1984
DOI: 10.2190/c36r-6wgp-lcyu-9vrg
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Dialysis Encephalopathy: A Review

Abstract: Dialysis encephalopathy (DE) is a distinct neuropsychiatric syndrome typically occurring in patients undergoing longterm hemodialysis. It is characterized by electroencephalographic abnormalities in association with disturbances of speech, cognition, movement, affect, or behavior. Previously thought to be relentlessly progressive, recent evidence linking the illness to aluminum overload has led to advances in prevention and treatment. Early diagnosis aids in the reversal or amelioration of the syndrome and can… Show more

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Cited by 32 publications
(11 citation statements)
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“…The mean age of those affected in a large series was 50 years, with an age range of 21 to 68 42. Mean onset of symptoms after haemodialysis had commenced was 35 months in the same series (range 0.5–112 months).…”
Section: The Effects Of Uraemia On the Nervous Systemmentioning
confidence: 82%
“…The mean age of those affected in a large series was 50 years, with an age range of 21 to 68 42. Mean onset of symptoms after haemodialysis had commenced was 35 months in the same series (range 0.5–112 months).…”
Section: The Effects Of Uraemia On the Nervous Systemmentioning
confidence: 82%
“…An 11-fold increase in the concentration of aluminium was detected in the cerebral cortex of patients with dialysis dementia, compared to a threefold increase in patients undergoing haemodialysis without evidence of dementia. 108 Dialysis dementia is now considered a rare adverse effect of dialysis, with a current estimated prevalence of 0.6-1.0% in dialysis patients. 82 During the peak of prevalence, dialysis dementia was more common among the elderly, women, and those of black ethnicity, and less common among patients receiving peritoneal dialysis and in transplant recipients.…”
Section: Dialysis Dementiamentioning
confidence: 99%
“…Die DE tritt häufiger bei Männern und im Allgemeinen innerhalb von drei Jahren nach Dialysebeginn auf. In einer gröûe-ren Serie betrug das mittlere Alter bei Symptombeginn 50 Jahre [44]. Sie zeigt einen progressiven Verlauf und ist innerhalb von 6 ± 9 Monaten tödlich, wenn sie nicht adäquat und rechtzeitig behandelt wird.…”
Section: Dialyseenzephalopathie (De)unclassified
“…Erste klinische Symptome sind in 95 % der Fälle progressive Sprech-und Sprachstörungen bis hin zur globalen Aphasie, häufig beginnend mit einer stotternden, zögernden dysprosodischen Sprache. Weitere Symptome sind Dysgraphie, Angst mit Depression, Lethargie sowie andere Verhaltensauffälligkeiten [44]. Myoklonus, Asterixis, Ataxie, Dyspraxie, andere Bewegungsstörungen und Gangstörungen sind mit 80 % ebenfalls häufig vertreten, fokale und generalisierte Anfälle treten in bis zu 60 % der Patienten auf [17].…”
Section: Dialyseenzephalopathie (De)unclassified