Diagnostic values of calcium and magnesium forms determined in human serum and saliva

Abstract

Calcium and magnesium are known to be necessary for the normal function of various systems in animal and human organisms. There are many diseases caused by abnormal concentration of electrolytes, e.g. arterial hypertension or nervous system diseases such as multiple sclerosis, Mb. Alzheimer or Mb. Parkinson. The mechanisms of homeostasis indicate only the ionized forms of these elements. It is known that ionized calcium serves as an endocellular intermediary in action of enzymes and hormones in cells. Therefore, it is very important to define levels of total and ionized forms of Ca 2+ and Mg 2+ in blood serum and saliva by the method of atomic absorption spectrometry and to show their diagnostic value for various pathological conditions of a human body. The 39 persons, aged 21 to 47 years take part in these investigations. The results of determinations of calcium and magnesium forms present in human serum and saliva, representing physiological states are presented. The age and daily fluctuations of Ca 2+ and Mg 2+ content in serum and saliva were studied by atomic absorption spectrometry. The levels of non albumin forms of these elements were found by FAAS. The significance of determination of calcium and magnesium levels in serum and saliva under various pathological conditions (arterial hypertension and osteoporosis) was shown.

Changes of Serum Concentrations of Alkaline Phosphatase and Metalloproteinase-9 in an Ovariectomized Wistar Rat Model of Osteoporosis

“…Our study has shown that the levels of Ca 2+ , P and Mg 2+ are not changed, which is typical of the initial phase of osteoporosis, during which no signi cant loss of bone mineral density due to active bone remodeling and a compensatory increased osteoblast activity is seen [22,23]. Weight gain in animals in the G2 proves that lack of estrogens due to OVX leads to obesity [24,25].…”

DNA nanotriangle-scaffolded activatable aptamer probe with ultralow background and robust stability for cancer theranostics

“…The poor binding stability of conventional aptamer probes in biofluid is still a critical obstacle to their in vivo application. One important cause is the low level of Mg 2+ in biofluid, which acts as a chaperone in conformational folding of aptamers 29 , 30 . We thereupon investigated the binding property of NTri-SAAP in several representative buffers, including binding buffer, PBS with Mg 2+ supplied (+Mg), and PBS without Mg 2+ supplied (-Mg).…”

ORIGINAL ARTICLE Doppler ultrasonographic assessment of major salivary glands in Type 2 diabetes mellitus patients in correlation with salivary quantity and serum magnesium levels – A cross-sectional study

“…It is involved at multiple levels in insulin secretion, binding, and activity. [11] In our study serum, magnesium levels were similar in control group and Group A whereas it was decreased in Groups B and C. Andrusishina [12] (2010) has evaluated the serum and salivary magnesium levels with calcium levels in diabetic patients. They have observed that the levels of salivary and serum magnesium were nearly equal in normal subjects (n = 12), whereas it was decreased in the experimental groups (n = 27).…”