrast enhancement degree and homogeneity, septal enhancement pattern, internal necrosis, mass effect, and adjacent involvements. These imaging features for each ENKTL or DLBCL on total 86 MRI scans were indicated independently by two experienced head and neck radiologists. The MRI-based performance in differential diagnosis of the two types of lymphomas was evaluated by multivariate logistic regression analysis. Results All ENKTLs were located in the nasal cavity, with ill-defined margin, heterogeneous signal intensity, internal necrosis, marked enhancement of solid component on MRI, whereas DLBCLs were more often located in the paranasal sinuses, with MR homogenous intensity, mild enhancement, septal enhancement pattern, and intracranial or orbital involvements (all P < 0.05). Using a combination of location, internal necrosis and septal enhancement pattern of the tumor in multivariate logistic regression analysis, sensitivity, specificity, and accuracy in differential diagnosis of ENKTL and DLBCL were 100%, 79.4%, and 91.9%, respectively, for radiologist 1, and were 98.3%, 81.5%, and 93.0%, respectively, for radiologist 2. Conclusion MRI can effectively differentiate ENKTL from DLBCL in the sinonasal region with a high diagnostic accuracy.

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“…The histogram parameter of relative mean signal value in each tumor was calculated as the mean value of the signal intensity in the tumor ROI, and by dividing the mean signal intensity of the outlined posterior neck muscle ROI. The histogram parameters of CV, kurtosis and skewness were calculated using the following equations [14]:…”

Section: Methodsmentioning

confidence: 99%

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies

et al. 2019

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BackgroundTo assess the utility of histogram and texture analysis of magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for the prediction of histological diagnosis of head and neck squamous cell carcinoma (SCC) and malignant lymphoma (ML).MethodsThe cases of 57 patients with SCC (45 well/moderately and 12 poorly differentiated SCC) and 10 patients with ML were retrospectively analyzed. Quantitative parameters with histogram features (relative mean signal, coefficient of variation, kurtosis and skewness) and gray-level co-occurrence matrix (GLCM) features (contrast, correlation, energy and homogeneity) were calculated using Fs-T2WI data with a manual tumor region of interest (ROI).ResultsThe following significantly different values were obtained for the total SCC versus ML groups: relative mean signal (3.65 ± 0.86 vs. 2.61 ± 0.49), contrast (72.9 ± 16.2 vs. 49.3 ± 8.7) and homogeneity (2.22 ± 0.25 × 10− 1 vs. 2.53 ± 0.12 × 10− 1). In the comparison of the SCC histological grades, the relative mean signal and contrast were significantly lower in the poorly differentiated SCC (2.89 ± 0.63, 56.2 ± 12.9) compared to the well/moderately SCC (3.85 ± 0.81, 77.5 ± 13.9). The homogeneity in poorly differentiated SCC (2.56 ± 0.15 × 10− 1) was higher than that of the well/moderately SCC (2.1 ± 0.18 × 10− 1).ConclusionsParameters obtained by histogram and texture analysis of Fs-T2WI may be useful for noninvasive prediction of histological type and grade in head and neck malignancy.

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Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma

Cited by 21 publications

References 20 publications

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

Differential diagnosis of sinonasal extranodal NK/T cell lymphoma and diffuse large B cell lymphoma on MRI

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies

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