Diagnostic Values of Serum Levels of Pepsinogens and Gastrin-17 for Screening Gastritis and Gastric Cancer in a High Risk Area in Northern Iran

Abstract

Background: Gastric cancer (GC) is the second cause of cancer related death in the world. It may develop by progression from its precancerous condition, called gastric atrophy (GA) due to gastritis. The aim of this study was to evaluate the accuracy of serum levels of pepsinogens (Pg) and gastrin-17 (G17) as non-invasive methods to discriminate GA or GC (GA/GC) patients. Materials and Methods: Subjects referred to gastrointestinal clinics of Golestan province of Iran during 2010 and 2011 were invited to participate. Serum levels of PgI, PgII and G17 were measured using a GastroPanel kit. Based on the pathological examination of endoscopic biopsy samples, subjects were classified into four groups: normal, non-atrophic gastritis, GA, and GC. Receiver operating curve (ROC) analysis was used to determine cut-off values. Indices of validity were calculated for serum markers. Results: Study groups were normal individuals (n=74), non-atrophic gastritis (n=90), GA (n=31) and GC patients (n=30). The best cut-off points for PgI, PgI/II ratio, G17 and HP were 80 μg/L, 10, 6 pmol/L, and 20 EIU, respectively. PgI could differentiate GA/GC with high accuracy (AUC=0.83; 95%CI: 0.76-0.89). The accuracy of a combination of PgI and PgI/II ratio for detecting GA/GC was also relatively high (AUC=0.78; 95%CI: 0.70-0.86). Conclusions: Our findings suggested PgI alone as well as a combination of PgI and PgI/II ratio are valid markers to differentiate GA/GC. Therefore, Pgs may be considered in conducting GC screening programs in high-risk areas.

Gastric Cancer Screening by Combined Determination of Serum Helicobacter pylori Antibody and Pepsinogen Concentrations

“…[ 42 ] This evidence indicated that the serum PG level was closely correlated with the progression of atrophic gastritis. [ 43 ] Meantime, it indirectly reflected the status of H. pylori infection as well. [ 44 ] It is widely accepted that patients with both serum PG I levels ≤70 ng/ml and PG I/II ratio ≤3.0 were classified as PG-seropositive type and all other situations were classified as PG-seronegative type, using a commercial RIA kit (PG I/II RIA bead kit; Dainabot Co., Tokyo, Japan) with 70.5% sensitivity and 97% specificity.…”

Systematic review with meta‐analysis: diagnostic performance of the combination of pepsinogen, gastrin‐17 and anti‐Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis

“…-No adult population (n=3) 24,25,28 -Accuracy of single tests (n=7) 13,16,27,34,39,40,44 -Different target condition (n=1) 37 -Different reference standard (n=1) 21 -Different outcomes (n=6) 14,22,31,36,41,45 -Overlapping samples (n=1) 17 -No true negatives and false positives (n=1) 43 -Review (n=4) 5,29,32,46 Records identified via electronic searches and screened at title and abstract level after duplicates removed (n=3924)…”

Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion

“…Indeed, our data showed an increased proliferation of gastric cancer cells under low pH. The inducer of acid secretion, gastrin, is proven a valuable biomarker in the screening of gastric cancer . Gastric cancer cells overexpress gastrin as a way to remodel microenvironment to facilitate the outgrowth and metastases.…”