Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

Koufopoulos, Nektarios; Pateras, Ioannis S.; Gouloumis, Alina Roxana; Ieronimaki, Argyro Ioanna; Zacharatou, Andriani; Spathis, Aris; Leventakou, Danai; Economopoulou, Panagiota; Psyrri, Amanda; Arkadopoulos, Nikolaos; Panayiotides, Ioannis G.

doi:10.3390/diagnostics12112658

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…Notably, the tumor cells exhibited blue staining of intra-and extracellular material suggestive of mucin production. While intracellular and extracellular mucin secretion is a recognized feature of lobular breast carcinoma, the identification of such mucins within the metastatic tumor is a rare occurrence [30,31,33,49]. Some studies suggest that mucin production may signify aggressive behavior in lobular carcinoma [31].…”

Section: Discussionmentioning

confidence: 99%

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Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review

Faur,

Gurban,

Dăescu

et al. 2024

Diagnostics

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Breast cancer stands as the primary cause of cancer-related mortality among women worldwide, often presenting with distant metastases upon diagnosis. Ovarian metastases originating from breast cancer represent a range of 3–30% of all ovarian neoplasms. Case Report: Herein, we present the histopathological, histochemical, and immunohistochemical findings of a rare case involving mucin-producing lobular breast carcinoma metastasizing to an ovarian fibroma in an 82-year-old female previously diagnosed with lobular breast carcinoma. Histopathological examination of the excised tissues revealed a biphasic neoplasm characterized by tumor cells expressing AE-1/AE-3 cytokeratin, mammaglobin, GCDFP-15, inhibin, and calretinin. Positive mucin staining was observed using histochemical techniques, and reticulin fibers were demonstrated using the Gordon–Sweets technique. A final diagnosis of mucin-producing lobular breast carcinoma metastatic to a benign ovarian fibroma was rendered. Conclusion: The occurrence of metastatic breast carcinoma overlaid on an ovarian tumor represents a rare and diagnostically challenging scenario.

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Section: Discussionmentioning

confidence: 99%

“…The stromal Diagnostics 2024, 14, 953 2 of 10 response in ILC is minimal, and necrosis is uncommon. Morphological variants of ILC are classic lobular carcinoma, solid, alveolar, tubulolobular, pleomorphic, histocytoid, apocrine, signet ring, and mixed [30]. Also, variants of ILC with mucin production have been described [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review

Faur,

Gurban,

Dăescu

et al. 2024

Diagnostics

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Transfer learning for accelerated failure time model with microarray data

Pei,

Yu,

Shen

2024

Preprint

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Background: In microarray prognostic studies, we expect to identify genes that are associated with disease-free survival or overall survival. However, due to the rarity of the disease and the cost of sample collection, we face the challenge of limited sample size, which may prevent accurate risk assessment. It necessitates the method that can utilize information from similar studies or data for gene selection and risk assessment of the target task. Results: We model the time-to-event data using the accelerated failure time model (AFT). We propose a transfer learning method for the AFT model to improve the fit on the target cohort by borrowing information from source cohorts adaptively. The Lasso penalty is used for gene selection and regularized estimation. We use Leave-One-Out cross validation based methods for evaluating the relative stability of individual genes and overall prediction significance. Conclusion: We demonstrate through simulation studies that the transfer learning method for the AFT model can correctly identify a small number of genes, its estimation error is smaller than the corresponding error without using source cohorts. Meanwhile, the proposed method demonstrates satisfactory robustness and accuracy against cohort heterogeneity compared to the method that directly combines the target and source cohorts in the AFT model. We analyze the GSE88770 data and the GSE25055 data using the proposed method. The selected genes are relatively stable, and the proposed method has overall satisfactory prediction power.

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The “Forgotten” Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors

Koufopoulos,

Boutas,

Pouliakis

et al. 2024

IJMS

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Breast carcinoma is the most common cancer in women. Nineteen different subtypes of breast carcinomas are recognized in the current WHO classification of breast tumors. Except for these subtypes, there are a number of carcinomas with special morphologic and immunohistochemical features that are not included in the 5th WHO classification, while others are considered special morphologic patterns of invasive breast carcinoma of no special type. In this manuscript, we systematically review the literature on four different subtypes of invasive breast carcinoma, namely lymphoepithelioma-like breast carcinoma, breast carcinoma with osteoclast-like giant cells, signet-ring breast carcinoma, and metaplastic breast carcinoma with melanocytic differentiation. We describe their clinicopathological characteristics, focusing on the differential diagnosis, treatment, and prognosis.

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Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

Cited by 3 publications

References 50 publications

Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review

Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review

Transfer learning for accelerated failure time model with microarray data

The “Forgotten” Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors

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