Diagnostic yield of <scp>T</scp>hin<scp>P</scp>rep preparation in the assessment of fine‐needle aspiration biopsy of salivary gland neoplasms

Hipp, Jennifer; Lee, Beatrice; Spector, Matthew E.; Jing, Xin

doi:10.1002/dc.23188

Cited by 12 publications

(21 citation statements)

References 12 publications

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“…In these two studies, the proportion of ND cytology was determined to be higher in TP samples compared to CSs. Hipp et al evaluated 178 nonsplit‐sample TP preparations and the ND rate was reported to be 40% for TP samples. In the current study, while ND aspirates constituted 16.1% of 459 liquid‐based preparations, this rate was 7% of 129 follow‐up patients in nonsplit‐samples.…”

Section: Discussionmentioning

confidence: 99%

“…The smears are stained with Giemsa, hematoxylin–eosin, and/or Papanicolaou stains. The sensitivity and specificity rates of salivary gland FNAs have been reported as 63%‐93% and 90%‐100%, respectively, when using CS preparations …”

Section: Introductionmentioning

confidence: 99%

“…Architecture, extracellular matrix material, and inflammatory component play an important role in the diagnosis of salivary gland lesions . In the literature, the sensitivity, specificity, and diagnostic accuracy of salivary gland FNA using a LBC technique have been demonstrated in a limited number of studies …”

Section: Introductionmentioning

confidence: 99%

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The risk of malignancy according to Milan reporting system of salivary gland fine‐needle aspiration with Becton Dickinson SurePath liquid‐based processing

Sadullahoğlu¹,

Yıldırım²,

Çekiç³

et al. 2019

Diagnostic Cytopathology

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Background Fine‐needle aspiration cytology (FNAC) is a noninvasive, safe, cost‐effective, diagnostic procedure for the evaluation of salivary gland lesions and the selection of patients for surgery. The aim of this study was to analyze the risk of malignancy (ROM) according to the Milan reporting system of salivary gland FNA specimens using a liquid‐based cytology (LBC) technique. Methods The cytological diagnosis of 459 cases between 2014 and 2017 was revised according to the Milan reporting system. The FNAC results of 129 cases with a histological diagnosis were compared with respect to the final diagnosis. The ROM for each category calculated. Results The ROM was high in the indeterminate and malignant categories, while the ROM in the benign neoplasm category was low. Sensitivity and specificity analyzed in two different ways were 95.1% and 88.8%, 81%, and 77.7%, respectively. Conclusions When salivary gland lesions are evaluated together with clinical and radiological data, the LBC technique can be applied to salivary gland specimens based on the high diagnostic sensitivity and specificity in liquid‐based samples reported according to the Milan system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The risk of malignancy according to Milan reporting system of salivary gland fine‐needle aspiration with Becton Dickinson SurePath liquid‐based processing

Sadullahoğlu¹,

Yıldırım²,

Çekiç³

et al. 2019

Diagnostic Cytopathology

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“…A recent study by Hipp et al [4] reported their review of 369 FNA of salivary gland aspirates with neoplastic follow-up. Of these, 178 were processed by TP only and 191 were processed by CS only or in combination with TP.…”

Section: Discussionmentioning

confidence: 99%

“…This methodology has several advantages over conventional smears (CS), including the following: (1) more standardized processing, especially with samples received from outside clinics or shipped from a distance to centralized laboratories; (2) decreased screening area; (3) decreased obscuring material such as blood, inflammation and mucus; (4) lack of air-drying artifacts; (5) a more monolayer cellular surface that is easier to screen; (6) consistently well-preserved cells, and (7) the potential for automated screening in LBC specimens [1,2,3,4]. Because of the many advantages of LBC, the technique has been increasingly adopted by many laboratories for nongynecological specimens, particularly exfoliative samples.…”

Section: Introductionmentioning

confidence: 99%

The Utility of Liquid-Based Cytology in Salivary Gland Fine-Needle Aspirates: Experience of an Academic Institution

Rarick

Wasman²,

Michael³

2014

Acta Cytologica

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Objective: To review the morphological features of salivary gland fine-needle aspirates (FNA) on ThinPrep® (TP) preparations. Emphasis is placed on the commonalities and specific differences between TP and conventional smear (CS) preparations. Study Design: The cytology and surgical pathology archives were searched for ‘salivary' or ‘parotid' at our institution from 2003 to 2013 for cases processed by TP and with a range of specified diagnoses and surgical follow-up. These cases were reviewed by the authors. A review of the known literature was also performed. Results: Morphological features and artifacts were noted for the most common salivary gland lesions. General features noted in the literature were identified, along with novel features identified on our review of cases. Emphasis was placed on cellular alterations, extracellular differences and architectural changes. Conclusions: The multitude of both benign and malignant lesions coupled with the unique artifacts encountered on TP makes salivary gland FNAs difficult for most practicing pathologists and cytopathologists. For this reason, many laboratories have been reluctant to implement TP preparations for these lesions. With knowledge of the specific artifacts and differences on TP compared to CS, TP can be used with confidence without a compromise in diagnostic accuracy for adequately cellular samples.

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The impact of FNAC in the management of salivary gland lesions: Institutional experiences leading to a risk‐based classification scheme

Rossi

Wong

Bizzarro

et al. 2016

Cancer Cytopathology

127

174

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BACKGROUND: Fine-needle aspiration cytology (FNAC) has proven its value as an essential step in the diagnosis of salivary gland lesions. Although the majority of salivary gland lesions, especially those that are common and benign, can be diagnosed with ease on FNAC, limited cellularity and morphologic lesion heterogeneity can pose diagnostic challenges and lead to false-positive and false-negative diagnoses. This study presents the institutional experience of FNAC of salivary gland lesions from 2 academic centers. METHODS: A retrospective analysis was conducted on 1729 salivary gland FNAC specimens that were diagnosed over an 8-year period from January 2008 to March 2015. All samples were processed either with liquid-based cytology alone or in combination with air-dried, Diff-Quik-stained or alcohol-fixed, Papanicolaou-stained smears. RESULTS: Surgical excision was performed in 709 of 1749 FNACs (41%) that were diagnosed as nondiagnostic/inadequate (n 5 29), benign (n 5 111), neoplasm (n 5 453), atypical (n 5 15), suspicious for malignancy (n 5 28), and malignant (n 5 73). The overall concordance between cytologic and histologic diagnoses was 92.2%, with 91.8% concordance in the benign category and 89.5% concordance in cases diagnosed as suspicious for malignancy and malignant. The most frequent benign and malignant lesions were pleomorphic adenoma and squamous cell carcinoma, respectively. There were 46 false-negative and 13 false-positive results, leading to an overall specificity of 97.6% and diagnostic accuracy of 91.3%. CONCLUSIONS: FNAC is a reliable diagnostic modality for the diagnosis and management of salivary gland lesions based on its high specificity and diagnostic accuracy. Cancer Cytopathol 2016;124:388-96. V C 2016 American Cancer Society.

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Diagnostic yield of ThinPrep preparation in the assessment of fine‐needle aspiration biopsy of salivary gland neoplasms

Abstract: ThinPrep may be considered as another practical method of specimen preparation in the assessment of salivary gland neoplasms, particularly when FNA is performed without immediate assistance from cytology.

Cited by 12 publications

References 12 publications

The risk of malignancy according to Milan reporting system of salivary gland fine‐needle aspiration with Becton Dickinson SurePath liquid‐based processing

The risk of malignancy according to Milan reporting system of salivary gland fine‐needle aspiration with Becton Dickinson SurePath liquid‐based processing

The Utility of Liquid-Based Cytology in Salivary Gland Fine-Needle Aspirates: Experience of an Academic Institution

The impact of FNAC in the management of salivary gland lesions: Institutional experiences leading to a risk‐based classification scheme

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