Diagnostic value of tumoural markers in pleural effusions

Üstün, Hasan; Borazan, Ali; Bilgiçli, Nesrin; Yılmaz, Ahmet

doi:10.1111/j.1368-5031.2004.0015.x

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…Our study showing synergism between LPA and troglitazone also suggests that different ligands activating a common nuclear receptor may induce different effects, including different sets of genes and biological activities [1]. Future experiments to test the physiological effects of LPA generated by GPAT will require the use of mammalian cells that have both a high expression of PPARγ and a low activity of GPAT that can be enhanced by transfection.…”

Section: Discussionmentioning

confidence: 69%

“…Peroxisome proliferator activated receptor-γ (PPARγ) is a nuclear receptor that is highly expressed when pre-adipocytes differentiate into adipocytes [1]. PPARγ regulates gene expression by forming a heterodimer with the retinoid × receptor (RXR) and binding to PPAR response elements (PPRE) in the promoter region of target genes.…”

Section: Introductionmentioning

confidence: 99%

“…PPARγ regulates gene expression by forming a heterodimer with the retinoid × receptor (RXR) and binding to PPAR response elements (PPRE) in the promoter region of target genes. Genes that are regulated by PPARγ are primarily involved in adipocyte differentiation and fatty acid metabolism [1]. Ligands for PPARγ include polyunsaturated fatty acids [2] and synthetically derived thiazolidinedione (TZD) ligands for PPARγ that improve insulin sensitivity in patients with type 2 diabetes [1].…”

Section: Introductionmentioning

confidence: 99%

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Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

et al. 2011

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Lysophosphatidic acid (LPA) is an agonist for peroxisome proliferator activated receptor-γ (PPARγ). Although glycerol-3-phosphate acyltransferase-1 (GPAT1) esterifies glycerol-3-phosphate to form LPA, an intermediate in the de novo synthesis of glycerolipids, it has been assumed that LPA synthesized by this route does not have a signaling role. The availability of Chinese Hamster Ovary (CHO) cells that stably overexpress GPAT1, allowed us to analyze PPARγ activation in the presence of LPA produced as an intracellular intermediate. LPA levels in CHO-GPAT1 cells were 6-fold higher than in wild-type CHO cells, and the mRNA abundance of CD36, a PPARγ target, was 2-fold higher. Transactivation assays showed that PPARγ activity was higher in the cells that overexpressed GPAT1. PPARγ activity was enhanced further in CHO-GPAT1 cells treated with the PPARγ ligand troglitazone. Extracellular LPA, phosphatidic acid (PA) or a membrane-permeable diacylglycerol had no effect, showing that PPARγ had been activated by LPA generated intracellularly. Transient transfection of a vector expressing 1-acylglycerol-3-phosphate acyltransferase-2, which converts endogenous LPA to PA, markedly reduced PPARγ activity, as did over-expressing diacylglycerol kinase, which converts DAG to PA, indicating that PA could be a potent inhibitor of PPARγ. These data suggest that LPA synthesized via the glycerol-3-phosphate pathway can activate PPARγ and that intermediates of de novo glycerolipid synthesis regulate gene expression.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

et al. 2011

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“…However, combined with clinical and radiologic findings, the concentrations of tumour markers in serum or pleural fluid can be useful in determining the origin of a tumour 14 .…”

Section: Discussionmentioning

confidence: 99%

Pleural Fluid Tumour Markers in Malignant Pleural Effusion with Inconclusive Cytologic Results

et al. 2015

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“…However, CA 15-3 may also be elevated in some nonmalignant diseases such as chronic hepatitis, cirrhosis, sarcoidosis, TB, and systemic lupus erythematosus 15,16,24,25. A value greater than 25 U/mL is considered high.…”

Section: Discussionmentioning

confidence: 99%

The utility of tumor markers CA 125, CA 15-3, and CA 19-9 in assessing the response to therapy in pulmonary and pleural tuberculosis

Tasci¹,

Özkaya²,

Ozkara³

et al. 2012

OTT

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Aim:Both of the diagnosis and treatment evaluation are time-consuming conditions in patients with pulmonary and pleural tuberculosis. The aim of this study was to establish the validity of tumor markers CA 125, CA 15-3, and CA 19-9 in the diagnosis of pulmonary and pleural TB and to verify the success of the treatment protocol.Patients and methods:The levels of tumor markers CA 125, CA 15-3, and CA 19-9 were measured before and after treatment in 67 TB patients, 54 of whom had pulmonary TB and 13 of whom had pleural TB. All values were compared with the results of a healthy control group of 44 subjects.Results:CA 125 and CA 15-3 levels were significantly high when compared with those of the healthy control group and there was a significant decrease in both tumor marker levels after treatment in patients with pulmonary TB (P < 0.001 and P < 0.004, respectively). However, the difference found in CA 19-9 levels before and after treatment in patients with pulmonary TB was not statistically significant (P < 0.08). When the CA 125, CA 15-3, and CA 19-9 values of the pulmonary TB group before treatment were compared with that of the healthy control group, the results were statistically significant in all parameters except CA 19-9 (P < 0.001, P < 0.001, and P < 0.09 for CA 125, CA 15-3, and CA 19-9, respectively). In the patients with pleural TB, CA 125, CA 15-3, and CA 19-9 values did not change significantly after treatment.Conclusion:The authors suggest that CA 125 and CA 15-3 tumor markers may be important for verification of the success of treatment protocol in pulmonary TB, as the differences found for these tumor markers between the pre- and the posttreatment periods are statistically significant.

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Diagnostic value of tumoural markers in pleural effusions

Cited by 16 publications

References 25 publications

Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

Pleural Fluid Tumour Markers in Malignant Pleural Effusion with Inconclusive Cytologic Results

The utility of tumor markers CA 125, CA 15-3, and CA 19-9 in assessing the response to therapy in pulmonary and pleural tuberculosis

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