Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: a systematic review

Totty, Joshua; Bua, Nelson; Smith, George E.; Harwood, Amy; Carradice, Daniel; Wallace, Tom; Chetter, Ian

doi:10.12968/jowc.2017.26.3.107

Cited by 60 publications

(62 citation statements)

References 18 publications

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“…It cannot, however, be clearly defined which of these compounds is the actual hapten. To our knowledge, this is the first case of contact sensitization to Cutimed Sorbact reported in the literature …”

Section: Discussionmentioning

confidence: 99%

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Contact dermatitis caused by dialkylcarbamoyl compounds in a medication used for chronic wounds

et al. 2018

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Section: Discussionmentioning

confidence: 99%

“…To our knowledge, this is the first case of contact sensitization to Cutimed Sorbact reported in the literature. 5…”

mentioning

confidence: 99%

Contact dermatitis caused by dialkylcarbamoyl compounds in a medication used for chronic wounds

et al. 2018

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“…This can be applied to dressings to irreversibly bind bacteria, thus removing them from the wound bed . Evidence in various types of surgery suggests that DACC‐coated dressings show promise in the prevention of SSIs . Robust randomised evidence is required to properly investigate the effectiveness of this technology.…”

Section: Introductionmentioning

confidence: 99%

A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride‐coated dressings versus standard care for the primary prevention of surgical site infection

Totty

Hitchman

Cai

et al. 2019

International Wound Journal

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A surgical site infection (SSI) may occur in up to 30% of procedures and results in significant morbidity and mortality. We aimed to assess the feasibility of conducting a randomised controlled trial (RCT) examining the use of dialkylcarbamoylchloride (DACC)-impregnated dressings, which bind bacteria at the wound bed, in the prevention of SSI in primarily closed incisional wounds. This pilot RCT recruited patients undergoing clean or clean-contaminated vascular surgery. Participants were randomised intraoperatively on a 1:1 basis to either a DACC-coated dressing or a control dressing. Outcomes were divided into feasibility and clinical outcomes. The primary clinical outcome was SSI at 30 days (assessed using Centers for Disease Control criteria and Additional treatment, Serous discharge, Erythema, Purulent exudate, Separation of the deep tissues, Isolation of bacteria and duration of inpatient Stay scoring methods). This study recruited 144 patients in 12 months at a median rate of 10 per month. Eligibility was 73% and recruitment 60%. At 30 days, there was a 36.9% relative risk reduction in the DACC-coated arm (16.22% versus 25.71%, odds ratio 0.559, P = 0.161). The number needed to treat was 11 patients. A large-scale RCT is both achievable and desirable given the relative risk reduction shown in this study. Further work is needed to improve the study protocol and involve more centres in a full-scale RCT.

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“…Due to its highly hydrophobic characteristics, microorganism with hydrophobic extracellular surfaces that are commonly found in chronic wounds attach to the DACC coating on the wound dressing and can therefore be removed with dressing change. The results of this analysis provide information for practitioners and can support them in the decision-making process in VLU treatment [12]. …”

Section: Introductionmentioning

confidence: 99%

Budget impact of antimicrobial wound dressings in the treatment of venous leg ulcers in the German outpatient care sector: a budget impact analysis

Gueltzow¹,

Khalilpour²,

Kolbe³

et al. 2018

Journal of Market Access & Health Policy

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Background: Hard-to-heal wounds are associated with high treatment costs and, in Germany, are mostly treated in the outpatient care sector. Wound dressings are the main cost-drivers in venous leg ulcer (VLU) care which prescription is budget-restricted. Objective: To determine to what extent the choice of antimicrobial dressing affects the spending in outpatient care by investigating the budget impact of the bioburden-reducing dressing Cutimed Sorbact. Methods: The budget impact analysis was performed comparing three different scenarios of the intervention mix of antimicrobial dressings. A Markov model was used to estimate the VLU progression during one year. The budget impact was determined by comparing the dressing and medicine resource use and costs of the three scenarios. Results: This analysis confirms the high treatment costs of VLU care. ScenarioA leads to a decreased resource use of antimicrobial dressings and results in 20.86% lower treatment costs after 12 months. The increased use of Cutimed Sorbact has a positive budget impact. Conclusion: This analysis indicates that the treatment of VLU patients may result in an exceedance of the budget per patient that is available to the treating practitioner. The choice of wound dressing, however, may positively affect the prescribers’ budget spending in outpatient care.

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Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: a systematic review

Abstract: Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.

Cited by 60 publications

References 18 publications

Contact dermatitis caused by dialkylcarbamoyl compounds in a medication used for chronic wounds

Contact dermatitis caused by dialkylcarbamoyl compounds in a medication used for chronic wounds

A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride‐coated dressings versus standard care for the primary prevention of surgical site infection

Budget impact of antimicrobial wound dressings in the treatment of venous leg ulcers in the German outpatient care sector: a budget impact analysis

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