Diagnostics of contrastinduated nephropathy after percutaneous coronary intervention

Abstract

The present study is devoted to search for the opportunities of early diagnosis of the development of contrastinduced nephropathy when performing coronary angiography and percutaneous coronary intervention in patients with a chronic ischemic heart disease. The predicative ability of modern biomarkers was studied in comparison with serum creatinine. Baseline serum β2-microglobulin levels >1.1 mg/l can be attributed to patients at a high risk of developing complications. Increasing the level of cystatin C in the blood by 25 % from baseline after 24 hours or >1.064 mg/l, increasing the level of β2-microglobulin in blood after 24 hours > 1.42 mg/l allows you to diagnose acute kidney damage, before the creatinine dynamics and can be used in routine clinical practice. The determination of neutrophil lipocalin in the urine improves the accuracy of diagnosis, but is difficult in routine practice.