Diagnóstico molecular de la sífilis

Guerra, Lenin Cavalcanti Brito; Valdés, Fernando

doi:10.1016/j.eimc.2020.02.002

Cited by 13 publications

(2 citation statements)

References 35 publications

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“…Syphilis can be categorized into acquired syphilis and congenital syphilis [24]. Currently, commonly used laboratory tests include specifc treponemal antibody tests and nonspecifc treponemal antibody tests [25]. Research has demonstrated that the expression and function of miRNAs confer important roles in early diagnosis, disease assessment, and prognosis of syphilis.…”

Section: Role Of Mirnas In Syphilismentioning

confidence: 99%

MicroRNAs as Potential Biomarkers for the Diagnosis, Treatment, and Prognosis of Sexually Transmitted Diseases: Recent Advances and Future Directions

Li,

Wang,

et al. 2024

Dermatologic Therapy

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Sexually transmitted diseases (STDs), including condyloma acuminatum (CA), syphilis, gonorrhea, genital Chlamydia trachomatis (CT), and acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection, are a group of diseases primarily transmitted through sexual contact, similar behaviors, and indirect contact. These diseases exert a profound impact on both the physical and mental health of patients and impose a substantial socioeconomic burden. Nonetheless, there is a lack of satisfactory treatment options and preventive strategies currently. Research has revealed aberrant expression patterns of microRNAs (miRNAs) in the tissues and blood of individuals with STDs, which are involved in the regulation of essential cellular processes, including proliferation, differentiation, and apoptosis. Consequently, miRNAs hold promise as crucial biomarkers for early diagnosis, disease assessment, prognosis, and potential therapeutic targets for STDs. This systematic review presents pertinent research on miRNAs in the context of STDs to establish a theoretical foundation for clinical diagnosis and treatment strategies.

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Section: Role Of Mirnas In Syphilismentioning

confidence: 99%

MicroRNAs as Potential Biomarkers for the Diagnosis, Treatment, and Prognosis of Sexually Transmitted Diseases: Recent Advances and Future Directions

Li,

Wang,

et al. 2024

Dermatologic Therapy

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“…Furthermore, confirming a diagnosis of chancre is based mainly on serology, as direct diagnosis by dark-field microscopy presents difficulties that limit its widespread use. [4] However, the results of serologic nontreponemal tests are only positive in 50% of patients with primary syphilis. [5] Furthermore, false-negative serologic test results have been reported previously in early syphilis/HIV coinfection [6] and the prozone phenomenon.…”

mentioning

confidence: 99%

The Great Imitator: Atypical Cutaneous Manifestations of Primary Syphilitic Chancre

Gong

et al. 2021

Chinese Medical Sciences Journal

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Objective To evaluate the reasons of misdiagnosis of primary syphilitic chancre and strengthen the understanding of atypical features of this disease.Methods A case series of twenty-seven challenging primary syphilis cases who were not immediately recognized as chancre was included in our study. The clinical data including the patients' age, sex, skin lesions, HIV status, syphilis serologic test results, treatment, and follow-up results were collected. Hematoxylineosin and immunohistochemistry staining of skin biopsy sections were reviewed. ResultsAll misdiagnosed female cases involved extragenital chancres presenting as erythema or erosive skin lesions on the nipple, misdiagnosed as Paget's disease or eczema. Missed or misdiagnosed male cases presented as multiple lesions/syphilitic balanitis, chancre on the penis root and adjacent pubis rather than coronal sulcus or frenum. Patients with nonreactive nontreponemal tests at initial presentation were also easily missed or misdiagnosed. ConclusionIt is easy to miss or misdiagnose primary syphilis presenting with multiple lesions rather than a single chancre, at atypical locations, or with a nonreactive nontreponemal test result.Syphilis, a multistage sexually transmitted disease, caused by Treponema pallidum, remains a major global health problem. The incidence of syphilis has increased strikingly during the last three decades in China, the average annual increase having been as high as 16.3%. [1]

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