Diagnostic Yield of Wireless Capsule Enteroscopy in Comparison with Computed Tomography Enteroclysis

Voderholzer, Winfried A.; Ortner, M.; Rogalla, P.; Beinhölzl, J.; Lochs, Herbert

doi:10.1055/s-2003-44583

Cited by 190 publications

(116 citation statements)

References 10 publications

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“…Previous studies investigating the yield of WCE in the detection of small intestinal lesions in comparison with various imaging techniques have shown that WCE is superior to CT enteroclysis and small-bowel follow-through [18][19][20][21]. Indeed, the introduction of WCE has significantly improved the diagnostic yield of small bowel tumors whose detection has been notoriously challenging due to the limitations of other imaging modalities.…”

Section: Discussionmentioning

confidence: 99%

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Furnari

Buda²,

Delconte

et al. 2017

JGLD

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Background & Aims: Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with unclear etiology that may show functioning or non-functioning features. Primary tumor localization often requires integrated imaging. The European Neuroendocrine Tumors Society (ENETS) guidelines proposed wireless-capsule endoscopy (WCE) as a possible diagnostic tool for NETs, if intestinal origin is suspected. However, its impact on therapeutic management is debated. We aimed to evaluate the yield of WCE in detecting intestinal primary tumor in patients showing liver NET metastases when first-line investigations are inconclusive.Method: Twenty-four patients with histological diagnosis of metastatic NET from liver biopsy and no evidence of primary lesions at first-line investigations were prospectively studied in an ENETS-certified tertiary care center. Wireless-capsule endoscopy was requested before explorative laparotomy and intra-operative ultrasound. The diagnostic yield of WCE was compared to the surgical exploration.Results: Sixteen subjects underwent surgery; 11/16 had positive WCE identifying 16 bulging lesions. Mini-laparotomy found 13 NETs in 11/16 patients (9 small bowel, 3 pancreas, 1 bile ducts). Agreement between WCE and laparotomy was recorded in 9 patients (Sensitivity=75%; Specificity=37.5%; PPV=55%; NPV=60%). Correspondence assessed per-lesions produced similar results (Sensitivity=70%; Specificity=25%; PPV=44%; NPV=50%). No capsule retentions were recorded.Conclusions: Wireless-capsule endoscopy is not indicated as second-line investigation for patients with gastro-entero-pancreatic NETs. In the setting of a referral center, it might provide additional information when conventional investigations are inconclusive about the primary site.Abbreviations: DBE: double balloon enteroscopy; GEP-NET: gastro-entero-pancreatic neuroendocrine tumor; GI: gastrointestinal; ENETS: European Neuroendocrine Tumor Society; NET: neuroendocrine tumor; SSRS: somatostatin receptor scintigraphy; WCE: wireless capsule endoscopy.

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Section: Discussionmentioning

confidence: 99%

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Furnari

Buda²,

Delconte

et al. 2017

JGLD

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“…CT has now emerged as the imaging modality of choice [37][38][39][40] . Magnetic resonance imaging (MRI) [41] , double-contrast enteroclysis [42] , and video wireless capsule endoscopy [43,44] have also been promising. Survival rates for small bowel malignancies are much worse than for large bowel cancers with a mean survival of 6 mo as compared to 65 mo for the latter [9] .…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic ileal adenocarcinoma in the setting of undiagnosed Crohn’s disease

Reddy

Aslanian²,

Suh³

et al. 2008

WJG

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“…CE has a high diagnostic yield in OGIB, facilitates effective decision-making regarding subsequent investigations and treatments .Diagnostic yield of CE for OGIB varied between 31% and 91% (Adler et al,2004;Costamagna et al,2004;Ell et al,2002;Ersoy et al,2006;Ge et al,2004;Golder et al,2006;Hartmann et al 2003Hartmann et al ,2005Lewis & Swain,2002;Mata et al,2004;Panazio et al,2004;Scapa et al,2002;Saurin et al,2003;Saperas et al,2007;Van gossum et al,2003;Voderholzer et al,2003). The published studies of CE for OGIB were reviewed and reported that sensitivity ranged from 79% to 95% and specificity from 75% to 100% (Varela Lema & Ruano-Ravina, 2008 ).…”

Section: Obscure Gi Bleedingmentioning

confidence: 99%

Capsule Endoscopy: A Comprehensive Review

Jain¹,

Jain²

2011

New Techniques in Gastrointestinal Endoscopy

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Diagnostic Yield of Wireless Capsule Enteroscopy in Comparison with Computed Tomography Enteroclysis

Abstract: Wireless capsule enteroscopy detects more small-bowel lesions than CT enteroclysis in patients with obscure gastrointestinal bleeding and Crohn's disease.

Cited by 190 publications

References 10 publications

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Asymptomatic ileal adenocarcinoma in the setting of undiagnosed Crohn’s disease

Capsule Endoscopy: A Comprehensive Review

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