Diagnostischer Wert des S-100-Proteins und der Neuronenspezifischen Enolase als Serummarker zerebraler Störungen nach Allgemeinnarkosen

Abstract

Obviously, increased NSE levels seem to indicate cerebral damage only in more severe cases. S-100 does not seem to be brain-specific in patients undergoing orthopaedic surgery. Therefore, the value of S-100 in the assessment of brain disorders is limited.

S100B in brain damage and neurodegeneration

“…The maximum increase of serum S100B was found between 0 and 24 hours after cardiac surgery (AbdulKhaliq et al, 1999;Ashraf et al, 1999;Blomquist et al, 1997;Gao et al, 1999;Gazzolo et al, 1998;Jönsson et al, 1998;Lindberg et al, 1998;Linstedt et al, 2000;Rasmussen et al, 1999). In two studies an additional peak was detected after 48 hours (Jönsson et al, 1998;Rasmussen et al, 1999).…”

“…Concerning an association between neurocognitive function and S100B, the results have proven inconsistent. Some studies show correlations with cognitive deficits (Basile et al, 2001;Kilminster et al, 1999) while others have not been able to reproduce those findings (Linstedt et al, 2000;Rasmussen et al, 1999Rasmussen et al, , 2000. However, the instruments employed to evaluate Cerebro-vascular disorder S100 increased (Ͼ300 ng/L) in 43 out of 48 patients Kim et al, (1996) N ϭ 29 IRMA Sangtec Acute stroke (ischemic and hemorrhagic) S100B was increased in 11 out of 29 patients; peak in ischemic stroke after 3 days, in hemorrhagic stroke after 1 day Abraha et al, (1997) N ϭ 81 IRMA Sangtec Acute stroke (ischemic and hemorrhagic) S100B increased, correlation with infarct volume and outcome, hemorrhagic strokes with slightly higher S100B levels Bü ttner et al, (1997) N ϭ 26 IRMA Sangtec Acute stroke in the middle cerebral artery territory S100B was increased in 21 out of 26 patients, peak after 2-3 days, correlation with neurological deficit on admission and with infarct volume, but not with functional prognosis Fassbender et al, (1997) N ϭ 24 IRMA Sangtec Ischemic stroke S100B correlated with infarct volume and neurological outcome Missler et al, (1997a) N ϭ 44 Immunofluorometric assay (Missler) Acute ischemic stroke S100B increased with a maximum after 2.5 days; correlation with infarct volume and outcome Martens et al, (1998) N ϭ 64 IRMA Sangtec Acute global cerebral ischemia (cardiac arrest) S100B Ͼ 700 ng/L predicted a negative outcome (not regaining consciousness) with high positive predictive value (95%) and high specificity (96%) Rosen et al, (1998) N ϭ 41 IRMA Sangtec Hypoxic brain damage after cardiac arrest S100B increased, peak on day 1; correlation with anoxia time and degree of coma Wunderlich et al, (1999) N ϭ 58 LIA Sangtec Acute ischemic stroke S100B increased, maximum after 2-3 days; correlation with infarct volume and outcome, non-significant association with neuropsychological impairment 3-7 days after stroke Elting et al, (2000) N ϭ 39 LIA Sangtec Ischemic stroke S100B after stroke (range 80-6730 ng/L) higher than after TIA (range 10-730 ng/ L), peak after 3 days; correlation with neurological outcome in stroke patients Herrmann et al, (2000) N ϭ 32 LIA Sangtec Ischemic stroke in anterior circulation system S100B correlated with infarct volume and neurological outcome Bertsch et al, (2001) N ϭ 24 IRMA Sangtec Ischemic stroke S100B correlated with infarct volume and neurological outcome Böttiger et al, (2001) N ϭ 66 IRMA Sangtec Hypoxic brain damage after cardiac arrest S100B higher in patients with brain damage, peak after 2 hours; predictive value for fatal outcome Godet et al,...…”

“…Derkach et al, (2000) N ϭ 27 Chemiluminescence assay CABG with or without hypothermic CPB S100 increased only after CPB, peak mean 3,200 ng/L. Linstedt et al, (2000) N ϭ 40 LIA Sangtec Hip or knee arthroplasty S100 increased, peak 30 minutes after the operation; no correlation between S100B and cognitive deficits Rasmussen et al, (2000) N ϭ 38 LIA Sangtec Carotid endarterectomy (n ϭ 22), abdominal aortic aneurysm repair (n ϭ 16)…”

Serum concentration of S‐100 protein in assessment of cognitive dysfunction after general anesthesia in different types of surgery

“…High incidences of POCD are described in patients undergoing hip or knee arthroplasty (15–17). Nevertheless, there was no correlation between serum concentration of S‐100 and neuropsychological outcome: both patients with and without POCD showed a significant increase of S‐100 serum concentrations postoperatively (18).…”

The Influence of Bone Cement Implantation in Primary Hip Arthroplasty on S100B Protein Serum Concentration and Patients’ Cognitive Functions as Markers of Brain Damage

“…Conclusions are difficult to draw from these results because there are studies [16][17][18] examining correlations between increased S100B protein serum concentrations and worse results in neuropsychological tests. However, in their study, Linstedt et al did not find correlations between S100B concentration and the results of neuropsychological tests [19].…”