Dialkylcarbamoyl chloride-impregnated dressing for the prevention of surgical site infection in women undergoing cesarean section: a pilot study

Stanirowski, Paweł Jan; Kociszewska, Anna; Cendrowski, Krzysztof; Sawicki, Włodzimierz

doi:10.5114/aoms.2015.47654

Cited by 18 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The technique of a transverse skin incision (Pfannenstiel) followed by a transverse uterine incision in its lower segment was used in all women, as described previously [ 10 ]. For subcutaneous tissue and skin incision closure, single monofilament absorbable suture (Monosyn 2/0, B. Braun Melsungen AG, Germany) and subcuticular continuous monofilament non-absorbable suture (Prolene 2-0, Ethicon, Somerville, NJ), were used respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The study plan resembled the one described in the pilot study [ 10 ]. Briefly, the dressing was left in situ for the first 48 h post-operatively in all participants, unless there were reasons for replacement, e.g., wound hemorrhage or detachment of the dressing.…”

Section: Methodsmentioning

confidence: 99%

“…A recently published pilot study revealed a downward trend in SSI rates after CS if dialkylcarbamoyl chloride (DACC) impregnated dressings were used as method of post-operative SSI prevention [ 10 ]. The characteristic feature of the dressing, whose fibers were covered with a hydrophobic derivate of fatty acids, is its solely physical mechanism of action.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Randomized Controlled Trial Evaluating Dialkylcarbamoyl Chloride Impregnated Dressings for the Prevention of Surgical Site Infections in Adult Women Undergoing Cesarean Section

Stanirowski

Bizoń

Cendrowski

et al. 2016

Surgical Infections

Self Cite

View full text Add to dashboard Cite

Background: Surgical site infections (SSI) occur in 1.8%–9.2% of women undergoing cesarean section (CS) and lead to greater morbidity rates and increased treatment costs. The aim of the study was to evaluate the efficacy and cost-effectiveness of dialkylcarbamoyl chloride (DACC) impregnated dressings to prevent SSI in women subject to CS.Methods: Randomized, controlled trial was conducted at the Mazovian Bródno Hospital, a tertiary care center performing approximately 1300 deliveries per year, between June 2014 and April 2015. Patients were randomly allocated to receive either DACC impregnated dressing or standard surgical dressing (SSD) following skin closure. In order to analyze cost-effectiveness of the selected dressings in the group of patients who developed SSI, the costs of ambulatory visits, additional hospitalization, nursing care, and systemic antibiotic therapy were assessed. Independent risk factors for SSI were determined by multivariable logistic regression.Results: Five hundred and forty-three women undergoing elective or emergency CS were enrolled. The SSI rates in the DACC and SSD groups were 1.8% and 5.2%, respectively (p = 0.04). The total cost of SSI prophylaxis and treatment was greater in the control group as compared with the study group (5775 EUR vs. 1065 EUR, respectively). Independent risk factors for SSI included higher pre-pregnancy body mass index (adjusted odds ratio [aOR] = 1.08; [95% confidence interval [CI]: 1.0–1.2]; p < 0.05), smoking in pregnancy (aOR = 5.34; [95% CI: 1.6–15.4]; p < 0.01), and SSD application (aOR = 2.94; [95% CI: 1.1–9.3]; p < 0.05).Conclusion: The study confirmed the efficacy and cost-effectiveness of DACC impregnated dressings in SSI prevention among women undergoing CS.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Randomized Controlled Trial Evaluating Dialkylcarbamoyl Chloride Impregnated Dressings for the Prevention of Surgical Site Infections in Adult Women Undergoing Cesarean Section

Stanirowski

Bizoń

Cendrowski

et al. 2016

Surgical Infections

Self Cite

View full text Add to dashboard Cite

show abstract

“…The microorganisms commonly responsible for surgical‐site infection, or that colonize chronic wounds, generally have hydrophobic extracellular surfaces and therefore adhere irreversibly to the DACC coating. Two groups have recently shown a reduction in infection rates when DACC‐coated dressings were used, and this property could be particularly valuable for wounds prone to infection, such as pilonidal sinus wounds.…”

Section: Introductionmentioning

confidence: 99%

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

et al. 2020

View full text Add to dashboard Cite

Background Disease of the pilonidal sinus is a common condition that affects mainly young adults. Options for management include excision of the sinus tracts, leaving the wound open to heal by secondary intention. The aim of this study was to compare wound healing with dialkylcarbamoyl chloride (DACC)‐coated dressings versus alginate dressings. Methods This multicentre trial randomized consecutive patients undergoing surgery for pilonidal disease to postoperative wound care with either DACC‐coated or alginate dressings. The primary outcome was the proportion of wounds healed after 75 days. Secondary outcomes were the local status of wounds during the healing process, the quality assessment of the dressings by the patient, and the time needed to return to usual activities. Results A total of 246 patients were included: 120 in the DACC‐coated group and 126 in the alginate group. In per‐protocol analysis, there were significantly more patients with completely healed wounds after 75 days in the DACC group than in the alginate group: 78 of 103 (75·7 per cent) versus 58 of 97 (60 per cent) respectively (odds ratio 2·55, 95 per cent c.i. 1·12 to 5·92; P = 0·023). During follow‐up, wounds with alginate dressings had more fibrin than those with DACC‐coated dressings, but the difference was not significant (P = 0·079). There was no difference between the two arms in patients' assessment of the dressings. Conclusion The number of wounds completely healed at 75 days was significantly higher for DACC‐coated compared with alginate dressings. However, the preplanned, clinically significant improvement in healing of 20 per cent was not reached. Registration number: NCT02011802 ( https://clinicaltrials.gov/).

show abstract

“…For instance, bacterial-binding dressings have been shown to reduce SSI following vascular surgery 14,15 and caesarean section. 16,17 In one study, 100 consecutive patients undergoing non-implant vascular surgery at a single academic vascular centre received conventional surgical dressings followed by 100 patients who received bacterial-binding dressings. Wounds were reviewed for signs of infection at five days and 30 days postoperatively.…”

mentioning

confidence: 99%

Cost-effectiveness of a bacterial-binding dressing to prevent surgical site infection following caesarean section

et al. 2019

Self Cite

View full text Add to dashboard Cite

Objective: A randomised controlled trial (RCT) recruited women undergoing caesarean section (CS) in Poland. The aim of the trial was to assess the efficacy of a dialkylcarbamoyl chloride (DACC)-impregnated surgical dressing (bacterial-binding dressings) compared with standard of care (SoC) in preventing surgical site infection (SSI). The aim of the present analysis was to evaluate the cost-effectiveness of the bacterial-binding dressings in the context of the UK National Health Service (NHS). Method: The clinical trial randomised patients to a bacterial-binding dressing (n=272) or a standard surgical dressing (n=271). The study recorded the presence of SSI and associated resource use up to 14 days postoperatively. To generalise results to the NHS, UK unit costs were applied to resource use recorded in the trial. An alternative approach applied a single UK-specific episode cost per SSI. Results: There were 543 women recruited to the trial. SSI rates were 5/272 (1.8%) and 14/271 (5.2%) for bacterial-binding dressings and SoC, respectively (p=0.04). Patients in the bacterial-binding dressing group had six fewer outpatient visits and 33 fewer hospital bed-days. The mean length of SSI-attributable hospitalisation was 2.36 days. Applying UK unit costs at 2017 prices to resource use recorded in the trial, costs of SSI prophylaxis and treatment were £48.97 and £24.69 per patient in the SoC and bacterial-binding dressing groups respectively, a difference of £24.27 (49.6%) per patient. The alternative costing approach produced a cost saving of £119 (57.6%) per patient with the bacterial-binding dressing. Conclusion: Use of bacterial-binding dressings following CS has the potential to reduce the incidence of SSI and costs to the NHS.

show abstract

Dialkylcarbamoyl chloride-impregnated dressing for the prevention of surgical site infection in women undergoing cesarean section: a pilot study

Cited by 18 publications

References 23 publications

Randomized Controlled Trial Evaluating Dialkylcarbamoyl Chloride Impregnated Dressings for the Prevention of Surgical Site Infections in Adult Women Undergoing Cesarean Section

Randomized Controlled Trial Evaluating Dialkylcarbamoyl Chloride Impregnated Dressings for the Prevention of Surgical Site Infections in Adult Women Undergoing Cesarean Section

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

Cost-effectiveness of a bacterial-binding dressing to prevent surgical site infection following caesarean section

Contact Info

Product

Resources

About