Diagnostic Value of Ultrasound in Fatty Liver Disease

Karlas, Thomas; Blank, Valentin; Böhlig, Albrecht

doi:10.1055/a-1352-4313

Cited by 10 publications

(9 citation statements)

References 60 publications

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“…[25] . This was confirmed by Esfeh et al who reported a decreased sensitivity from 59% (95%CI: 43%-74%) in non-obese patients to 19% (95%CI: 10%-28%) in obese patients (P-value < 0.001) [26] . Technical adjustments, such as the selection of the optimal sound frequency (a low sound frequency allows a higher penetration depth), changing gain and shifting the focus to a deeper region, are necessary to improve image quality [27] .…”

Section: Conventional Ultrasound and Colour Doppler Ultrasoundsupporting

confidence: 61%

Sonography in surveillance for HCC in NAFLD patients

Radu¹,

Dufour²

2022

Hepatoma Res

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Over the last decade, we have been facing a new aetiology responsible for the development of HCC - the non-alcoholic fatty liver disease (NAFLD). The prevalence of HCC development in this group is higher than that observed in the general population and in non-cirrhotic subjects with other causes of liver disease. Conventional ultrasound (US) is the first-line tool for HCC surveillance, but, in this population, it has a decreased diagnostic accuracy due to several particular features, including obesity and steatosis. Contrast-enhanced ultrasound (CEUS) appeared as a new branch of US due to its ability to depict the vascular architecture of all types of focal lesions (FLs). Nevertheless, CEUS has several limitations besides those inherited from US, which renders this method unreliable as the first-line HCC diagnostic tool and for HCC staging. Artificial intelligence eliminates operator limitations, which has led to an increased sensitivity and specificity of US. However, this approach is still in its early stages and more data are needed. Consequently, the purpose of the current study is to highlight the strengths and limits of US, along with its alternatives to HCC screening in NAFLD population.

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Section: Conventional Ultrasound and Colour Doppler Ultrasoundsupporting

confidence: 61%

Sonography in surveillance for HCC in NAFLD patients

Radu¹,

Dufour²

2022

Hepatoma Res

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“…Obesity and related disorders, especially hepatic steatosis, represent commonly accepted limitations to ultrasound imaging quality, and, thus, impair its diagnostic value 3 – 6 . Trained operators may manage these issues by adjustment of ultrasound frequency, gain, and focus settings 7 , but patients with severe obesity remain a challenge even for modern ultrasound devices with advanced post-processing algorithms designed to improve imaging quality.…”

Section: Introductionmentioning

confidence: 99%

The application of high-performance ultrasound probes increases anatomic depiction in obese patients

Heinitz,

Müller,

Jenderka

et al. 2023

Sci Rep

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This study evaluated the impact of obesity on abdominal ultrasound diagnostics and assessed effect of high-performance ultrasound probes increased imaging quality. Lean and obese subjects (n = 40; 58% female) were categorized according to body mass index (BMI, 21 to 48 kg/m2). A highly standardized ultrasound examination of the abdomen was performed by trained examiners using three different probes in randomized order (standard probe versus two high-performance probes). Quality of B-mode and duplex ultrasound were assessed using a custom scoring approach for depiction of liver and kidney anatomy and vascularization. Across probes, imaging quality of hepatic and kidney anatomy was inversely related with BMI (P < 0.03, r < − 0.35). Age, sex, and BMI explained 51% of the variance within the ultrasound quality score, with β = − 0.35, P < 0.0001 for BMI. Compared to the standard probe, high-performance probes allowed for a better depiction of kidney and liver anatomy in subjects above BMI 35 kg/m2 (n = 20, all P < 0.05), resulting in a less pronounced deterioration of imaging quality with increased BMI (all P < 0.05). In conclusion the study shows that obesity impairs ultrasound imaging quality of abdominal anatomy. The application of high-performance probes can increase anatomic depiction in obese patients.Registration number of the German Registry of Clinical Studies: DRKS00023498.

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“…The degree of liver steatosis is quantified by a grading system (grades I–III, see online supplemental table 3 ). 38 In short, this classification is based on echogenicity, attenuation of sound and the visualisation/differentiation of vessels. The echogenicity of the liver is normalised by comparing renal and hepatic parenchyma.…”

Section: Methodsmentioning

confidence: 99%

The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design

et al. 2022

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IntroductionEven well-treated gestational diabetes mellitus (GDM) might still have impact on long-term health of the mother and her offspring, although this relationship has not yet been conclusively studied. Using in-depth phenotyping of the mother and her offspring, we aim to elucidate the relationship of maternal hyperglycaemia during pregnancy and adequate treatment, and its impact on the long-term health of both mother and child.MethodsThe multicentre PREG study, a prospective cohort study, is designed to metabolically and phenotypically characterise women with a 75-g five-point oral glucose tolerance test (OGTT) during, and repeatedly after pregnancy. Outcome measures are maternal glycaemia during OGTTs, birth outcome and the health and growth development of the offspring. The children of the study participants are followed up until adulthood with developmental tests and metabolic and epigenetic phenotyping in the PREG Offspring study. A total of 800 women (600 with GDM, 200 controls) will be recruited.Ethics and disseminationThe study protocol has been approved by all local ethics committees. Results will be disseminated via conference presentations and peer-reviewed publications.Trial registration numberThe PREG study and the PREG Offspring study are registered with Clinical Trials (ClinicalTrials.gov identifiers: NCT04270578, NCT04722900).

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Diagnostic Value of Ultrasound in Fatty Liver Disease

Cited by 10 publications

References 60 publications

Sonography in surveillance for HCC in NAFLD patients

Sonography in surveillance for HCC in NAFLD patients

The application of high-performance ultrasound probes increases anatomic depiction in obese patients

The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design

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