Abstract. We characterize diagonals of unbounded self-adjoint operators on a Hilbert space H that have only discrete spectrum, i.e., with empty essential spectrum. Our result extends the Schur-Horn theorem from a finite dimensional setting to an infinite dimensional Hilbert space, analogous to Kadison's theorem for orthogonal projections [17,18], Kaftal and Weiss [21] results for positive compact operators, and Bownik and Jasper [10,11,16] characterization for operators with finite spectrum. Furthermore, we show that if a symmetric unbounded operator E on H has a nondecreasing unbounded diagonal, then any sequence that weakly majorizes this diagonal is also a diagonal of E.