Dialysis-Associated Arthropathy: Secondary Ion Mass Spectrometry Evidence of Aluminum Silicate in &lt;i&gt;β&lt;/i&gt;&lt;sub&gt;2&lt;/sub&gt;-MicroglobuIin Amyloid Synovial Tissue and Articular Cartilage

Chaussidon, M.; Netter, P; Kessler, Matt J.; Membre, H.; Fener, P.; Delons, S; Albarède, Francis

doi:10.1159/000187563

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…Because Al is involved in neurodegenerative processes, this is a clinically relevant observation. As has been shown so far, a chronic exposure to Al causes its accumulation in various tissues [45,46,47,48,49,50,51]. It has been proven that even low doses of aluminum are neurotoxic, induce inflammatory processes, and adversely affect cognitive functions and morphological changes in the central nervous system.…”

Section: Resultsmentioning

confidence: 99%

Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry

et al. 2019

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Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations of chemical elements’ (67) levels in the aqueous humor of patients undergoing cataract surgery. The pilot study included 115 patients, (age 74 ± 7.27, female 64.35%, male 35.65%). The aqueous levels of elements were measured by the use of the inductively coupled plasma optical emission spectrometry (ICP-OES), quality controlled with certified standards. The classification of elements based on their concentration was achieved by hierarchical cluster analysis. This is the first screening study that quantifies over 60 elements which are present in the fluid from the anterior chamber of the eye of cataract patients. The obtained results can be suitable for understanding and identifying the causes that may play a role in the initiation and progression of lens opacity.

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Section: Resultsmentioning

confidence: 99%

Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry

et al. 2019

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“…As noted previously, chronic Al exposure can cause the accumulation of AβP, impair spatial learning memory and induce conformational changes to proteins related to neurodegeneration. These include tau, PHF-tau, synuclein, amylin, ABri, microglobulin, and APP [36,37,38,39,40,41]. A recent study reported brain Al levels of subjects suffering from Alzheimer’s disease and multiple sclerosis, the content of which is in excess of 10 and 50 mg/kg, respectively [11].…”

Section: Discussionmentioning

confidence: 99%

“…The daily intake of Al is about 20mg, and silicon absorption has been evaluated at 20–50 mg. Water and other drinks can provide 19% of daily intake [36].…”

Section: Discussionmentioning

confidence: 99%

Increased Aluminum Content in Certain Brain Structures is Correlated with Higher Silicon Concentration in Alcoholic Use Disorder

et al. 2019

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Introduction: Alcohol overuse may be related to increased aluminum (Al) exposure, the brain accumulation of which contributes to dementia. However, some reports indicate that silicon (Si) may have a protective role over Al-induced toxicity. Still, no study has ever explored the brain content of Al and Si in alcoholic use disorder (AUD). Materials and methods: To fill this gap, the present study employed inductively coupled plasma optical emission spectrometry to investigate levels of Al and Si in 10 brain regions and in the liver of AUD patients (n = 31) and control (n = 32) post-mortem. Results: Al content was detected only in AUD patients at mean ± SD total brain content of 1.59 ± 1.19 mg/kg, with the highest levels in the thalamus (4.05 ± 12.7 mg/kg, FTH), inferior longitudinal fasciculus (3.48 ± 9.67 mg/kg, ILF), insula (2.41 ± 4.10 mg/kg) and superior longitudinal fasciculus (1.08 ± 2.30 mg/kg). Si content displayed no difference between AUD and control, except for FTH. Positive inter-region correlations between the content of both elements were identified in the cingulate cortex, hippocampus, and ILF. Conclusions: The findings of this study suggest that AUD patients may potentially be prone to Al-induced neurodegeneration in their brain—although this hypothesis requires further exploration.

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“…Al has also been reported to bind and cause conformational changes in other AD-related proteins, including APP [138], tau protein [32, 57], and PHF-tau protein [139] and in proteins related to other neurodegenerative diseases such as α -synuclein (Parkinson's disease (PD) and dementia with Lewy bodies; DLB) [140, 141], amylin (diabetes mellitus) [142], ABri (familial British dementia) [143], and ataxin 3 (spinocerebellar ataxia type 3) [144], β 2 -microglobulin (dialysis-related arthropathy) [145] (Table 2). …”

Section: Link Between Al and Admentioning

confidence: 99%

Link between Aluminum and the Pathogenesis of Alzheimer′s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

Kawahara

Kato-Negishi

2011

International Journal of Alzheimer's Disease

326

263

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Whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans. The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer's disease (AD) has been suggested. In particular, the link between aluminum and Alzheimer's disease has been the subject of scientific debate for several decades. However, the complex characteristics of aluminum bioavailability make it difficult to evaluate its toxicity and therefore, the relationship remains to be established. Mounting evidence has suggested that significance of oligomerization of β-amyloid protein and neurotoxicity in the molecular mechanism of AD pathogenesis. Aluminum may play crucial roles as a cross-linker in β-amyloid oligomerization. Here, we review the detailed characteristics of aluminum neurotoxicity based on our own studies and the recent literatures. Our aim is to revisit the link between aluminum and AD and to integrate aluminum and amyloid cascade hypotheses in the context of β-amyloid oligomerization and the interactions with other metals.

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Dialysis-Associated Arthropathy: Secondary Ion Mass Spectrometry Evidence of Aluminum Silicate in <i>β</i><sub>2</sub>-MicroglobuIin Amyloid Synovial Tissue and Articular Cartilage

Cited by 10 publications

References 12 publications

Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry

Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry

Increased Aluminum Content in Certain Brain Structures is Correlated with Higher Silicon Concentration in Alcoholic Use Disorder

Link between Aluminum and the Pathogenesis of Alzheimer′s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

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