Diallyl sulfide alleviates cyclophosphamide-induced nephropathic encephalopathy in rats

Galal, Shereen Mohamed; Mansour, Heba H.; Elkhoely, Abeer

doi:10.1080/15376516.2019.1695991

Cited by 9 publications

(17 citation statements)

References 48 publications

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“…In the study we performed, cyclophosphamide caused a significant increase in kidney index which indicates that the edema of the renal tissue, and similar changes were described by Dobrek et al [11] in a rat model or by Jiang et al [74] in a mice model of chronic CPX administration. In the CPX group, we noticed a significant increase in serum potassium and creatinine levels which was reported by many other authors after CPX injection to rats [10,75,76] or mice [77][78][79] in both acute and chronic models of CPX administration. Mesna alone only partly decreased the potassium level, but carvedilol alone or in combination with mesna completely reversed the CPX-induced alteration in serum potassium.…”

Section: Discussionsupporting

confidence: 84%

“…Additionally, in groups receiving CPX, different levels of the swelling tubules were noticed. Similarly, other authors described swelling of proximal convoluted tubules, inflammatory cells infiltration, tubular and glomeruli atrophy, tubular degeneration, and dilatation in Bowman's capsules [76][77][78][79]83]. In contrast to our study, Dobrek et al [47] did not reveal any significant pathology in the rat kidneys after the same intraperitoneal dose of CPX.…”

Section: Discussioncontrasting

confidence: 56%

“…We cannot exclude that a longer treatment with a low dose of carvedilol is necessary for the full antioxidant effect to be revealed. Interleukin 1β is an important proinflammatory cytokine and its level is increased after CPX administration in serum [75,76], urinary bladder [69,82], kidney [75,83], and many other tissues [84]. Carvedilol is potent in decreasing IL-1β concentration or mRNA expression in the model of brain I/R injury [85], experimental myocardial infarction [63], drug-induced cardiotoxicity [23,57], diabetes [62], or even in the rat model of periodontitis [22].…”

Section: Discussionmentioning

confidence: 99%

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Effect of a Low Dose of Carvedilol on Cyclophosphamide-Induced Urinary Toxicity in Rats—A Comparison with Mesna

et al. 2021

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One of the major side effects of cyclophosphamide (CPX)—an alkylating anticancer drug that is still clinically used—is urotoxicity with hemorrhagic cystitis. The present study was designed to evaluate the ability of carvedilol to protect rats from cyclophosphamide-induced urotoxicity. Rats were injected intraperitoneally (i.p.) with CPX (200 mg/kg) and administered carvedilol (2 mg/kg) intragastrically a day before, at the day and a day after a single i.p. injection of CPX, with or without mesna (40, 80, and 80 mg/kg i.p. 20 min before, 4 h and 8 h after CPX administration, respectively). Pretreatment with carvedilol partly prevented the CPX-induced increase in urinary bladder and kidney index, and completely protects from CPX-evoked alterations in serum potassium and creatinine level, but did not prevent histological alterations in the urinary bladder and hematuria. However, carvedilol administration resulted in significant restoration of kidney glutathione (GSH) level and a decrease in kidney interleukin 1β (IL-1β) and plasma asymmetric dimethylarginine (ADMA) concentrations. Not only did mesna improve kidney function, but it also completely reversed histological abnormalities in bladders and prevented hematuria. In most cases, no significant interaction of carvedilol with mesna was observed, although the effect of both drugs together was better than mesna given alone regarding plasma ADMA level and kidney IL-1β concentration. In conclusion, carvedilol did not counteract the injury caused in the urinary bladders but restored kidney function, presumably via its antioxidant and anti-inflammatory properties.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

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Effect of a Low Dose of Carvedilol on Cyclophosphamide-Induced Urinary Toxicity in Rats—A Comparison with Mesna

et al. 2021

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“…DAS for 4 days before CP resulted in moderate positive immunohistochemical expression of glial fibrillary acidic protein (GFAP) in the brain and renal tissues, similar to CP-treated rats. Due to its ability to improve the aforementioned biochemical markers, DAS provided renal and neuroprotection against CPinduced nephropathic encephalopathy, which was validated by histological and immunohistochemical testing [94]. By stimulating the Nrf2/ARE signaling pathway, DATS, a garlic polysulfide, protects rats from oxidative nephrotoxicity, apoptosis and inflammation caused by arsenic [95].…”

Section: Nephropathic Encephalopathymentioning

confidence: 95%

Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review

Ahmed¹,

Fahim²,

Abdelmohsen³

2022

Journal of advanced Biomedical and Pharmaceutical Sciences

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Medicinal plants provide a variety of secondary metabolites with varied chemical structures and biological activities. Among them, Allium sativum L. (garlic) is one of the most common edible and traditional plant that is used for the prevention and treatment of several diseases. A. sativum belongs to the family Liliaceae and it demonstrated diverse groups of natural compounds (184 compounds), such as organosulfur compounds, amino acids, selenium derivatives, saponins, phenyl propanoids, flavonoids, alkaloids, fatty acids, sterols and others. Therefore, this review focuses on the different classes of secondary metabolites that have been isolated from A. sativum, along with their valued pharmacological and therapeutic effects, e.g., anti-infective (antiprotozoal, antibacterial, antifungal and antiviral activities), antidiabetic, antihyperlipidemic, antihypertensive, heart protective, neuroprotective, hepatoprotective, antioxidant, anticancer, antiobesity, wound and scar healing, antianxiety, antidepressant, immunostimulant and memory enhancing properties. The potential of garlic in the treatment of many diseases such as gastrointestinal disorders, nephropathic encephalopathy and osteoarthritis has been also reported.

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“…Furthermore, treatment with gallic acid restored the enzymic and nonenzymic antioxidants and also attenuated cyclophosphamide-induced nephrotoxicity through free radical scavenging activity, anti-inflammatory, and improvement of antioxidant defense system [ 25 ]. Other compounds/extracts also prevented cyclophosphamide-induced kidney damage, including ozone therapy [ 26 ], hydroalcoholic extract of Capparis spinosa [ 27 ], methanolic extract of Curcuma caesia [ 28 ], Diallyl sulfide [ 29 ], Nigella sativa oil, and thymoquinone [ 30 ] ( Table 1 ). Additionally, currently available drugs also show renoprotective effect ( Table 2 ).…”

Section: Mechanisms and Role Of Antioxidants In Cyclophosphamide-indu...mentioning

confidence: 99%

Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

Ayza

Zewdie

Yigzaw

et al. 2022

International Journal of Nephrology

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Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.

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Diallyl sulfide alleviates cyclophosphamide-induced nephropathic encephalopathy in rats

Cited by 9 publications

References 48 publications

Effect of a Low Dose of Carvedilol on Cyclophosphamide-Induced Urinary Toxicity in Rats—A Comparison with Mesna

Effect of a Low Dose of Carvedilol on Cyclophosphamide-Induced Urinary Toxicity in Rats—A Comparison with Mesna

Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review

Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

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