Diallyl Toxiferine

We have investigated the effects of alcuronium (0.15 mg/kg body weight) on heart rate, stroke volume, cardiac output, mean arterial blood pressure and total peripheral resistance in 22 artificially ventilated patients anaesthetized with 60 per cent nitrous oxide in oxygen, plus either tubocurarine (25-35 mg, according to body weight) and 0.2 per cent methoxyflurane-series I-or phenoperidine (1 mg/15 kg body weight)-series II. End-tidal Pco 3 was maintained constant. The most striking effect was a significant increase of heart rate in the series II patients, accompanied by a significant fall of cardiac output and of stroke volume. There was no significant change of mean arterial pressure in either series of patients; therefore the fall of cardiac output was accompanied by a compensatory increase of total peripheral resistance.

Section: Discussionsupporting

confidence: 90%

Cardiovascular Effects of Alcuronium in Man

Kennedy¹,

Kelman

1970

“…This has been observed in adult patients by Lund and Stovner (1962) and in children by Bush (1965). However, Hunter (1964) observed that diallyinortoxiferine was not adequately reversed with neostigmine. This can be attributed to the degree of neuromuscular block at the time of reversal; Hunter used maintenance doses of 5 mg in some patients.…”

Section: Discussionmentioning

confidence: 92%

A Comparative Study Between Diallylnortoxiferine and Tubocurarine

Baraka

1967

Diallylnortoxiferine and tubocurarine were compared clinically in 493 adult patients undergoing a variety of surgical procedures. Diallylnortoxiferine was found to be approximately twice as potent as tubocurarine. Equipotent doses produced neuromuscular block of the same degree and duration. The incidence of hypotension, its degree and its age distribution are equal. Hypotension occurred in both groups, and its incidence was higher in patients above 40 years, and in patients with an initial blood pressure above 150 mm Hg. Both relaxants are adequately reversed with a mixture of atropine 0.02 mg/kg and neostigmine 0.05 mg/kg, provided an overdose of the relaxant used is avoided.

“…In particular the effects of alcuronium on arterial pressure and pulse rate have been reported to be insignificant during clinical anaesthesia (Hiigin and Kissling, 1961;Canak, 1965;Ahnefeld, Frey and Halmagyi, 1966), whereas tubocurarine may lower the blood pressure, particularly when given in high doses (Thomas, 1957). Comparative studies of alcuronium and tubocurarine are few (Hunter, 1964;Baraka, 1967) and no report is concerned exclusively with the circulatory effects. Hunter (1964) and Baraka (1967) noted that alcuronium and tubocurarine caused hypotension of equal degree.…”

mentioning

confidence: 99%

The Effect of Alcuronium and Tubocurarine on Blood Pressure and Heart Rate: A Clinical Comparison

Tammisto

Welling

1969

The effects of alcuronium (0.15 and 0.3 mg/kg) and tubocurarine (0.3 and 0.6 mg/kg) on arterial pressure and heart rate and rhythm have been compared in forty patients during nitrous oxide, oxygen and pethidine anaesthesia and in twenty patients during nitrous oxide, oxygen and halothane anaesthesia, prior to surgery. When halothane was used only the smaller doses of relaxants were given. Patients were divided into six homologous groups of ten patients. Both relaxants caused a fall in arterial pressure which was more pronounced during halothane anaesthesia. The fall in pressure was equal in degree after both relaxants but the period of maximum lowering was different, being 3-5 minutes after alcuronium and 10-15 minutes after tubocurarine. This difference might be explained by the tubocurarine-induced initial rise in blood pressure which was probably due to pain from venous irritation. Alcuronium had a slight tachycardic effect which was more pronounced during halothane anaesthesia. No e.c.g. changes were seen.