Diagnostic yield of percutaneous image‐guided tissue biopsy of focal hepatic lesions in cancer patients

Abstract

BACKGROUND:The diagnostic yield was evaluated of percutaneous image-guided tissue biopsy of hepatic lesions identified on computed tomography performed for staging of a primary malignancy, and it was determined how often the biopsy result was unexpectedly negative, benign, or secondary to a second unknown malignancy. METHODS: In a retrospective investigation from 1998 through 2008, 580 patients with primary malignancies had indeterminate focal hepatic lesions and underwent percutaneous image-guided biopsy; 369 patients had lesions in their liver at first cross-sectional imaging, performed for staging; 211 patients had a negative liver imaging study, followed by the subsequent appearance of at least 1 indeterminate suspicious lesion. The results of percutaneous image-guided tissue biopsies were compared with the histology of the primary malignancy. RESULTS: Liver biopsies were performed in 580 patients (288 men and 292 women; age, 25-92 years; mean age, 61 years). The most common primary malignancies were pancreatic (n ¼ 96), breast (n ¼ 85), melanoma (n ¼ 57), esophageal (n ¼ 51), lung (n ¼ 47), colorectal (n ¼ 37), and urothelial tumors (n ¼ 26). Biopsy results were positive for malignancy in 528 (91%) cases. Among the positive biopsies, 29 (5%) cases had pathology results different from the primary tumor. Of the 52 biopsies negative for malignancy, 20 yielded a specific benign diagnosis, and 32 were nondiagnostic. CONCLUSIONS: If all liver lesions had been assumed to be metastases, as expected secondary to the known primary tumor, then the true or presumed alternate diagnosis would have been missed in 60 (10.3%) of the 580 cases. The authors did not attempt to determine whether actual clinical management changed based on these 60 liver biopsy results, so this number is an upper bound on management change. On the basis of these results, and given the minimal complication rate of liver biopsy, the authors suggest that liver biopsy should still be performed in the types of cases studied here, despite the finding that the vast majority of biopsies produced the expected result and presumably did not change patient management.

Accuracy of endoscopic ultrasound-guided biopsy of focal liver lesions

“…Ultrasonography (US) or computed tomography (CT) guided liver biopsy are frequently used for the diagnosis of focal liver lesions. Although both methods have a high diagnostic accuracy of approximately 90% [8][9][10][11][12][13], in certain patients, US or CT guidance may be impossible because of suboptimal visualization of small liver lesions or the lesions are difficult to be differentiated from the normal parenchyma.…”

Added Value of Contrast-Enhanced Ultrasound on Biopsies of Focal Hepatic Lesions Invisible on Fusion Imaging Guidance

“…In a previous large series of biopsy studies (28), the rate of misdiagnosis of focal hepatic lesions based on imaging findings was > 10% in cancer patients. Hence, pathological confirmation by biopsy can still play a vital role in the proper management of some cancer patients.…”

An adaptive finite element model for steerable needles

“…Indentation and penetration of soft tissues is a common process in biology and medicine. Minimally invasive surgery by means of needle insertions is successfully applied for tumour biopsy, brachytherapy, deep brain stimulation and localised drug delivery (Elsayes et al 2011;Lobo et al 2012). This has significant benefits for the patient and overall cost of treatment and care; however, percutaneous needle insertions can be difficult to target and control, and surgical interventions in delicate organs need to be precise and accurate.…”

“…Minimally invasive surgery by means of needle insertions is successfully applied for tumour biopsy, brachytherapy, deep brain stimulation and localised drug delivery (Elsayes et al. 2011 ; Lobo et al. 2012 ).…”