Diagonal ear lobe crease is associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease

Zıyrek, Murat; Şahin, Sinan; Ozdemir, Emrah; Acar, Zeydin; Kahraman, Serkan

doi:10.5543/tkda.2016.37806

Cited by 5 publications

(12 citation statements)

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“…The detailed mechanisms of developing earlobe crease is uncertain, although it is speculated to be derived from loss or degeneration of elastic fibers by diminishing blood supply to the earlobes in a pathological study. Ziyrek et al [21] showed an association between the presence of diagonal earlobe crease and increased carotid intima-media thickness and epicardial adipose tissue thickness that the latter indicator can own strongly predict the severity of coronary artery disease. It also seems that the role of earlobe crease in the prediction of CAD can be augmented by the presence of other CAD risk factors such as hypertension and diabetes [21].…”

Section: Discussionmentioning

confidence: 99%

“…Ziyrek et al [21] showed an association between the presence of diagonal earlobe crease and increased carotid intima-media thickness and epicardial adipose tissue thickness that the latter indicator can own strongly predict the severity of coronary artery disease. It also seems that the role of earlobe crease in the prediction of CAD can be augmented by the presence of other CAD risk factors such as hypertension and diabetes [21]. As shown by Kamal in 2017 [13], the effect of hypertension and diabetes on the presence of diagonal earlobe crease is statistically significant.…”

Section: Discussionmentioning

confidence: 99%

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Value of Transverse Groove on the Earlobe and Hair Growth on the Ear to Predict the Risk for Coronary Artery Disease and Its Severity among Iranian Population, in Tehran City

Arefi

Namazi

Safi

et al. 2020

GMJ

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Background: The use of phenotypic parameters along with other noninvasive diagnostic modality can lead to early diagnosis of coronary artery disease (CAD) and prevent its life-threatening outcome. Recently, the application of head and face components for assessing the risk for CAD much attention has been paid. The present study aimed to assess the relationship between ear characteristics (transverse groove on the earlobe and hair growth on the ear) and the risk for CAD and its severity among Iranian patients. Materials and Methods: In this cross-sectional study, the study population consisted of 105 consecutive patients with suspected CAD undergoing coronary angiography. The severity of CAD was determined by the number of disease vessels as well as the presence of left main lesions assessed by coronary angiography. All patients were examined to evaluate the appearance of ear regarding the presence of transverse groove on the earlobe and hair growth on the ear. Results: Comparing cardiovascular parameters across the groups with and without transverse groove on the earlobe showed a higher rate of CAD as well as the higher number of involved coronary arteries than in the groups without transverse groove on the earlobe. Similarly, the presence of CAD and its higher severity were more revealed in patients with hair growth on the ear as compared to the group without this phenotype. According to multivariable logistic regression analysis and with the presence of baseline parameters, the presence of transverse groove on the earlobe and hair growth on the ear increased the risk for CAD by 2.4 and 4.4 fold, respectively. Conclusion: Along with classic cardiovascular risk factors, the role of growing hair on the ear and transverse groove on the ear to predict high risk for CAD should be considered. [GMJ.2019;8:e1443]

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Value of Transverse Groove on the Earlobe and Hair Growth on the Ear to Predict the Risk for Coronary Artery Disease and Its Severity among Iranian Population, in Tehran City

Arefi

Namazi

Safi

et al. 2020

GMJ

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“…Most of the studies trying to demonstrate an association between ELC and cIMT disclosed an apparent association between both variables [5, 6, 7, 8, 9]. However, the aforementioned studies were flawed by either biased selection of participants, a small sample size, limited assessment of the cIMT to a single artery wall, and different cutoffs used for defining an increased cIMT (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…It is also possible that the ELC might be genetically determined, which might explain its different correlates with atherosclerosis according to race/ethnicity [4]. Information on the association between ELC and the carotid intima-media thickness (cIMT) – a surrogate of extracranial atherosclerosis – is limited [5, 6, 7, 8, 9]. Using the Atahualpa Project cohort, we aimed to assess this association in community-dwelling adults.…”

Section: Introductionmentioning

confidence: 99%

On the association between earlobe crease and the carotid intima-media thickness: A population-based study

Brutto

Mera

Costa

et al. 2019

Heliyon

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The earlobe crease (ELC) has been linked to coronary artery disease, but there is limited information on the association between ELC and extracranial atherosclerosis. Using the Atahualpa Project cohort, we aimed to assess the association between ELC and increased carotid intima-media thickness (cIMT). Atahualpa residents aged ≥40 years underwent visual inspection of both earlobes to evaluate ELC presence, and ultrasound examinations of carotid arteries to calculate the cIMT. The association between both variables was assessed by logistic regression and predictive models, after adjusting for relevant confounders. Mean age of 570 enrolled individuals was 61.5 ± 12.4 years (58% women). ELC was present in 221 (39%) participants. The mean cIMT was 0.85 ± 0.19 mm, with 81 individuals (14%) having an increased cIMT (>1 mm). Univariate logistic regression showed a significant association between ELC presence and increased cIMT (OR: 1.67; 95% C.I.: 1.04–2.69), which disappeared when age (OR: 1.09; 95% C.I.: 0.65–1.85) and other covariables (OR: 1.06; 95% C.I.: 0.62–1.84) were added to the model. Predictive cIMT margins did not differ according to ELC presence or absence, with participants stratified in quartiles of age. This study shows that the effect of the increase in cIMT in subjects with ELC is related to aging.

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“…[1][2][3] This simple clinical sign that can be easily observed and was fi rst described by Frank in routine clinical examination in 1973 ,who reported the signifi cant association of ELC with increased risk for coronary artery disease. [1][2][3][4][5] From that year forward, several studies have evaluated the potential link between ELC and coronary risk factors or coronary artery disease. 1,3,5 However, there is still uncertainty regarding the relevance of ELC to coronary atherosclerosis burden despite the notable number of studies available on this issue.…”

Section: Introductionmentioning

confidence: 99%

Earlobe crease relationship with coronary atherosclerotic burden and pericardial adiposity

Al‐Mosawi¹,

Alam²,

Radhi³

et al. 2022

Cor Vasa

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Vzhledem k omezenému množství údajů stále ještě panuje značná nejistota ohledně významu a korelace mezi záhybem ušního lalůčku (earlobe crease, ELC) a zátěží koronárních tepen aterosklerózou plus adipozitou perikardu. Cíl: Cílem naší studie bylo zhodnotit souvislost mezi ELC a zátěží koronárních tepen aterosklerózou hodnocenou výpočtem kalciového skóre koronárních tepen (coronary artery calcium score, CAC), přítomností plátů a závažností koronárních stenóz i mezi ELC a objemem perikardiálního tuku (pericardial fat volume, PFV) u pacientů s podezřením na ischemickou chorobu srdeční. Metody: Do studie bylo zařazeno 70 pacientů odeslaných na naše oddělení pro klinické podezření na ischemickou chorobu srdeční, u nichž bylo provedeno vyšetření 64řádkovou CT koronarografi í; z uvedeného počtu jich 33 (47 %) mělo ELC. Výsledky: Přítomnost ELC vykazovala po adjustaci na klasické faktory rizika vzniku koronárních příhod statisticky významně nezávislou korelaci se zvýšenou hodnotou CAC (OR [CI] = 3 [2-10]; p < 0,01), významnou koronární stenózou (OR [CI] = 3 [2-8]; p < 0,01) a s přítomností koronárních plátů (OR [CI] = 4 [3,5-9]; p < 0,01). Po adjustaci na klasické faktory rizika vzniku koronárních příhod byla přítomnost ELC (p < 0,01) nezávisle a významně spojena se zvýšenou hodnotou PFV. Závěr: Přítomnost ELC je významně a nezávisle spojena se zátěží aterosklerózy koronárních tepen a zvýšenou adipozitou perikardu.

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Diagonal ear lobe crease is associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease

Abstract: A significant and independent association between the presence of DELC and increased CIMT and EAT thickness was presently determined, for the first time, in subjects free of clinical cardiovascular disease.

Cited by 5 publications

References 0 publications

Value of Transverse Groove on the Earlobe and Hair Growth on the Ear to Predict the Risk for Coronary Artery Disease and Its Severity among Iranian Population, in Tehran City

Value of Transverse Groove on the Earlobe and Hair Growth on the Ear to Predict the Risk for Coronary Artery Disease and Its Severity among Iranian Population, in Tehran City

On the association between earlobe crease and the carotid intima-media thickness: A population-based study

Earlobe crease relationship with coronary atherosclerotic burden and pericardial adiposity

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