Dialysis Survival after Graft Loss

Moist, Louise

doi:10.2215/cjn.00660111

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…For example, in the UK 65% of haemodialysis patients commenced dialysis in 2005 using a central venous catheter although by 12 months this had fallen to 30% [52]. In Canada between 2001 and 2004 the prevalence of catheter use in the haemodialysis population was 52% [53]. Table 7).…”

Section: We Recommend Edta Plasma Samples For Pth Measurement Should mentioning

confidence: 99%

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Hanon

Sturgeon

Lamb

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Parathyroid hormone (PTH) is relatively unstable: optimisation of pre-analytical conditions, including specimen type, sampling time and storage conditions, is essential. We have undertaken a systematic review of these pre-analytical conditions. An electronic search of the PubMed, Embase, Cochrane, Centre for Research and Dissemination and Bandolier databases was undertaken. Of 5511 papers identified, 96 underwent full text review, of which 83 were finally included. At room temperature PTH was stable in ethylenediaminetetraacetic acid (EDTA) preserved whole blood for at least 24 h and in EDTA plasma for at least 48 h after venepuncture. Losses were observed in clotted blood samples after 3 h and in serum after 2 h. At 4°C PTH was more stable in EDTA plasma (at least 72 h) than serum (at least 24 h). Central venous PTH concentrations were higher than peripheral venous concentrations. In the northern hemisphere, PTH concentrations were higher in winter than summer. PTH has a circadian rhythm characterised by a nocturnal acrophase and mid-morning nadir. Data related to frozen storage of PTH (−20°C and −80°C) were limited and contradictory. We recommend that blood samples for PTH measurement should be taken into tubes containing EDTA, ideally between 10:00 and 16:00, and plasma separated within 24 h of venepuncture. Plasma samples should be stored at 4°C and analysed within 72 h of venepuncture. Particular regard must be paid to the venepuncture site when interpreting PTH concentration. Further research is required to clarify the suitability of freezing samples prior to PTH measurement.

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Section: We Recommend Edta Plasma Samples For Pth Measurement Should mentioning

confidence: 99%

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Hanon

Sturgeon

Lamb

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Current data shows that graft attrition in the first 12 months after transplantation surgery has dropped markedly in the last two decades, while graft survival in later time periods has improved only modestly [2]. Thus, the need for dialysis after graft loss (DAGL) is among the top five reasons for initiation of dialysis [3], making this an important topic in clinical nephrology. Before examining management of immunologic risks in DAGL patients and the risks and benefits of allograft nephrectomy, we will explore the increased mortality and clinical risks experienced by DAGL patients and address the optimal dialytic modality in these patients.…”

Section: Introductionmentioning

confidence: 99%

Care of the Patient after Renal Allograft Failure: Managing the Present and Planning for the Future

Fuquay

Teitelbaum²

2012

Am J Nephrol

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The number of patients with end-stage renal disease undergoing kidney transplantation – both cadaveric and living-donor – continues to rise. With long-term graft survival relatively fixed, this trend means that increasing numbers of patients are returning to dialysis after graft loss. Most will never be retransplanted, which introduces a host of clinical questions regarding optimal management of this unique patient population. In this paper, we explore data that informs astute care of the patient requiring dialysis after graft loss. We address new data about the increased clinical risk and the optimal dialysis modality in renal allograft loss, explore new approaches to immunosuppression and transfusion management, and examine the risks and benefits of allograft nephrectomy and timing thereof. While there are no randomized clinical trials in this field, rapidly evolving data will aid the clinician whose practice includes patients who have been transplanted and are returning to dialysis.

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Controversies and current status of pre-emptive nephrectomy for asymptomatic failed renal allograft in the late post-transplant period

Javali

Srivastava

2014

Indian Journal of Transplantation

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Dialysis Survival after Graft Loss

Cited by 4 publications

References 12 publications

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Care of the Patient after Renal Allograft Failure: Managing the Present and Planning for the Future

Controversies and current status of pre-emptive nephrectomy for asymptomatic failed renal allograft in the late post-transplant period

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