Dialysis Arthropathy: a Clinical, Biochemical, Radiological and Histological Study of 36 Patients

Sethi, D.; Morgan, Toby; Ea, Brown; Cary, Nrb; Erhardt, C. C.; Pazianas, Michael; Maini, R. N.; Woodrow, D F; Gower, P E

doi:10.1093/qjmed/77.1.1061

Cited by 34 publications

(25 citation statements)

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“…Baldrati et al [30] found no connection between the plasmatic level of β-2 microglobulin in patients with dialysis-related amyloidosis and dialysed patents without it. Sethi et al [31] reported that the plasmatic level of β-2 microglobulin was higher in patients with arthropathy than in dialysed patients without it. Serum β-2 microglobulin seems to be an inconstant indicator of dialysis-related arthropathy.…”

Section: Resultsmentioning

confidence: 99%

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Paparella

Barbieri²,

Miscia³

et al. 2014

Anaesthesiol Intensive Ther

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Background: The aim of our study was to evaluate laboratory data behaviour in two dialysis populations, with and without dialysis-related arthropathy and pain. Methods: We produced an elaboration of more than 160,000 items of biochemical data of 25 dialysis-related arthropathy patients with chronic articular pain, and 25 patients asymptomatic for joint pain and arthropathy. The pain visual analogue scale (VAS) was employed for pain intensity determination. Results: The serum level of β-2 microglobulin was similar in the two groups of patients, while ferritin values were significantly higher in symptomatic patients. We excluded the possibility that the ferritin difference between the two groups was due to different iron storage and to an inflammatory profile. Furthermore, the pain VAS mean value was higher in patients who had higher ferritin and pain than in asymptomatic patients. Conclusion:It is important to underline that the higher value of ferritin in patients with chronic pain due to dialysis--related arthropathy could represent a new stimulus for a deeper investigation of this indicator, setting a periodic revelation of pain intensity.

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Section: Resultsmentioning

confidence: 99%

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Paparella

Barbieri²,

Miscia³

et al. 2014

Anaesthesiol Intensive Ther

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“…Imai et al (1986) found shoulder pain in 17.9% of patients who had had dialysis for over ten years. Kurer et al (1991) reported an incidence of 33.7%, Sethi et al (1990) syndrome also suggests that both may be due to amyloidosis (Kachel et al 1983;Charra et al 1984). Okutsu et al (1991) were the first to describe the mechanism of the shoulder pain as impingement between the coracoacromial ligament and the diseased rotator cuff as seen arthroscopically.…”

Section: Discussionmentioning

confidence: 99%

Shoulder Pain in Long-Term Haemodialysis Patients

Konishiike

Hashizume

Nishida

et al. 1996

The Journal of Bone and Joint Surgery. British volume

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We reviewed 166 adult patients on long-term haemodialysis, dividing them into three groups according to the presence and type of shoulder pain. The 24 patients in group A, with spontaneous pain related to a supine posture, had been under haemodialysis for significantly longer than the others, and had a much higher incidence of carpal tunnel syndrome.Open or arthroscopic resection of the coracoacromial ligament in 21 shoulders relieved pain during haemodialysis and night pain, and histological examination showed amyloid deposits and inflammatory-cell infiltration in the subacromial bursa in almost all cases, and in the tenosynovium of the bicipital groove in some.We conclude that one type of shoulder pain experienced by patients on long-term haemodialysis is caused by the subacromial impingement of amyloid deposits. This should be distinguished from other types of shoulder pain, because it can be relieved by resection of the coracoacromial ligament.

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“…Different reports regarding the connection between the level of b2-microglobulin and joint symptoms have been published: Chattopadhyay et al (11) found the b2-microglobulin level was raised in all patients; Nagi et al (12) found no connection between the plasmatic level of b2-microglobulin and detachment of the capsule bone (joint effusion), which is one of the most important parameters of painful shoulder in dialyzed patients; Baldrati et al (13) found no connection between the plasmatic level of b2-microglobulin in patients with dialysis-related amyloidosis and dialyzed patients without it; Sethi et al (14) reported that the plasmatic level of b2-microglobulin was higher in patients with arthropathy than in dialyzed patients without it. Serum b2-microglobulin seems to be an inconstant indicator of dialy-166 Bellini, Paparella: Dialysis arthropathy and the biochemical database sis-related arthropathy.…”

Section: Discussionmentioning

confidence: 99%

Clinical Biochemistry Database Analysis: A Restricted Dialysis Cohort /

Bellini¹,

Paparella²

2013

Journal of Medical Biochemistry

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SummaryBackground: A retrospective study was undertaken to investigate the biochemistry data of a restricted cohort of dialysisrelated arthropathy patients. The aim of our study was to characterize this specific cohort of dialysis patients using a clinical chemistry database analysis. Methods: An elaboration of more than 160,000 items of biochemical data, collected from 2001 to 2011, was made of 50 patients, 25 with dialysis-related arthropathy and 25 patients asymptomatic for arthropathy. A Student's t-test was applied, considering a P-value less than 0.05 as statistically significant. Results: Significant and relevant unexpected biochemical differences were found between the two groups of patients. The serum level of b2-microglobulin was similar, while ferritin values were significantly higher in symptomatic patients. We excluded the possibility that the ferritin difference between the two groups was due to different iron storage and to an inflammatory profile. Conclusions: The correct use of a biochemical database could permit to identify significant values which must be correlated with clinical data, but which could be the first step to a wider research.

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Dialysis Arthropathy: a Clinical, Biochemical, Radiological and Histological Study of 36 Patients

Cited by 34 publications

References 0 publications

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Shoulder Pain in Long-Term Haemodialysis Patients

Clinical Biochemistry Database Analysis: A Restricted Dialysis Cohort /

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