Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case)

Старшинова, Анна; Guglielmetti, Lorenzo; Rzhepishevska, Olena; Ekaterincheva, O. L.; Zinchenko, Ulia; Kudlаy, D.А.

doi:10.1016/j.jctube.2021.100259

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Like the majority of the studies, the presence of comorbidities is not associated with an increased risk of developing pneumothorax, but some suggest patients with an underlying lung disease have an increased incidence. 1,4,7,[14][15][16] This study also found that those under the age of 35 had a lower incidence of the disease, unlike the conclusion made by other studies.…”

Section: Discussioncontrasting

confidence: 76%

“…The mortality rate has ranged from 47.2% to 86.3%. 3,4,7,8,11,12,[14][15][16] The association between inhospital mortality and pneumothorax was also reported in another meta-analysis. 17 This study found that 94.3% of COVID-19 patients with pneumothorax admitted to the ICU died, compared to 74.3% of those without pneumothorax.…”

supporting

confidence: 61%

“…Our study showed that 63.8% of the patients with pneumothorax were men, this could be explained by smoking status which is common in men, and this result agrees with findings in many papers. 1,3,4,8,9,11,14,15 Cough (97.8%), shortness of breath (90.4%), fatigue (81.9%), and fever (76.6%) were the most common symptoms among this group. Laboratory parameters in these patients showed that they were more likely to have an elevated white count.…”

Section: Discussionmentioning

confidence: 92%

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Determinants of Pneumothorax Among Mechanically Ventilated COVID-19 Intensive Care Unit Patients, a Single Centre Study

Hundie,

Alemu,

Getachew

et al. 2023

JMDH

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Millions of deaths and co-morbidities have been brought on by the COVID-19 epidemic worldwide. Acute respiratory distress syndrome (ARDS), multiple organ failure, and death can result from the condition in some people. The disease's course can range from a moderate upper respiratory tract infection to severe pneumonia. Numerous reports have been made on the occurrence of pneumothorax in COVID-19 ICU patients, particularly in those who are receiving invasive ventilation. This study assesses factors associated with pneumothorax among mechanically ventilated COVID-19 ICU patients in Addis Ababa, Ethiopia. Methods: A case-control study design was employed from August 1, 2022, to August 31, 2022, GC, with a sample size of 281, where cases are 94 and controls are 187. A pre-tested structured quantitative tool was used to collect data on ODK and export it to SPSS version 26 for analysis. Descriptive statistics were presented using text and tables. The association between variables was analyzed with binary logistic regression. A statistical significance was declared at a p-value of 0.05 with a 95% confidence interval. Assumptions like model fitness and multicollinearity were checked to be satisfied. Results: A total of 281 (94 cases and 187 controls) patient charts were carefully reviewed. After adjustment for possible confounders in multivariate analysis, ARDS (AOR = 0.214, 95% CI (0.088, 0.519), P value =0.001) and invasive ventilation (AOR = 0.311, 95% CI (0.121, 0.796), P value =0.015) had a significant association with pneumothorax. Conclusion: Despite the introduction of preventive breathing methods, pneumothorax is still a frequent and deadly consequence in COVID-19 patients with ARDS. ARDS and invasive mechanical ventilation were found to be significantly associated with the development of pneumothorax. Health facilities should be well equipped with recent medical equipment in intensive care units and with well-trained and organized manpower.

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Section: Discussioncontrasting

confidence: 76%

supporting

confidence: 61%

Section: Discussionmentioning

confidence: 92%

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Determinants of Pneumothorax Among Mechanically Ventilated COVID-19 Intensive Care Unit Patients, a Single Centre Study

Hundie,

Alemu,

Getachew

et al. 2023

JMDH

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“…The postoperative wound area had residual subcutaneous emphysema. Two nucleic acid tests for SARS-CoV-2 yielded negative results, and the patient was transferred to a TB hospital for further management ( 195 ).…”

Section: Diagnostic Challenges and Management Of Covid-19-tb Casesmentioning

confidence: 99%

Pathogenesis of SARS-CoV-2 and Mycobacterium tuberculosis Coinfection

Shah

Shah²,

Yasmeen³

et al. 2022

Front. Immunol.

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Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is an infectious disease that poses severe threats to global public health and significant economic losses. The COVID-19 global burden is rapidly increasing, with over 246.53 million COVID-19 cases and 49.97 million deaths reported in the WHO 2021 report. People with compromised immunity, such as tuberculosis (TB) patients, are highly exposed to severe COVID-19. Both COVID-19 and TB diseases spread primarily through respiratory droplets from an infected person to a healthy person, which may cause pneumonia and cytokine storms, leading to severe respiratory disorders. The COVID-19-TB coinfection could be fatal, exacerbating the current COVID-19 pandemic apart from cellular immune deficiency, coagulation activation, myocardial infarction, and other organ dysfunction. This study aimed to assess the pathogenesis of SARS-CoV-2-Mycobacterium tuberculosis coinfections. We provide a brief overview of COVID19-TB coinfection and discuss SARS-CoV-2 host cellular receptors and pathogenesis. In addition, we discuss M. tuberculosis host cellular receptors and pathogenesis. Moreover, we highlight the impact of SARS-CoV-2 on TB patients and the pathological pathways that connect SARS-CoV-2 and M. tuberculosis infection. Further, we discuss the impact of BCG vaccination on SARS-CoV-2 cases coinfected with M. tuberculosis, as well as the diagnostic challenges associated with the coinfection.

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Explainable Augmented Intelligence and Deep Transfer Learning for Pediatric Pulmonary Health Evaluation

Marvin

Alam

2022

2022 International Conference on Innovations in Science, Engineering and Technology (ICISET)

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Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case)

Cited by 4 publications

References 16 publications

Determinants of Pneumothorax Among Mechanically Ventilated COVID-19 Intensive Care Unit Patients, a Single Centre Study

Determinants of Pneumothorax Among Mechanically Ventilated COVID-19 Intensive Care Unit Patients, a Single Centre Study

Pathogenesis of SARS-CoV-2 and Mycobacterium tuberculosis Coinfection

Explainable Augmented Intelligence and Deep Transfer Learning for Pediatric Pulmonary Health Evaluation

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