Diallyl Trisulfide Inhibits Growth of NCI-H460 <i>in Vitro </i>and <i>in Vivo</i>, and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice

Jiang, Xiaoyan; Zhu, Xiaosong; Liu, Na; Xu, Hongya; Zhao, Zhongxi; Li, Siying; Li, Sanzhong; Cai, Jingyi; Cao, Ji‐Min

doi:10.7150/ijbs.16828

Cited by 27 publications

(15 citation statements)

References 41 publications

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“…Portions of the suspension (5 × 10 6 cells in 0.1 ml/mouse) were mixed at a 3:1 ratio with Matrigel basement membrane matrix and injected subcutaneously into the mice. Following 2 weeks of growth, tumor tissues were cut into multiple 2 × 2 × 2 mm 3 pieces and implanted using a range trocar subcutaneously (s.c. injection) into the left forepaw armpit of each mouse (Jiang et al, 2017). Treatment with pharmacology was started when the tumors reached an average volume of 100–200 mm 3 .…”

Section: Methodsmentioning

confidence: 99%

Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a Low Rate of Acquired Treatment Resistance

et al. 2019

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Background: Platinum-based drugs prevail as the main treatment of lung cancer; this is caused by their relative effectiveness despite known side effects, such as neurotoxicity. The risk reward of the treatment and side effects is confronted when dosage is considered and when resistance to treatment develops. Development of new compounds that improve effectiveness and safety profiles addresses this ongoing need in clinical practice. Objectives: The novel water-soluble platinum complex, diplatin, was synthesized, and its antitumor potency and toxicology profile were evaluated in murine xenograft tumor models and in lung cancer cell lines. Methods: The effects of diplatin, cisplatin (DDP), and carboplatin (CBP) on the viability of nine lung tumor cell lines and one normal human lung epithelial cell line were evaluated using the MTT assay. Therapeutic index was calculated as LD50/ED50 to identify and compare the ideal therapeutic windows of the above compounds. Diplatin’s antitumor effects were assessed in lung xenograft tumors of nude mice; molecular mechanisms of therapeutic effects were identified. Results: Diplatin had desirable IC50 compared to CBP in a variety of cultured tumor cells, notably lung tumor cells. In the mouse xenograft lung tumor, diplatin led to a substantially improved therapeutic index when compared to the effects of DDP and CBP. Importantly, diplatin inhibited the growth of DDP-resistant lung tumor cells. Diplatin’s mode of action was characterized to be through cell cycle arrest in the G2/M phase and induction of lung tumor apoptosis via ROS/JNK/p53-mediated pathways. Conclusion: Diplatin was observed to have antitumor effects in mice with both greater potency and safety compared with DDP and CBP. These observations indicate that diplatin is promising as a potential treatment in future clinical applications.

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Section: Methodsmentioning

confidence: 99%

Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a Low Rate of Acquired Treatment Resistance

et al. 2019

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“…Activation of p38 in response to NaHS was detected in human monocytes (Sulen et al ., ). Garlic‐derived DATS ameliorates cisplatin‐induced oxidative injury in NCI‐H460 human lung carcinoma cells in a similar manner (Jiang et al ., ).…”

Section: Putative Mechanisms Of Sulfide‐trpa1 Channel Interactionsmentioning

confidence: 97%

Effects of sulfide and polysulfides transmitted by direct or signal transduction‐mediated activation of TRPA1 channels

Pozsgai

Bátai

Pintér

2018

British J Pharmacology

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Hydrogen sulfide (H2S) is a gaseous mediator in various physiological and pathological processes, including neuroimmune modulation, metabolic pathways, cardiovascular system, tumour growth, inflammation and pain. Now the hydrogen polysulfides (H2Sn) have been recognised as signalling molecules modulating ion channels, transcription factors and protein kinases. Transient receptor potential (TRP) cation channels can be activated by mechanical, thermal or chemical triggers. Here, we review the current literature regarding the biological actions of sulfide and polysulfide compounds mediated by TRP channels with special emphasis on the role of TRPA1, best known as ion channels in nociceptors. However, the non‐neuronal TRPA1 channels should also be considered to play regulatory roles. Although sulfide and polysulfide effects in different pathological circumstances and TRPA1‐mediated processes have been investigated intensively, our review attempts to present the first comprehensive overview of the potential crosstalk between TRPA1 channels and sulfide‐activated signalling pathways.Linked ArticlesThis article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.4/issuetoc

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“…It is noteworthy that S-allylcysteine can be detected in the plasma, liver and kidney after oral intake. 135 Previous studies have documented that the bioavailability of S-allylcysteine was 103.0% in mice, 98.2% in rats and 87.2% in dogs. 136 Allicin is supposed to be the chief compound of garlic and Allicin cannot be detected in the blood or urine after the ingestion of raw garlic or pure allicin within 1 to 24 hours after ingestion of 25 g raw garlic.…”

Section: Effect Of Garlic and Its Active Compound Alone And In Combinmentioning

confidence: 99%

Garlic and its Active Compounds: A Novel Strategy to Fight Diseases Through Modulating Biological Activities

Alrumaihi

2020

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Throughout history, many plants and their products have been widely used as medicines for the prevention and treatment of different diseases in many cultures. Garlic (Allium sativum), is commonly used as a spice and traditionally used for its medicinal value since ancient times. Recent studies support the effects of garlic and its extracts in a wide range of applications. Due to the presence of sulfur containing compounds, high trace mineral content and enzymes, garlic has been reported to have implications in disease management and play a role as anti-diabetic, anti-microbial, anti-obesity, anti-oxidant and anti-tumor, dyslipidaemia effect, neuroprotective, cardio-preventive and photo-protection effects. It contains various active compound such as allicin, ajoene, diallyl disulfide and S-allyl-cysteine that modulates various biological cascades and prevent the pathogenesis. This review illustrates the role of garlic and their active ingredients in the health management based on in vivo and in vitro studies.

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Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo, and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice

Cited by 27 publications

References 41 publications

Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a Low Rate of Acquired Treatment Resistance

Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a Low Rate of Acquired Treatment Resistance

Effects of sulfide and polysulfides transmitted by direct or signal transduction‐mediated activation of TRPA1 channels

Garlic and its Active Compounds: A Novel Strategy to Fight Diseases Through Modulating Biological Activities

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