Diagnostically Challenging Epithelioid Vascular Tumors

Ko, Jennifer S.; Billings, Steven D.

doi:10.1016/j.path.2015.05.001

Cited by 47 publications

(40 citation statements)

References 61 publications

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“…Immunohistochemically, the tumor cells were stained diffusely positive for CD34 and vimentin but were negative for pancytokeratin, smooth muscle actin, S100, and desmin (2,8). However, there have been cases that stained positive for cytokeratin and smooth muscle actin reported in the literature (9).…”

Section: Discussionmentioning

confidence: 98%

“…In the histopathologic examination, EHE create islands and cords on hyalinized and myxoid ground substance, and consist of intracytoplasmic vacuoles that contain typical erythrocytes and are characterized by fusiform or round nucleated cells (2). Immunohistochemically, the tumor cells were stained diffusely positive for CD34 and vimentin but were negative for pancytokeratin, smooth muscle actin, S100, and desmin (2,8).…”

Section: Discussionmentioning

confidence: 99%

“…Adenocarcinomas take first place in the differential diagnosis of EHE because of epithelioid morphology and intracytoplasmic vacuoles (2). Therefore, it is crucial for EHE to be separated from metastasis particularly when treating patients with carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Epithelioid hemangioma, pseudomyogenic (epithelioid sarcoma-like) HE, epithelioid angiosarcoma, and epithelioid sarcoma are included in the differential diagnosis for the histologically epithelioid appearance of cells (2,4). Epithelioid hemangioma is a benign vascular tumor and has the appearance of the so-called 'tombstone' pattern with epithelioid endothelial cells lining vessels (2, 4).…”

Section: Discussionmentioning

confidence: 99%

“…EHE may develop as a solitary mass in middle-aged patients. They usually present in deep soft tissues, internal organs (the lungs and liver in particular), bones and skin (2)(3)(4). It accounts for less than 1% of all vascular tumors (3).…”

Section: Introductionmentioning

confidence: 99%

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A Rare Tumor that Mimicked Metastasis in a Patient with Breast Cancer: Epithelioid Hemangioendothelioma

et al. 2016

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A woman aged 50 years was diagnosed as having an invasive ductal carcinoma in the right breast and ductal carcinoma in situ in the left breast and underwent bilateral mastectomy eight years ago. A mass was identified during follow-up in positron-emission tomography (PET) image in the left infraclavicular region, indicating metastasis. Histopathologic examination showed a mass of 1.9 x 1 x 0.7 cm in dimensions characterized by spindle or round nuclei cells that formed island or cords in hyaline and myxoid ground and intracytoplasmic vacuoles containing erythrocytes. In the immunohistochemical analysis, tumor cells were widespread with diffuse positivity with CD34 and vimentin. These findings redirected us from a diagnosis of metastatic carcinoma to epithelioid hemangioendothelioma, a rare tumor of intermediate vascular tumor groups. In this respect, confirmation through biopsy from considered cases of metastasis is important in making a definite pathologic differential diagnosis.

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Section: Discussionmentioning

confidence: 98%