Diagnostic yield of the lactate stress test in 160 patients with suspected respiratory chain disorder

Finsterer, Josef; Obermann, Ingrid; Milvay, Erika

doi:10.1007/bf02674525

Cited by 17 publications

(20 citation statements)

References 13 publications

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“…Other tests use an absolute workload, for example 30 W (Finsterer et al 2000). For some authors, for research purposes, it should be performed both a relative and an absolute exercise intensity test (McKenzie et al 2000).…”

Section: Exercise Testing In MDmentioning

confidence: 99%

Functional Diagnostics in Mitochondrial Diseases

et al. 2007

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Mitochondrial diseases (MD) with respiratory chain defects are caused by genetic mutations that determine an impairment of the electron transport chain functioning. Diagnosis often requires a complex approach with measurements of serum lactate, magnetic resonance spectroscopy (MRS), muscle histology and ultrastructure, enzymology, genetic analysis, and exercise testing. The ubiquitous distribution of the mitochondria in the human body explains the multiple organ involvement. Exercise intolerance is a common symptom of MD, due to increased dependence of skeletal muscle on anaerobic metabolism, with an excess lactate generation, phosphocreatine depletion, enhanced free radical production, reduced oxygen extraction and electron flux through the respiratory chain. MD treatment has included antioxidants (vitamin E, alpha lipoic acid), coenzyme Q10, riboflavin, creatine monohydrate, dichloroacetate and exercise training. Exercise is a particularly important tool in diagnosis as well as in the management of these diseases.

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Section: Exercise Testing In MDmentioning

confidence: 99%

Functional Diagnostics in Mitochondrial Diseases

et al. 2007

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“…The LST comprised serum lactate determination before, during, and after a standard, continuous exercise on a cycle ergometer (Finsterer, 2003;Finsterer et al, 2000). Before the test patients had to rest for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Lactate Stress Testing in Sporadic Amyotrophic Lateral Sclerosis

Finsterer

2005

International Journal of Neuroscience

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Mitochondrial dysfunction is frequently observed in ALS. Mitochondrial dysfunction may result in increased serum lactate at rest or low levels of exercise, being used for diagnostic purposes. The study investigated if resting-lactate-determination is superior to lactate-stress-testing (LST) in demonstrating mitochondrial dysfunction in ALS. Included were 15 ALS patients, 4 women, 11 men, aged 37-72. Severity of the disease was assessed by the Norris-score. The control group comprised 66 healthy subjects, 40 women, 26 men, aged 36-76. Serum lactate was determined before, three times during, and once after a constant workload with 30 W on a bicycle ergometer. According to the EIEscorial criteria 8 patients had definite, 4 probable, 3 possible ALS. Resting lactate was increased in 2 patients, 1 with definite and 1 with possible ALS. The LST was abnormal in 5 patients with definite, 1 with probable and 1 with possible ALS. The mean Norris-score was 67.8 in patients with abnormal LST and 74.6 in patients with normal LST. In conclusion, the LST is more suitable than resting-lactate-determination in demonstrating mitochondrial dysfunction in ALS. The LST suggests mitochondrial dysfunction in half of the ALS patients. Mitochondrial dysfunction in ALS is related to the clinical severity of the disease.

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“…Patients with MM present an increase in the lactate production at lower levels of exercise, compared to healthy subjects [67], with an early anaerobic threshold [63] (Fig. 3).…”

Section: Aerobic Exercise Testmentioning

confidence: 96%

“…No unique standardized protocols, at the moment, have been established. The aerobic exercise test can be performed following an incremental cycle test [62][63][64], a cycle test with a fixed constant absolute workload [65][66][67], or a protocol with a constant ''relative'' workload, normalized to the presumed V02max or to the estimated maximal possible work capacity [68,69].…”

Section: Aerobic Exercise Testmentioning

confidence: 99%

Metabolic myopathies: functional evaluation by different exercise testing approaches

et al. 2011

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Metabolic myopathies are a clinically and etiologically heterogeneous group of disorders due to defects in muscular energy metabolism. They include glycogen storage diseases, fatty acid oxidation defects, and mitochondrial disorders. The typical manifestations of a metabolic myopathy are exercise-induced myalgias, exercise intolerance, and cramps. Evaluating subjects with such symptoms is not easy because of the frequent lack of clinical features. Exercise tests are, therefore, reliable screening tools. Here, we discuss the possible role of such exercise testing techniques in the diagnostic approach of a patient with suspected metabolic myopathy.

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Diagnostic yield of the lactate stress test in 160 patients with suspected respiratory chain disorder

Cited by 17 publications

References 13 publications

Functional Diagnostics in Mitochondrial Diseases

Functional Diagnostics in Mitochondrial Diseases

Lactate Stress Testing in Sporadic Amyotrophic Lateral Sclerosis

Metabolic myopathies: functional evaluation by different exercise testing approaches

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