2022
DOI: 10.3390/diagnostics12051071
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Diagnostics of HNSCC Patients: An Analysis of Cell Lines and Patient-Derived Xenograft Models for Personalized Therapeutical Medicine

Abstract: Head and neck squamous cell carcinomas (HNSCC) are very frequent worldwide, and smoking and chronic alcohol use are recognized as the main risk factors. For oropharyngeal cancers, HPV 16 infection is known to be a risk factor as well. By employing next-generation sequencing, both HPV-positive and negative HNSCC patients were detected as positive for PI3K mutation, which was considered an optimal molecular target. We analyzed scientific literature published in the last 5 years regarding the newly available diag… Show more

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Cited by 5 publications
(2 citation statements)
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“…The basic diagnostic path for head and neck cancers includes primarily imaging diagnostics (endoscopy, head MRI, CT of the sinuses and head, panoramic dental x-ray, dental cone beam CT, PET/CT) supported by histopathological tests [19]. At the same time, the pursuit of faster, more effective and less invasive diagnostic methods leads to the introduction of innovative tests such as immunochemistry [20,21], molecular analyses [22][23][24], ultrasound elastography [25,26] or Raman spectroscopy [27]. There are even reports of the use of Artificial Intelligence-based methods in head and neck cancer diagnosis [28].…”
Section: Head and Neck Cancermentioning
confidence: 99%
“…The basic diagnostic path for head and neck cancers includes primarily imaging diagnostics (endoscopy, head MRI, CT of the sinuses and head, panoramic dental x-ray, dental cone beam CT, PET/CT) supported by histopathological tests [19]. At the same time, the pursuit of faster, more effective and less invasive diagnostic methods leads to the introduction of innovative tests such as immunochemistry [20,21], molecular analyses [22][23][24], ultrasound elastography [25,26] or Raman spectroscopy [27]. There are even reports of the use of Artificial Intelligence-based methods in head and neck cancer diagnosis [28].…”
Section: Head and Neck Cancermentioning
confidence: 99%
“…The oncogenic role of some viruses in different types of tumors has been well established by the International Agency for Research on Cancer (IARC), the following examples being relevant: Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are involved in liver carcinogenesis; Epstein–Barr Virus (EBV) is known to be responsible for Burkitt lymphoma in parallel with some co-factors; high-risk types of Human Papilloma Virus (HPV) are associated with cervical cancer and oropharyngeal cancers [ 8 ]. Recent scientific data support the oncogenic role of some viruses in the carcinogenesis of RCC and urothelial carcinoma (UCa).…”
Section: Introductionmentioning
confidence: 99%